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Cardiac valve calcification is associated with presence and severity of coronary artery disease in patients with pre-dialysis chronic kidney disease.
Clin Exp Nephrol. 2015 Dec; 19(6):1090-7.CE

Abstract

BACKGROUND

Cardiac valve calcification is common in chronic kidney disease (CKD) patients. Coronary artery disease (CAD) is the one of major causes for increased cardiovascular mortality in CKD patients. We hypothesized that cardiac valve calcification is associated with the presence and the severity of CAD in pre-dialysis CKD patients.

METHODS

This study included 1166 patients who underwent transthoracic echocardiography for assessment of cardiac valve calcification and coronary angiography for assessment of CAD. The patients were divided into two groups according to estimated glomerular filtration rate (eGFR): pre-dialysis CKD group (n = 215, eGFR < 60 ml/min/1.73 m(2)) and non-CKD group (n = 951, eGFR ≥ 60 ml/min/1.73 m(2)).

RESULTS

In the pre-dialysis CKD group, subjects with aortic valve calcification (AVC), mitral valve calcification (MVC), and at least one valve calcification had more severe CAD compared with those without AVC, MVC, and any valve calcification. Multivariate analysis showed that pre-dialysis CKD patients who had AVC, MVC, and at least one valve calcification were 3.02 times (P = 0.033), 3.73 times (P = 0.029), and 3.31 times (P = 0.012) more likely to have CAD compared with those without AVC, MVC, and any valve calcification, respectively. However, in the non-CKD group, there was no association between cardiac valve calcification and the severity/presence of CAD.

CONCLUSIONS

Cardiac valve calcification is associated with the presence and severity of CAD in pre-dialysis CKD. Assessment of cardiac valve calcification by means of transthoracic echocardiography could be a valuable non-invasive method for CAD risk stratification in pre-dialysis CKD patients.

Authors+Show Affiliations

Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, 626-770, Gyeongsangnam-do, South Korea. Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea.Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, 626-770, Gyeongsangnam-do, South Korea. Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea.Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, 626-770, Gyeongsangnam-do, South Korea. Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea.Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, 626-770, Gyeongsangnam-do, South Korea. sbleemd@pusan.ac.kr. Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea. sbleemd@pusan.ac.kr.Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, 626-770, Gyeongsangnam-do, South Korea. Medical Research Institute, Pusan National University Hospital, Busan, South Korea.Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, 626-770, Gyeongsangnam-do, South Korea. Medical Research Institute, Pusan National University Hospital, Busan, South Korea.Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, 626-770, Gyeongsangnam-do, South Korea. Medical Research Institute, Pusan National University Hospital, Busan, South Korea.Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, 626-770, Gyeongsangnam-do, South Korea. Medical Research Institute, Pusan National University Hospital, Busan, South Korea.Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, 626-770, Gyeongsangnam-do, South Korea. Medical Research Institute, Pusan National University Hospital, Busan, South Korea.Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, 626-770, Gyeongsangnam-do, South Korea. Medical Research Institute, Pusan National University Hospital, Busan, South Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25757535

Citation

Kim, Il Young, et al. "Cardiac Valve Calcification Is Associated With Presence and Severity of Coronary Artery Disease in Patients With Pre-dialysis Chronic Kidney Disease." Clinical and Experimental Nephrology, vol. 19, no. 6, 2015, pp. 1090-7.
Kim IY, Kim MJ, Lee DW, et al. Cardiac valve calcification is associated with presence and severity of coronary artery disease in patients with pre-dialysis chronic kidney disease. Clin Exp Nephrol. 2015;19(6):1090-7.
Kim, I. Y., Kim, M. J., Lee, D. W., Lee, S. B., Shin, M. J., Rhee, H., Yang, B. Y., Song, S. H., Seong, E. Y., & Kwak, I. S. (2015). Cardiac valve calcification is associated with presence and severity of coronary artery disease in patients with pre-dialysis chronic kidney disease. Clinical and Experimental Nephrology, 19(6), 1090-7. https://doi.org/10.1007/s10157-015-1104-4
Kim IY, et al. Cardiac Valve Calcification Is Associated With Presence and Severity of Coronary Artery Disease in Patients With Pre-dialysis Chronic Kidney Disease. Clin Exp Nephrol. 2015;19(6):1090-7. PubMed PMID: 25757535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac valve calcification is associated with presence and severity of coronary artery disease in patients with pre-dialysis chronic kidney disease. AU - Kim,Il Young, AU - Kim,Min Jung, AU - Lee,Dong Won, AU - Lee,Soo Bong, AU - Shin,Min Ji, AU - Rhee,Harin, AU - Yang,Byeong Yun, AU - Song,Sang Heon, AU - Seong,Eun Young, AU - Kwak,Ihm Soo, Y1 - 2015/03/12/ PY - 2014/09/04/received PY - 2015/02/25/accepted PY - 2015/3/12/entrez PY - 2015/3/12/pubmed PY - 2016/9/20/medline KW - Cardiac valve calcification KW - Chronic kidney disease KW - Coronary artery disease SP - 1090 EP - 7 JF - Clinical and experimental nephrology JO - Clin Exp Nephrol VL - 19 IS - 6 N2 - BACKGROUND: Cardiac valve calcification is common in chronic kidney disease (CKD) patients. Coronary artery disease (CAD) is the one of major causes for increased cardiovascular mortality in CKD patients. We hypothesized that cardiac valve calcification is associated with the presence and the severity of CAD in pre-dialysis CKD patients. METHODS: This study included 1166 patients who underwent transthoracic echocardiography for assessment of cardiac valve calcification and coronary angiography for assessment of CAD. The patients were divided into two groups according to estimated glomerular filtration rate (eGFR): pre-dialysis CKD group (n = 215, eGFR < 60 ml/min/1.73 m(2)) and non-CKD group (n = 951, eGFR ≥ 60 ml/min/1.73 m(2)). RESULTS: In the pre-dialysis CKD group, subjects with aortic valve calcification (AVC), mitral valve calcification (MVC), and at least one valve calcification had more severe CAD compared with those without AVC, MVC, and any valve calcification. Multivariate analysis showed that pre-dialysis CKD patients who had AVC, MVC, and at least one valve calcification were 3.02 times (P = 0.033), 3.73 times (P = 0.029), and 3.31 times (P = 0.012) more likely to have CAD compared with those without AVC, MVC, and any valve calcification, respectively. However, in the non-CKD group, there was no association between cardiac valve calcification and the severity/presence of CAD. CONCLUSIONS: Cardiac valve calcification is associated with the presence and severity of CAD in pre-dialysis CKD. Assessment of cardiac valve calcification by means of transthoracic echocardiography could be a valuable non-invasive method for CAD risk stratification in pre-dialysis CKD patients. SN - 1437-7799 UR - https://www.unboundmedicine.com/medline/citation/25757535/Cardiac_valve_calcification_is_associated_with_presence_and_severity_of_coronary_artery_disease_in_patients_with_pre_dialysis_chronic_kidney_disease_ L2 - https://dx.doi.org/10.1007/s10157-015-1104-4 DB - PRIME DP - Unbound Medicine ER -