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Anti-inflammatory and cytoprotective properties of hydrogen sulfide.
Methods Enzymol. 2015; 555:169-93.ME

Abstract

Hydrogen sulfide is an endogenous gaseous mediator that plays important roles in many physiological processes in microbes, plants, and animals. This chapter focuses on the important roles of hydrogen sulfide in protecting tissues against injury, promoting the repair of damage, and downregulating the inflammatory responses. The chapter focuses largely, but not exclusively, on these roles of hydrogen sulfide in the gastrointestinal tract. Hydrogen sulfide is produced throughout the gastrointestinal tract, and it contributes to maintenance of mucosal integrity. Suppression of hydrogen sulfide synthesis renders the tissue more susceptible to injury and it impairs repair. In contrast, administration of hydrogen sulfide donors can increase resistance to injury and accelerate repair. Hydrogen sulfide synthesis is rapidly and dramatically enhanced in the gastrointestinal tract after injury is induced. These increases occur specifically at the site of tissue injury. Hydrogen sulfide also plays an important role in promoting resolution of inflammation, and restoration of normal tissue function. In recent years, these beneficial actions of hydrogen sulfide have provided the basis for development of novel hydrogen sulfide-releasing drugs. Nonsteroidal anti-inflammatory drugs that release small amounts of hydrogen sulfide are among the most advanced of the hydrogen sulfide-based drugs. Unlike the parent drugs, these modified drugs do not cause injury in the gastrointestinal tract, and do not interfere with healing of preexisting damage. Because of the increased safety profile of these drugs, they can be used in circumstances in which the toxicity of the parent drug would normally limit their use, such as in chemoprevention of cancer.

Authors+Show Affiliations

Near East University, Nicosia, Northern Cyprus, Turkey.Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada. Electronic address: altapharm@hotmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25747480

Citation

Gemici, Burcu, and John L. Wallace. "Anti-inflammatory and Cytoprotective Properties of Hydrogen Sulfide." Methods in Enzymology, vol. 555, 2015, pp. 169-93.
Gemici B, Wallace JL. Anti-inflammatory and cytoprotective properties of hydrogen sulfide. Meth Enzymol. 2015;555:169-93.
Gemici, B., & Wallace, J. L. (2015). Anti-inflammatory and cytoprotective properties of hydrogen sulfide. Methods in Enzymology, 555, 169-93. https://doi.org/10.1016/bs.mie.2014.11.034
Gemici B, Wallace JL. Anti-inflammatory and Cytoprotective Properties of Hydrogen Sulfide. Meth Enzymol. 2015;555:169-93. PubMed PMID: 25747480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and cytoprotective properties of hydrogen sulfide. AU - Gemici,Burcu, AU - Wallace,John L, Y1 - 2015/01/08/ PY - 2015/3/10/entrez PY - 2015/3/10/pubmed PY - 2015/12/15/medline KW - Antioxidant KW - Colitis KW - Gastrointestinal KW - Healing KW - Inflammation KW - Leukocyte KW - Ulcer KW - Vascular SP - 169 EP - 93 JF - Methods in enzymology JO - Meth. Enzymol. VL - 555 N2 - Hydrogen sulfide is an endogenous gaseous mediator that plays important roles in many physiological processes in microbes, plants, and animals. This chapter focuses on the important roles of hydrogen sulfide in protecting tissues against injury, promoting the repair of damage, and downregulating the inflammatory responses. The chapter focuses largely, but not exclusively, on these roles of hydrogen sulfide in the gastrointestinal tract. Hydrogen sulfide is produced throughout the gastrointestinal tract, and it contributes to maintenance of mucosal integrity. Suppression of hydrogen sulfide synthesis renders the tissue more susceptible to injury and it impairs repair. In contrast, administration of hydrogen sulfide donors can increase resistance to injury and accelerate repair. Hydrogen sulfide synthesis is rapidly and dramatically enhanced in the gastrointestinal tract after injury is induced. These increases occur specifically at the site of tissue injury. Hydrogen sulfide also plays an important role in promoting resolution of inflammation, and restoration of normal tissue function. In recent years, these beneficial actions of hydrogen sulfide have provided the basis for development of novel hydrogen sulfide-releasing drugs. Nonsteroidal anti-inflammatory drugs that release small amounts of hydrogen sulfide are among the most advanced of the hydrogen sulfide-based drugs. Unlike the parent drugs, these modified drugs do not cause injury in the gastrointestinal tract, and do not interfere with healing of preexisting damage. Because of the increased safety profile of these drugs, they can be used in circumstances in which the toxicity of the parent drug would normally limit their use, such as in chemoprevention of cancer. SN - 1557-7988 UR - https://www.unboundmedicine.com/medline/citation/25747480/Anti_inflammatory_and_cytoprotective_properties_of_hydrogen_sulfide_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0076-6879(14)00099-8 DB - PRIME DP - Unbound Medicine ER -