Tags

Type your tag names separated by a space and hit enter

Type 1 diabetes and gut microbiota: Friend or foe?
Pharmacol Res 2015; 98:9-15PR

Abstract

Type 1 diabetes is a T cell-mediated autoimmune disease. Environmental factors play an important role in the initiation of the disease in genetically predisposed individuals. With the improved control of infectious disease, the incidence of autoimmune diseases, particularly type 1 diabetes, has dramatically increased in developed countries. Increasing evidence suggests that gut microbiota are involved in the pathogenesis of type 1 diabetes. Here we focus on recent advances in this field and provide a rationale for novel therapeutic strategies targeting gut microbiota for the prevention of type 1 diabetes.

Authors+Show Affiliations

Section of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff, UK.Section of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA. Electronic address: li.wen@yale.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25747961

Citation

Hu, Changyun, et al. "Type 1 Diabetes and Gut Microbiota: Friend or Foe?" Pharmacological Research, vol. 98, 2015, pp. 9-15.
Hu C, Wong FS, Wen L. Type 1 diabetes and gut microbiota: Friend or foe? Pharmacol Res. 2015;98:9-15.
Hu, C., Wong, F. S., & Wen, L. (2015). Type 1 diabetes and gut microbiota: Friend or foe? Pharmacological Research, 98, pp. 9-15. doi:10.1016/j.phrs.2015.02.006.
Hu C, Wong FS, Wen L. Type 1 Diabetes and Gut Microbiota: Friend or Foe. Pharmacol Res. 2015;98:9-15. PubMed PMID: 25747961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Type 1 diabetes and gut microbiota: Friend or foe? AU - Hu,Changyun, AU - Wong,F Susan, AU - Wen,Li, Y1 - 2015/03/05/ PY - 2015/01/14/received PY - 2015/02/25/revised PY - 2015/02/25/accepted PY - 2015/3/10/entrez PY - 2015/3/10/pubmed PY - 2016/3/8/medline KW - Autoimmunity KW - Gut microbiota KW - NOD mice KW - Type 1 diabetes SP - 9 EP - 15 JF - Pharmacological research JO - Pharmacol. Res. VL - 98 N2 - Type 1 diabetes is a T cell-mediated autoimmune disease. Environmental factors play an important role in the initiation of the disease in genetically predisposed individuals. With the improved control of infectious disease, the incidence of autoimmune diseases, particularly type 1 diabetes, has dramatically increased in developed countries. Increasing evidence suggests that gut microbiota are involved in the pathogenesis of type 1 diabetes. Here we focus on recent advances in this field and provide a rationale for novel therapeutic strategies targeting gut microbiota for the prevention of type 1 diabetes. SN - 1096-1186 UR - https://www.unboundmedicine.com/medline/citation/25747961/Type_1_diabetes_and_gut_microbiota:_Friend_or_foe L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-6618(15)00029-8 DB - PRIME DP - Unbound Medicine ER -