Tags

Type your tag names separated by a space and hit enter

The impact of two semiannual treatments with albendazole alone on lymphatic filariasis and soil-transmitted helminth infections: a community-based study in the Republic of Congo.
Am J Trop Med Hyg. 2015 May; 92(5):959-66.AJ

Abstract

Implementation of mass drug administration (MDA) with ivermectin plus albendazole (ALB) for lymphatic filariasis (LF) has been delayed in central Africa because of the risk of serious adverse events in subjects with high Loa loa microfilaremia. We conducted a community trial to assess the impact of semiannual MDA with ALB (400 mg) alone on LF and soil-transmitted helminth (STH) infections in the Republic of Congo. Evaluation at 12 months showed that ALB MDA had not significantly reduced Wuchereria bancrofti antigenemia or microfilaria (mf) rates in the community (from 17.3% to 16.6% and from 5.3% to 4.2%, respectively). However, the geometric mean mf count in mf-positive subjects was reduced from 202.2 to 80.9 mf/mL (60% reduction, P = 0.01). The effect of ALB was impressive in 38 subjects who were mf-positive at baseline and retested at 12 months: 37% had total mf clearance, and individual mf densities were reduced by 73.0%. MDA also dramatically reduced the hookworm infection rate in the community from 6.5% to 0.6% (91% reduction), with less impressive effects on Ascaris and Trichuris. These preliminary results suggest that semiannual community MDA with ALB is a promising strategy for controlling LF and STH in areas with coendemic loiasis.

Authors+Show Affiliations

Unité Mixte Internationale 233, Institut de Recherche pour le Développement and University of Montpellier 1, Montpellier, France; Centre for Research on Filariasis and Other Tropical Diseases (CRFilMT), Yaoundé, Cameroon; Programme National de Lutte contre l'Onchocercose, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo; Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri sebastien.pion@ird.fr.Unité Mixte Internationale 233, Institut de Recherche pour le Développement and University of Montpellier 1, Montpellier, France; Centre for Research on Filariasis and Other Tropical Diseases (CRFilMT), Yaoundé, Cameroon; Programme National de Lutte contre l'Onchocercose, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo; Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.Unité Mixte Internationale 233, Institut de Recherche pour le Développement and University of Montpellier 1, Montpellier, France; Centre for Research on Filariasis and Other Tropical Diseases (CRFilMT), Yaoundé, Cameroon; Programme National de Lutte contre l'Onchocercose, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo; Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.Unité Mixte Internationale 233, Institut de Recherche pour le Développement and University of Montpellier 1, Montpellier, France; Centre for Research on Filariasis and Other Tropical Diseases (CRFilMT), Yaoundé, Cameroon; Programme National de Lutte contre l'Onchocercose, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo; Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.Unité Mixte Internationale 233, Institut de Recherche pour le Développement and University of Montpellier 1, Montpellier, France; Centre for Research on Filariasis and Other Tropical Diseases (CRFilMT), Yaoundé, Cameroon; Programme National de Lutte contre l'Onchocercose, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo; Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.Unité Mixte Internationale 233, Institut de Recherche pour le Développement and University of Montpellier 1, Montpellier, France; Centre for Research on Filariasis and Other Tropical Diseases (CRFilMT), Yaoundé, Cameroon; Programme National de Lutte contre l'Onchocercose, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo; Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.Unité Mixte Internationale 233, Institut de Recherche pour le Développement and University of Montpellier 1, Montpellier, France; Centre for Research on Filariasis and Other Tropical Diseases (CRFilMT), Yaoundé, Cameroon; Programme National de Lutte contre l'Onchocercose, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo; Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.Unité Mixte Internationale 233, Institut de Recherche pour le Développement and University of Montpellier 1, Montpellier, France; Centre for Research on Filariasis and Other Tropical Diseases (CRFilMT), Yaoundé, Cameroon; Programme National de Lutte contre l'Onchocercose, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo; Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.Unité Mixte Internationale 233, Institut de Recherche pour le Développement and University of Montpellier 1, Montpellier, France; Centre for Research on Filariasis and Other Tropical Diseases (CRFilMT), Yaoundé, Cameroon; Programme National de Lutte contre l'Onchocercose, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo; Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25758650

Citation

Pion, Sébastien D S., et al. "The Impact of Two Semiannual Treatments With Albendazole Alone On Lymphatic Filariasis and Soil-transmitted Helminth Infections: a Community-based Study in the Republic of Congo." The American Journal of Tropical Medicine and Hygiene, vol. 92, no. 5, 2015, pp. 959-66.
Pion SD, Chesnais CB, Bopda J, et al. The impact of two semiannual treatments with albendazole alone on lymphatic filariasis and soil-transmitted helminth infections: a community-based study in the Republic of Congo. Am J Trop Med Hyg. 2015;92(5):959-66.
Pion, S. D., Chesnais, C. B., Bopda, J., Louya, F., Fischer, P. U., Majewski, A. C., Weil, G. J., Boussinesq, M., & Missamou, F. (2015). The impact of two semiannual treatments with albendazole alone on lymphatic filariasis and soil-transmitted helminth infections: a community-based study in the Republic of Congo. The American Journal of Tropical Medicine and Hygiene, 92(5), 959-66. https://doi.org/10.4269/ajtmh.14-0661
Pion SD, et al. The Impact of Two Semiannual Treatments With Albendazole Alone On Lymphatic Filariasis and Soil-transmitted Helminth Infections: a Community-based Study in the Republic of Congo. Am J Trop Med Hyg. 2015;92(5):959-66. PubMed PMID: 25758650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of two semiannual treatments with albendazole alone on lymphatic filariasis and soil-transmitted helminth infections: a community-based study in the Republic of Congo. AU - Pion,Sébastien D S, AU - Chesnais,Cédric B, AU - Bopda,Jean, AU - Louya,Frédéric, AU - Fischer,Peter U, AU - Majewski,Andrew C, AU - Weil,Gary J, AU - Boussinesq,Michel, AU - Missamou,François, Y1 - 2015/03/09/ PY - 2014/10/20/received PY - 2014/12/09/accepted PY - 2015/3/12/entrez PY - 2015/3/12/pubmed PY - 2015/8/20/medline SP - 959 EP - 66 JF - The American journal of tropical medicine and hygiene JO - Am. J. Trop. Med. Hyg. VL - 92 IS - 5 N2 - Implementation of mass drug administration (MDA) with ivermectin plus albendazole (ALB) for lymphatic filariasis (LF) has been delayed in central Africa because of the risk of serious adverse events in subjects with high Loa loa microfilaremia. We conducted a community trial to assess the impact of semiannual MDA with ALB (400 mg) alone on LF and soil-transmitted helminth (STH) infections in the Republic of Congo. Evaluation at 12 months showed that ALB MDA had not significantly reduced Wuchereria bancrofti antigenemia or microfilaria (mf) rates in the community (from 17.3% to 16.6% and from 5.3% to 4.2%, respectively). However, the geometric mean mf count in mf-positive subjects was reduced from 202.2 to 80.9 mf/mL (60% reduction, P = 0.01). The effect of ALB was impressive in 38 subjects who were mf-positive at baseline and retested at 12 months: 37% had total mf clearance, and individual mf densities were reduced by 73.0%. MDA also dramatically reduced the hookworm infection rate in the community from 6.5% to 0.6% (91% reduction), with less impressive effects on Ascaris and Trichuris. These preliminary results suggest that semiannual community MDA with ALB is a promising strategy for controlling LF and STH in areas with coendemic loiasis. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/25758650/The_impact_of_two_semiannual_treatments_with_albendazole_alone_on_lymphatic_filariasis_and_soil_transmitted_helminth_infections:_a_community_based_study_in_the_Republic_of_Congo_ L2 - http://www.ajtmh.org/content/journals/10.4269/ajtmh.14-0661?crawler=true&mimetype=application/pdf DB - PRIME DP - Unbound Medicine ER -