Tags

Type your tag names separated by a space and hit enter

New Generation of Orally Disintegrating Tablets for Sustained Drug Release: A Propitious Outlook.
Curr Drug Deliv. 2015; 12(6):652-67.CD

Abstract

Orally disintegrating tablets (ODTs) or orodispersible tablets are solid dosage forms that disintegrate within 3 minutes in the mouth into a paste that can be easily swallowed. ODTs have improved over the past years, in an attempt to produce a safe and efficient substitute to the conventional oral dosage forms, particularly for dysphagia patients. Since its introduction in the market in the 1980s, ODTs expanded rapidly and achieved revenues over $3 billion in 2006 and sustaining 20% annual growth. It is therefore evident that ODTs carry good commercial value, however there is potential for improvement. Current sustained-release technologies may be exploited and incorporated into an ODT to provide greater therapeutic value by reducing the need for multiple daily dosing regimens and improving patient adherence. A number of technologies such as polymer coated nanoparticles, stimuli-responsive polymers and ion-exchange resins have emerged to produce robust, sustained release orally disintegrating tablets (SR-ODT). The purpose of this review is to highlight these various approaches and techniques and how they have been utilised in an ODT formulation to extend differentiated line, market exclusivity and patent life. The review also explores future perspective and the potential challenges that SR-ODTs will face.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableDrug Discovery, Delivery and Patient Care (DDDPC), School of Pharmacy and Chemistry, Kingston University London, Penrhyn Road, Kingston Upon Thames, Surrey, KT1 2EE, UK. a.elshaer@kingston.ac.uk.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25760951

Citation

Elwerfalli, Arwa Matoug, et al. "New Generation of Orally Disintegrating Tablets for Sustained Drug Release: a Propitious Outlook." Current Drug Delivery, vol. 12, no. 6, 2015, pp. 652-67.
Elwerfalli AM, Ghanchi Z, Rashid F, et al. New Generation of Orally Disintegrating Tablets for Sustained Drug Release: A Propitious Outlook. Curr Drug Deliv. 2015;12(6):652-67.
Elwerfalli, A. M., Ghanchi, Z., Rashid, F., Alany, R. G., & ElShaer, A. (2015). New Generation of Orally Disintegrating Tablets for Sustained Drug Release: A Propitious Outlook. Current Drug Delivery, 12(6), 652-67.
Elwerfalli AM, et al. New Generation of Orally Disintegrating Tablets for Sustained Drug Release: a Propitious Outlook. Curr Drug Deliv. 2015;12(6):652-67. PubMed PMID: 25760951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New Generation of Orally Disintegrating Tablets for Sustained Drug Release: A Propitious Outlook. AU - Elwerfalli,Arwa Matoug, AU - Ghanchi,Zabir, AU - Rashid,Fatema, AU - Alany,Raid G, AU - ElShaer,Amr, PY - 2014/10/29/received PY - 2015/01/22/revised PY - 2015/02/27/accepted PY - 2015/3/12/entrez PY - 2015/3/12/pubmed PY - 2016/9/27/medline SP - 652 EP - 67 JF - Current drug delivery JO - Curr Drug Deliv VL - 12 IS - 6 N2 - Orally disintegrating tablets (ODTs) or orodispersible tablets are solid dosage forms that disintegrate within 3 minutes in the mouth into a paste that can be easily swallowed. ODTs have improved over the past years, in an attempt to produce a safe and efficient substitute to the conventional oral dosage forms, particularly for dysphagia patients. Since its introduction in the market in the 1980s, ODTs expanded rapidly and achieved revenues over $3 billion in 2006 and sustaining 20% annual growth. It is therefore evident that ODTs carry good commercial value, however there is potential for improvement. Current sustained-release technologies may be exploited and incorporated into an ODT to provide greater therapeutic value by reducing the need for multiple daily dosing regimens and improving patient adherence. A number of technologies such as polymer coated nanoparticles, stimuli-responsive polymers and ion-exchange resins have emerged to produce robust, sustained release orally disintegrating tablets (SR-ODT). The purpose of this review is to highlight these various approaches and techniques and how they have been utilised in an ODT formulation to extend differentiated line, market exclusivity and patent life. The review also explores future perspective and the potential challenges that SR-ODTs will face. SN - 1875-5704 UR - https://www.unboundmedicine.com/medline/citation/25760951/New_Generation_of_Orally_Disintegrating_Tablets_for_Sustained_Drug_Release:_A_Propitious_Outlook_ L2 - http://www.eurekaselect.com/129358/article DB - PRIME DP - Unbound Medicine ER -