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Exploring strategies to operationalize cognitive reserve: A systematic review of reviews.
J Clin Exp Neuropsychol 2015; 37(3):253-64JC

Abstract

INTRODUCTION

The cognitive reserve hypothesis suggests that across the lifespan, higher education, regular participation in social or mentally stimulating activities, and complexity of occupation increase an individual's resistance to dementia. However, there is currently no consensus regarding how to assess or measure cognitive reserve.

METHOD

We performed a systematic review of reviews focused on the concept of cognitive reserve to examine key elements of the definition and highlight limitations. We searched Embase.com, MEDLINE (OvidSP), the Cochrane Library, Web of Science, Scopus, Google Scholar, and PubMed.

RESULTS

Five systematic reviews were identified. These incorporated findings from cohort, cross-sectional, and case-control studies, and the outcomes examined included Alzheimer's disease, vascular dementia, nonspecified dementia, all dementias, and cognitive decline or cognitive impairment. Education, occupation, and leisure or mentally stimulating activities were suggested to supply cognitive reserve and offer a protective effect against the risk of dementia. Premorbid IQ and socioeconomic status have not been investigated as thoroughly and showed inconsistent results. Two of the reviews showed that when combining different indicators in the analyses/definition, including education, occupation, mentally stimulating activities, and premorbid IQ, cognitive reserve had a protective effect against cognitive decline. However, other indicators may also supply the reserve, including dietary habits and genetic indicators, but research is lacking with regard to creating a full cognitive reserve model.

CONCLUSIONS

This review highlights the lack of consensus regarding a definition of cognitive reserve. Further research is required to clarify how the indicators already identified may provide cognitive reserve and offer a protective effect against dementia. Agreement on the indicators that constitute the cognitive reserve model is needed before testing possible interventions that may increase the reserve supply and improve cognition.

Authors+Show Affiliations

a Institute for Health and Society, Newcastle University , Newcastle , UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

25748936

Citation

Harrison, Stephanie L., et al. "Exploring Strategies to Operationalize Cognitive Reserve: a Systematic Review of Reviews." Journal of Clinical and Experimental Neuropsychology, vol. 37, no. 3, 2015, pp. 253-64.
Harrison SL, Sajjad A, Bramer WM, et al. Exploring strategies to operationalize cognitive reserve: A systematic review of reviews. J Clin Exp Neuropsychol. 2015;37(3):253-64.
Harrison, S. L., Sajjad, A., Bramer, W. M., Ikram, M. A., Tiemeier, H., & Stephan, B. C. (2015). Exploring strategies to operationalize cognitive reserve: A systematic review of reviews. Journal of Clinical and Experimental Neuropsychology, 37(3), pp. 253-64. doi:10.1080/13803395.2014.1002759.
Harrison SL, et al. Exploring Strategies to Operationalize Cognitive Reserve: a Systematic Review of Reviews. J Clin Exp Neuropsychol. 2015;37(3):253-64. PubMed PMID: 25748936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exploring strategies to operationalize cognitive reserve: A systematic review of reviews. AU - Harrison,Stephanie L, AU - Sajjad,Ayesha, AU - Bramer,Wichor M, AU - Ikram,M Arfan, AU - Tiemeier,Henning, AU - Stephan,Blossom C M, Y1 - 2015/03/09/ PY - 2015/3/10/entrez PY - 2015/3/10/pubmed PY - 2016/2/26/medline KW - Alzheimer’s disease KW - Brain reserve KW - Cognitive reserve KW - Dementia KW - Education SP - 253 EP - 64 JF - Journal of clinical and experimental neuropsychology JO - J Clin Exp Neuropsychol VL - 37 IS - 3 N2 - INTRODUCTION: The cognitive reserve hypothesis suggests that across the lifespan, higher education, regular participation in social or mentally stimulating activities, and complexity of occupation increase an individual's resistance to dementia. However, there is currently no consensus regarding how to assess or measure cognitive reserve. METHOD: We performed a systematic review of reviews focused on the concept of cognitive reserve to examine key elements of the definition and highlight limitations. We searched Embase.com, MEDLINE (OvidSP), the Cochrane Library, Web of Science, Scopus, Google Scholar, and PubMed. RESULTS: Five systematic reviews were identified. These incorporated findings from cohort, cross-sectional, and case-control studies, and the outcomes examined included Alzheimer's disease, vascular dementia, nonspecified dementia, all dementias, and cognitive decline or cognitive impairment. Education, occupation, and leisure or mentally stimulating activities were suggested to supply cognitive reserve and offer a protective effect against the risk of dementia. Premorbid IQ and socioeconomic status have not been investigated as thoroughly and showed inconsistent results. Two of the reviews showed that when combining different indicators in the analyses/definition, including education, occupation, mentally stimulating activities, and premorbid IQ, cognitive reserve had a protective effect against cognitive decline. However, other indicators may also supply the reserve, including dietary habits and genetic indicators, but research is lacking with regard to creating a full cognitive reserve model. CONCLUSIONS: This review highlights the lack of consensus regarding a definition of cognitive reserve. Further research is required to clarify how the indicators already identified may provide cognitive reserve and offer a protective effect against dementia. Agreement on the indicators that constitute the cognitive reserve model is needed before testing possible interventions that may increase the reserve supply and improve cognition. SN - 1744-411X UR - https://www.unboundmedicine.com/medline/citation/25748936/Exploring_strategies_to_operationalize_cognitive_reserve:_A_systematic_review_of_reviews_ L2 - http://www.tandfonline.com/doi/full/10.1080/13803395.2014.1002759 DB - PRIME DP - Unbound Medicine ER -