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Red peppers with moderate and severe pungency prevent the memory deficit and hepatic insulin resistance in diabetic rats with Alzheimer's disease.
Nutr Metab (Lond) 2015; 12:9NM

Abstract

BACKGROUND

Dementia induced by β-amyloid accumulation impairs peripheral glucose homeostasis, but red pepper extract improves glucose homeostasis. We therefore evaluated whether long-term oral consumption of different red pepper extracts improves cognitive dysfunction and glucose homeostasis in type 2 diabetic rats with β-amyloid-induced dementia.

METHODS

Male diabetic rats received hippocampal CA1 infusions of β-amyloid (25-35) (AD) or β-amyloid (35-25, non-plaque forming), at a rate of 3.6 nmol/day for 14 days (Non-AD). AD rats were divided into four dietary groups receiving either 1% lyophilized 70% ethanol extracts of either low, moderate and severe pungency red peppers (AD-LP, AD-MP, and AD-SP) or 1% dextrin (AD-CON) in Western diets (43% energy as fat).

RESULTS

The ascending order of control < LSP < MSP and SSP potentiated the phosphorylation of CREB and GSK and inhibited Tau phosphorylation in the hippocampus which in turn inhibited β-amyloid accumulation. The inhibition by MP and SP reduced the memory deficit measured by passive avoidance test and water maze test. Furthermore, the accumulation of β-amyloid induced glucose intolerance, although serum insulin levels were elevated during the late phase of oral glucose tolerance test (OGTT). All of the red pepper extracts prevented the glucose intolerance in AD rats. Consistent with OGTT results, during euglycemic hyperinulinemic clamp glucose infusion rates were lower in AD-CON than Non-AD-CON with no difference in whole body glucose uptake. Hepatic glucose output at the hyperinsulinemic state was increased in AD-CON. β-amyloid accumulation exacerbated hepatic insulin resistance, but all red pepper extract treatments reversed the insulin resistance in AD rats.

CONCLUSIONS

The extracts of moderate and severe red peppers were found to prevent the memory deficit and exacerbation of insulin resistance by blocking tau phosphorylation and β-amyloid accumulation in diabetic rats with experimentally induced Alzheimer's-like dementia. These results suggest that red pepper consumption might be an effective intervention for preventing age-related memory deficit.

Authors+Show Affiliations

Division of Metabolism and Functionality Research, Korean Food Research Institutes, Sungnam, South Korea.Division of Metabolism and Functionality Research, Korean Food Research Institutes, Sungnam, South Korea.Division of Metabolism and Functionality Research, Korean Food Research Institutes, Sungnam, South Korea.Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, 165 Sechul-Ri, BaeBang-Yup, Asan-Si, ChungNam-Do 336-795 South Korea.Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, 165 Sechul-Ri, BaeBang-Yup, Asan-Si, ChungNam-Do 336-795 South Korea.Daily Manufacturing Inc., Rockwell, NC USA.Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, 165 Sechul-Ri, BaeBang-Yup, Asan-Si, ChungNam-Do 336-795 South Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25755673

Citation

Yang, Hye Jeong, et al. "Red Peppers With Moderate and Severe Pungency Prevent the Memory Deficit and Hepatic Insulin Resistance in Diabetic Rats With Alzheimer's Disease." Nutrition & Metabolism, vol. 12, 2015, p. 9.
Yang HJ, Kwon DY, Kim MJ, et al. Red peppers with moderate and severe pungency prevent the memory deficit and hepatic insulin resistance in diabetic rats with Alzheimer's disease. Nutr Metab (Lond). 2015;12:9.
Yang, H. J., Kwon, D. Y., Kim, M. J., Kang, S., Moon, N. R., Daily, J. W., & Park, S. (2015). Red peppers with moderate and severe pungency prevent the memory deficit and hepatic insulin resistance in diabetic rats with Alzheimer's disease. Nutrition & Metabolism, 12, p. 9. doi:10.1186/s12986-015-0005-6.
Yang HJ, et al. Red Peppers With Moderate and Severe Pungency Prevent the Memory Deficit and Hepatic Insulin Resistance in Diabetic Rats With Alzheimer's Disease. Nutr Metab (Lond). 2015;12:9. PubMed PMID: 25755673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red peppers with moderate and severe pungency prevent the memory deficit and hepatic insulin resistance in diabetic rats with Alzheimer's disease. AU - Yang,Hye Jeong, AU - Kwon,Dae Young, AU - Kim,Min Jung, AU - Kang,Suna, AU - Moon,Na Rang, AU - Daily,James W, AU - Park,Sunmin, Y1 - 2015/03/08/ PY - 2014/11/22/received PY - 2015/02/12/accepted PY - 2015/3/11/entrez PY - 2015/3/11/pubmed PY - 2015/3/11/medline KW - Alzheimer’s disease KW - Insulin resistance KW - Insulin secretion KW - Pungency KW - Red pepper SP - 9 EP - 9 JF - Nutrition & metabolism JO - Nutr Metab (Lond) VL - 12 N2 - BACKGROUND: Dementia induced by β-amyloid accumulation impairs peripheral glucose homeostasis, but red pepper extract improves glucose homeostasis. We therefore evaluated whether long-term oral consumption of different red pepper extracts improves cognitive dysfunction and glucose homeostasis in type 2 diabetic rats with β-amyloid-induced dementia. METHODS: Male diabetic rats received hippocampal CA1 infusions of β-amyloid (25-35) (AD) or β-amyloid (35-25, non-plaque forming), at a rate of 3.6 nmol/day for 14 days (Non-AD). AD rats were divided into four dietary groups receiving either 1% lyophilized 70% ethanol extracts of either low, moderate and severe pungency red peppers (AD-LP, AD-MP, and AD-SP) or 1% dextrin (AD-CON) in Western diets (43% energy as fat). RESULTS: The ascending order of control < LSP < MSP and SSP potentiated the phosphorylation of CREB and GSK and inhibited Tau phosphorylation in the hippocampus which in turn inhibited β-amyloid accumulation. The inhibition by MP and SP reduced the memory deficit measured by passive avoidance test and water maze test. Furthermore, the accumulation of β-amyloid induced glucose intolerance, although serum insulin levels were elevated during the late phase of oral glucose tolerance test (OGTT). All of the red pepper extracts prevented the glucose intolerance in AD rats. Consistent with OGTT results, during euglycemic hyperinulinemic clamp glucose infusion rates were lower in AD-CON than Non-AD-CON with no difference in whole body glucose uptake. Hepatic glucose output at the hyperinsulinemic state was increased in AD-CON. β-amyloid accumulation exacerbated hepatic insulin resistance, but all red pepper extract treatments reversed the insulin resistance in AD rats. CONCLUSIONS: The extracts of moderate and severe red peppers were found to prevent the memory deficit and exacerbation of insulin resistance by blocking tau phosphorylation and β-amyloid accumulation in diabetic rats with experimentally induced Alzheimer's-like dementia. These results suggest that red pepper consumption might be an effective intervention for preventing age-related memory deficit. SN - 1743-7075 UR - https://www.unboundmedicine.com/medline/citation/25755673/Red_peppers_with_moderate_and_severe_pungency_prevent_the_memory_deficit_and_hepatic_insulin_resistance_in_diabetic_rats_with_Alzheimer's_disease_ L2 - https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-015-0005-6 DB - PRIME DP - Unbound Medicine ER -