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An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases.
J Physiol Biochem 2015; 71(2):341-9JP

Abstract

Inflammation is involved in the pathophysiology of many chronic diseases, such as rheumatoid arthritis and neurodegenerative diseases. Several studies have evidenced important anti-inflammatory and immunomodulatory properties of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs). This review illustrates current knowledge about the efficacy of n-3 LC-PUFAs (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), particularly) in preventing and/or treating several chronic inflammatory conditions (inflammatory bowel diseases and rheumatoid arthritis) as well as their potential benefits on neurodegenerative diseases. It is well established that n-3 LC-PUFAs are substrates for synthesis of novel series of lipid mediators (e.g., resolvins, protectins, and maresins) with potent anti-inflammatory and pro-resolving properties, which have been proposed to partly mediate the protective and beneficial actions of n-3 LC-PUFAs. Here, we briefly summarize current knowledge from preclinical studies analyzing the actions of EPA- and DHA-derived resolvins and protectins on pathophysiological models of rheumatoid arthritis, Alzheimer, and irritable bowel syndrome.

Authors+Show Affiliations

Department of Nutrition, Food Science and Physiology and Center for Nutrition Research, University of Navarra, 31008, Pamplona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25752887

Citation

Lorente-Cebrián, Silvia, et al. "An Update On the Role of Omega-3 Fatty Acids On Inflammatory and Degenerative Diseases." Journal of Physiology and Biochemistry, vol. 71, no. 2, 2015, pp. 341-9.
Lorente-Cebrián S, Costa AG, Navas-Carretero S, et al. An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases. J Physiol Biochem. 2015;71(2):341-9.
Lorente-Cebrián, S., Costa, A. G., Navas-Carretero, S., Zabala, M., Laiglesia, L. M., Martínez, J. A., & Moreno-Aliaga, M. J. (2015). An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases. Journal of Physiology and Biochemistry, 71(2), pp. 341-9. doi:10.1007/s13105-015-0395-y.
Lorente-Cebrián S, et al. An Update On the Role of Omega-3 Fatty Acids On Inflammatory and Degenerative Diseases. J Physiol Biochem. 2015;71(2):341-9. PubMed PMID: 25752887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases. AU - Lorente-Cebrián,Silvia, AU - Costa,André G V, AU - Navas-Carretero,Santiago, AU - Zabala,María, AU - Laiglesia,Laura M, AU - Martínez,J Alfredo, AU - Moreno-Aliaga,María J, Y1 - 2015/03/11/ PY - 2014/12/19/received PY - 2015/02/19/accepted PY - 2015/3/11/entrez PY - 2015/3/11/pubmed PY - 2016/2/18/medline SP - 341 EP - 9 JF - Journal of physiology and biochemistry JO - J. Physiol. Biochem. VL - 71 IS - 2 N2 - Inflammation is involved in the pathophysiology of many chronic diseases, such as rheumatoid arthritis and neurodegenerative diseases. Several studies have evidenced important anti-inflammatory and immunomodulatory properties of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs). This review illustrates current knowledge about the efficacy of n-3 LC-PUFAs (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), particularly) in preventing and/or treating several chronic inflammatory conditions (inflammatory bowel diseases and rheumatoid arthritis) as well as their potential benefits on neurodegenerative diseases. It is well established that n-3 LC-PUFAs are substrates for synthesis of novel series of lipid mediators (e.g., resolvins, protectins, and maresins) with potent anti-inflammatory and pro-resolving properties, which have been proposed to partly mediate the protective and beneficial actions of n-3 LC-PUFAs. Here, we briefly summarize current knowledge from preclinical studies analyzing the actions of EPA- and DHA-derived resolvins and protectins on pathophysiological models of rheumatoid arthritis, Alzheimer, and irritable bowel syndrome. SN - 1877-8755 UR - https://www.unboundmedicine.com/medline/citation/25752887/An_update_on_the_role_of_omega_3_fatty_acids_on_inflammatory_and_degenerative_diseases_ L2 - https://dx.doi.org/10.1007/s13105-015-0395-y DB - PRIME DP - Unbound Medicine ER -