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Association of Serum Heavy Metals and Trace Element Concentrations with Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population.

Abstract

To investigate the serum concentrations of 11 heavy metals and trace elements in patients with polycystic ovary syndrome (PCOS). A total of 369 women (including 96 patients with PCOS) were studied. No differences with statistical significance in the median barium, cadmium, lead, arsenic, chromium, gallium, strontium, and vanadium concentrations were observed between the patients with PCOS and the control group. Serum nickel (Ni) (P = 0.000) and copper (Cu) (P = 0.000) levels were significantly higher, but zinc (Zn) levels (P = 0.009) were significantly lower in patients with PCOS compared with the control group. The results of the association between metal levels and hormone levels indicated that Ni, Cu, and Zn may play a role in the pathogenesis of PCOS related with reproductive hormone levels. The findings in the present study should be investigated with further trials in order to obtain new insights into PCOS.

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  • Authors+Show Affiliations

    ,

    State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, 361102, China.

    , , , , , ,

    Source

    Biological trace element research 167:1 2015 Sep pg 1-10

    MeSH

    Adult
    Asian Continental Ancestry Group
    China
    Copper
    Estradiol
    Female
    Follicle Stimulating Hormone
    Hormones
    Humans
    Linear Models
    Luteinizing Hormone
    Metals, Heavy
    Nickel
    Polycystic Ovary Syndrome
    Progesterone
    Prolactin
    Testosterone
    Trace Elements
    Zinc

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25758722

    Citation

    Zheng, Guanchao, et al. "Association of Serum Heavy Metals and Trace Element Concentrations With Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population." Biological Trace Element Research, vol. 167, no. 1, 2015, pp. 1-10.
    Zheng G, Wang L, Guo Z, et al. Association of Serum Heavy Metals and Trace Element Concentrations with Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population. Biol Trace Elem Res. 2015;167(1):1-10.
    Zheng, G., Wang, L., Guo, Z., Sun, L., Wang, L., Wang, C., ... Qiu, H. (2015). Association of Serum Heavy Metals and Trace Element Concentrations with Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population. Biological Trace Element Research, 167(1), pp. 1-10. doi:10.1007/s12011-015-0294-7.
    Zheng G, et al. Association of Serum Heavy Metals and Trace Element Concentrations With Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population. Biol Trace Elem Res. 2015;167(1):1-10. PubMed PMID: 25758722.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of Serum Heavy Metals and Trace Element Concentrations with Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population. AU - Zheng,Guanchao, AU - Wang,Lijun, AU - Guo,Zhizhun, AU - Sun,Lingbin, AU - Wang,Lingling, AU - Wang,Chonggang, AU - Zuo,Zhenghong, AU - Qiu,Huiling, Y1 - 2015/03/12/ PY - 2014/12/15/received PY - 2015/03/02/accepted PY - 2015/3/12/entrez PY - 2015/3/12/pubmed PY - 2016/4/26/medline SP - 1 EP - 10 JF - Biological trace element research JO - Biol Trace Elem Res VL - 167 IS - 1 N2 - To investigate the serum concentrations of 11 heavy metals and trace elements in patients with polycystic ovary syndrome (PCOS). A total of 369 women (including 96 patients with PCOS) were studied. No differences with statistical significance in the median barium, cadmium, lead, arsenic, chromium, gallium, strontium, and vanadium concentrations were observed between the patients with PCOS and the control group. Serum nickel (Ni) (P = 0.000) and copper (Cu) (P = 0.000) levels were significantly higher, but zinc (Zn) levels (P = 0.009) were significantly lower in patients with PCOS compared with the control group. The results of the association between metal levels and hormone levels indicated that Ni, Cu, and Zn may play a role in the pathogenesis of PCOS related with reproductive hormone levels. The findings in the present study should be investigated with further trials in order to obtain new insights into PCOS. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/25758722/Association_of_Serum_Heavy_Metals_and_Trace_Element_Concentrations_with_Reproductive_Hormone_Levels_and_Polycystic_Ovary_Syndrome_in_a_Chinese_Population_ L2 - https://dx.doi.org/10.1007/s12011-015-0294-7 DB - PRIME DP - Unbound Medicine ER -