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Association of Serum Heavy Metals and Trace Element Concentrations with Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population.
Biol Trace Elem Res 2015; 167(1):1-10BT

Abstract

To investigate the serum concentrations of 11 heavy metals and trace elements in patients with polycystic ovary syndrome (PCOS). A total of 369 women (including 96 patients with PCOS) were studied. No differences with statistical significance in the median barium, cadmium, lead, arsenic, chromium, gallium, strontium, and vanadium concentrations were observed between the patients with PCOS and the control group. Serum nickel (Ni) (P = 0.000) and copper (Cu) (P = 0.000) levels were significantly higher, but zinc (Zn) levels (P = 0.009) were significantly lower in patients with PCOS compared with the control group. The results of the association between metal levels and hormone levels indicated that Ni, Cu, and Zn may play a role in the pathogenesis of PCOS related with reproductive hormone levels. The findings in the present study should be investigated with further trials in order to obtain new insights into PCOS.

Authors+Show Affiliations

State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, 361102, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25758722

Citation

Zheng, Guanchao, et al. "Association of Serum Heavy Metals and Trace Element Concentrations With Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population." Biological Trace Element Research, vol. 167, no. 1, 2015, pp. 1-10.
Zheng G, Wang L, Guo Z, et al. Association of Serum Heavy Metals and Trace Element Concentrations with Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population. Biol Trace Elem Res. 2015;167(1):1-10.
Zheng, G., Wang, L., Guo, Z., Sun, L., Wang, L., Wang, C., ... Qiu, H. (2015). Association of Serum Heavy Metals and Trace Element Concentrations with Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population. Biological Trace Element Research, 167(1), pp. 1-10. doi:10.1007/s12011-015-0294-7.
Zheng G, et al. Association of Serum Heavy Metals and Trace Element Concentrations With Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population. Biol Trace Elem Res. 2015;167(1):1-10. PubMed PMID: 25758722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Serum Heavy Metals and Trace Element Concentrations with Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population. AU - Zheng,Guanchao, AU - Wang,Lijun, AU - Guo,Zhizhun, AU - Sun,Lingbin, AU - Wang,Lingling, AU - Wang,Chonggang, AU - Zuo,Zhenghong, AU - Qiu,Huiling, Y1 - 2015/03/12/ PY - 2014/12/15/received PY - 2015/03/02/accepted PY - 2015/3/12/entrez PY - 2015/3/12/pubmed PY - 2016/4/26/medline SP - 1 EP - 10 JF - Biological trace element research JO - Biol Trace Elem Res VL - 167 IS - 1 N2 - To investigate the serum concentrations of 11 heavy metals and trace elements in patients with polycystic ovary syndrome (PCOS). A total of 369 women (including 96 patients with PCOS) were studied. No differences with statistical significance in the median barium, cadmium, lead, arsenic, chromium, gallium, strontium, and vanadium concentrations were observed between the patients with PCOS and the control group. Serum nickel (Ni) (P = 0.000) and copper (Cu) (P = 0.000) levels were significantly higher, but zinc (Zn) levels (P = 0.009) were significantly lower in patients with PCOS compared with the control group. The results of the association between metal levels and hormone levels indicated that Ni, Cu, and Zn may play a role in the pathogenesis of PCOS related with reproductive hormone levels. The findings in the present study should be investigated with further trials in order to obtain new insights into PCOS. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/25758722/Association_of_Serum_Heavy_Metals_and_Trace_Element_Concentrations_with_Reproductive_Hormone_Levels_and_Polycystic_Ovary_Syndrome_in_a_Chinese_Population_ L2 - https://dx.doi.org/10.1007/s12011-015-0294-7 DB - PRIME DP - Unbound Medicine ER -