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Cysteamine normalizes cerebral somatostatin level and binding in pentylenetetrazol-kindled rats.
Life Sci. 1989; 45(25):2451-8.LS

Abstract

Rats were kindled by intraperitoneal injection of pentylenetetrazol (PTZ) (30 mg/Kg) every 48 h. Once kindled, some of the animals received a single injection of cysteamine (200 mg/Kg). Somatostatin-like immunoreactivity (SLI) and 125 I-Tyr11-somatostatin binding were measured in the frontoparietal cortex and hippocampus of the two experimental groups and the control rats. After PTZ kindling the following was observed: 1) SLI content was increased in the two areas; 2) Somatostatin receptor affinity decreased in the frontoparietal cortex and was unaltered in the hippocampus; 3) The number of somatostatin receptors decreased in the hippocampus and was unaltered in the frontoparietal cortex. Cysteamine, an agent which depletes brain somatostatin and suppresses kindled seizures in PTZ-treated rats, reversed the altered SLI levels and binding in these rats.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Alcalá de Henares, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2575202

Citation

Perez-Oso, E, et al. "Cysteamine Normalizes Cerebral Somatostatin Level and Binding in Pentylenetetrazol-kindled Rats." Life Sciences, vol. 45, no. 25, 1989, pp. 2451-8.
Perez-Oso E, Lopez-Ruiz MP, Gonzalez-Guijarro L, et al. Cysteamine normalizes cerebral somatostatin level and binding in pentylenetetrazol-kindled rats. Life Sci. 1989;45(25):2451-8.
Perez-Oso, E., Lopez-Ruiz, M. P., Gonzalez-Guijarro, L., & Arilla, E. (1989). Cysteamine normalizes cerebral somatostatin level and binding in pentylenetetrazol-kindled rats. Life Sciences, 45(25), 2451-8.
Perez-Oso E, et al. Cysteamine Normalizes Cerebral Somatostatin Level and Binding in Pentylenetetrazol-kindled Rats. Life Sci. 1989;45(25):2451-8. PubMed PMID: 2575202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cysteamine normalizes cerebral somatostatin level and binding in pentylenetetrazol-kindled rats. AU - Perez-Oso,E, AU - Lopez-Ruiz,M P, AU - Gonzalez-Guijarro,L, AU - Arilla,E, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 2451 EP - 8 JF - Life sciences JO - Life Sci VL - 45 IS - 25 N2 - Rats were kindled by intraperitoneal injection of pentylenetetrazol (PTZ) (30 mg/Kg) every 48 h. Once kindled, some of the animals received a single injection of cysteamine (200 mg/Kg). Somatostatin-like immunoreactivity (SLI) and 125 I-Tyr11-somatostatin binding were measured in the frontoparietal cortex and hippocampus of the two experimental groups and the control rats. After PTZ kindling the following was observed: 1) SLI content was increased in the two areas; 2) Somatostatin receptor affinity decreased in the frontoparietal cortex and was unaltered in the hippocampus; 3) The number of somatostatin receptors decreased in the hippocampus and was unaltered in the frontoparietal cortex. Cysteamine, an agent which depletes brain somatostatin and suppresses kindled seizures in PTZ-treated rats, reversed the altered SLI levels and binding in these rats. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/2575202/Cysteamine_normalizes_cerebral_somatostatin_level_and_binding_in_pentylenetetrazol_kindled_rats_ DB - PRIME DP - Unbound Medicine ER -