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Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazol-kindled rats.
Neuropeptides. 1989 Oct; 14(3):197-207.N

Abstract

We studied the effect of pentylenetetrazol (PTZ)-induced kindling (35 mg/kg, i.p., daily) on somatostatin-like immunoreactivity (SOM) with special attention to the duration of changes (rats were sacrificed either 10 days or 4 months after the development of kindling) and to transmitters or modulators related to somatostatin (neuropeptide Y (NPY), GABA, choline acetyltransferase (ChAT), acetylcholinesterase (AchE]. In rats sacrificed 10 days after the last kindled seizure, SOM was elevated in frontal cortex and striatum (p less than 0.01); NPY was elevated in frontal cortex, striatum and hippocampus (p less than 0.05) of kindled or prekindled rats (i.e., rats which were treated daily with PTZ but did not express three consecutive generalized seizures). ChAT activity was slightly decreased (p less than 0.05) in cortex. GABA levels and AchE activity were unchanged in kindled cortex. In rats sacrificed 4 months after the development of kindling none of the parameters analyzed differed from controls. The present study suggests that the cortical and striatal neurons containing SOM/NPY are affected by PTZ-kindling. The cortical cholinergic system is affected to a much smaller extent. The neuropeptide changes are not persistent, as is the lowered seizure threshold, so they are probably not involved in the maintainance of the latter.

Authors+Show Affiliations

Pitkänen A
Department of Neurology, University of Kuopio, Finland.
Beal MF
No affiliation info available
Sirviö J
No affiliation info available
Swartz KJ
No affiliation info available
Männistö PT
No affiliation info available
Riekkinen PJ
No affiliation info available

MeSH

AcetylcholinesteraseAnimalsBrainCholine O-AcetyltransferaseKindling, NeurologicKineticsMaleNeuropeptide YPentylenetetrazoleRatsRats, Inbred StrainsSomatostatinTissue Distributiongamma-Aminobutyric Acid

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2575717

Citation

Pitkänen, A, et al. "Somatostatin, Neuropeptide Y, GABA and Cholinergic Enzymes in Brain of Pentylenetetrazol-kindled Rats." Neuropeptides, vol. 14, no. 3, 1989, pp. 197-207.
Pitkänen A, Beal MF, Sirviö J, et al. Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazol-kindled rats. Neuropeptides. 1989;14(3):197-207.
Pitkänen, A., Beal, M. F., Sirviö, J., Swartz, K. J., Männistö, P. T., & Riekkinen, P. J. (1989). Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazol-kindled rats. Neuropeptides, 14(3), 197-207.
Pitkänen A, et al. Somatostatin, Neuropeptide Y, GABA and Cholinergic Enzymes in Brain of Pentylenetetrazol-kindled Rats. Neuropeptides. 1989;14(3):197-207. PubMed PMID: 2575717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazol-kindled rats. AU - Pitkänen,A, AU - Beal,M F, AU - Sirviö,J, AU - Swartz,K J, AU - Männistö,P T, AU - Riekkinen,P J, PY - 1989/10/1/pubmed PY - 1989/10/1/medline PY - 1989/10/1/entrez SP - 197 EP - 207 JF - Neuropeptides JO - Neuropeptides VL - 14 IS - 3 N2 - We studied the effect of pentylenetetrazol (PTZ)-induced kindling (35 mg/kg, i.p., daily) on somatostatin-like immunoreactivity (SOM) with special attention to the duration of changes (rats were sacrificed either 10 days or 4 months after the development of kindling) and to transmitters or modulators related to somatostatin (neuropeptide Y (NPY), GABA, choline acetyltransferase (ChAT), acetylcholinesterase (AchE]. In rats sacrificed 10 days after the last kindled seizure, SOM was elevated in frontal cortex and striatum (p less than 0.01); NPY was elevated in frontal cortex, striatum and hippocampus (p less than 0.05) of kindled or prekindled rats (i.e., rats which were treated daily with PTZ but did not express three consecutive generalized seizures). ChAT activity was slightly decreased (p less than 0.05) in cortex. GABA levels and AchE activity were unchanged in kindled cortex. In rats sacrificed 4 months after the development of kindling none of the parameters analyzed differed from controls. The present study suggests that the cortical and striatal neurons containing SOM/NPY are affected by PTZ-kindling. The cortical cholinergic system is affected to a much smaller extent. The neuropeptide changes are not persistent, as is the lowered seizure threshold, so they are probably not involved in the maintainance of the latter. SN - 0143-4179 UR - https://www.unboundmedicine.com/medline/citation/2575717/Somatostatin_neuropeptide_Y_GABA_and_cholinergic_enzymes_in_brain_of_pentylenetetrazol_kindled_rats_ DB - PRIME DP - Unbound Medicine ER -