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Long-term follow up of patients with Zollinger-Ellison syndrome (ZES).
Acta Chir Scand. 1989 Aug; 155(8):383-8.AC

Abstract

We have followed 14 patients with the Zollinger-Ellison syndrome for a median period of 9 years. All patients have suffered from peptic ulcer disease and six of the 14 have had complications such as bleeding or perforated ulcer. Almost half the patients have had diarrhoea as a dominant symptom and 4 patients suffered from multiple endocrine neoplasia. Before 1978, the year when the H2-receptor antagonists were introduced, the majority of the patients were operated with total gastrectomy. After that year there has been no need for gastrectomies, but all but two patients have undergone an explorative laparotomy. We have been able to localize the gastrinoma in 9 of 12 operated patients; in 7 cases it was localized within the gastrinoma triangle. Three of the patients are considered to have been cured after surgery. Eight patients have needed adjuvant acid-reducing medical therapy. Five of these have been failures to high doses of H2-receptor antagonists and have been successfully treated with omeprazole. Five patients have died during the follow-up period and death in two of these cases was related to tumor progression.

Authors+Show Affiliations

Department of Surgery, Sahlgren's Hospital, Göteborg, Sweden.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2574521

Citation

Lind, T, and L Olbe. "Long-term Follow Up of Patients With Zollinger-Ellison Syndrome (ZES)." Acta Chirurgica Scandinavica, vol. 155, no. 8, 1989, pp. 383-8.
Lind T, Olbe L. Long-term follow up of patients with Zollinger-Ellison syndrome (ZES). Acta Chir Scand. 1989;155(8):383-8.
Lind, T., & Olbe, L. (1989). Long-term follow up of patients with Zollinger-Ellison syndrome (ZES). Acta Chirurgica Scandinavica, 155(8), 383-8.
Lind T, Olbe L. Long-term Follow Up of Patients With Zollinger-Ellison Syndrome (ZES). Acta Chir Scand. 1989;155(8):383-8. PubMed PMID: 2574521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term follow up of patients with Zollinger-Ellison syndrome (ZES). AU - Lind,T, AU - Olbe,L, PY - 1989/8/1/pubmed PY - 1989/8/1/medline PY - 1989/8/1/entrez SP - 383 EP - 8 JF - Acta chirurgica Scandinavica JO - Acta Chir Scand VL - 155 IS - 8 N2 - We have followed 14 patients with the Zollinger-Ellison syndrome for a median period of 9 years. All patients have suffered from peptic ulcer disease and six of the 14 have had complications such as bleeding or perforated ulcer. Almost half the patients have had diarrhoea as a dominant symptom and 4 patients suffered from multiple endocrine neoplasia. Before 1978, the year when the H2-receptor antagonists were introduced, the majority of the patients were operated with total gastrectomy. After that year there has been no need for gastrectomies, but all but two patients have undergone an explorative laparotomy. We have been able to localize the gastrinoma in 9 of 12 operated patients; in 7 cases it was localized within the gastrinoma triangle. Three of the patients are considered to have been cured after surgery. Eight patients have needed adjuvant acid-reducing medical therapy. Five of these have been failures to high doses of H2-receptor antagonists and have been successfully treated with omeprazole. Five patients have died during the follow-up period and death in two of these cases was related to tumor progression. SN - 0001-5482 UR - https://www.unboundmedicine.com/medline/citation/2574521/Long_term_follow_up_of_patients_with_Zollinger_Ellison_syndrome__ZES__ L2 - http://www.diseaseinfosearch.org/result/7600 DB - PRIME DP - Unbound Medicine ER -