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Pregnancy and perinatal outcomes in women with polycystic ovary syndrome and twin births: a population-based cohort study.
BJOG. 2015 Sep; 122(10):1295-302.BJOG

Abstract

OBJECTIVE

To investigate pregnancy and perinatal outcomes in twin births among women with and without polycystic ovary syndrome (PCOS) diagnosis.

DESIGN

Population-based cohort study.

SETTING

Sweden.

POPULATION

We identified 20,965 women with twin births between 1995 and 2009 of whom 226 had a PCOS diagnosis through linkage between the Swedish Medical Birth Register and the Swedish National Patient Register.

METHODS

Calculating risk ratios (RR) with 95% confidence intervals (CI) using a log-binomial regression model and hazard ratios (HR) with 95% CI for preterm birth.

MAIN OUTCOME MEASURES

Preterm birth, low birthweight, caesarean section, pre-eclampsia, Apgar score <7 at 5 minutes and perinatal mortality.

RESULTS

PCOS diagnosis in twin pregnancy was associated with increased risk of preterm delivery (51% versus 43%, RR 1.18 [95% CI 1.03-1.37]), particularly spontaneous preterm delivery (37% versus 28%; RR 1.30 [95% CI 1.09-1.55]) and very preterm birth (<32 weeks) (14% versus 8%, RR 1.62 [95% CI 1.10-2.37]). Twins of PCOS mothers had more often low birthweight (48% versus 39%, adjusted RR 1.40 [95% CI 1.09-1.80]). This difference disappeared when adjusting for gestational age. No risk difference was found for caesarean section, pre-eclampsia, low 5-minute Apgar score or perinatal mortality.

CONCLUSIONS

The risk of preterm delivery in twin pregnancies is increased by having a PCOS diagnosis. This should be considered in risk estimation and antenatal follow-up of twin pregnancies.

Authors+Show Affiliations

Institute of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway. Department of Obstetrics and Gynaecology, St Olavs Hospital, Trondheim, Norway.Department of Medicine, Solna, Clinical Epidemiology Unit, Karolinska Institute, Stockholm, Sweden. Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.Department of Medicine, Solna, Clinical Epidemiology Unit, Karolinska Institute, Stockholm, Sweden.Department of Medicine, Solna, Clinical Epidemiology Unit, Karolinska Institute, Stockholm, Sweden. Division of Obstetrics and Gynaecology, Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.Department of Medicine, Solna, Clinical Epidemiology Unit, Karolinska Institute, Stockholm, Sweden. Division of Obstetrics and Gynaecology, Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.Institute of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway. Department of Obstetrics and Gynaecology, St Olavs Hospital, Trondheim, Norway.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25761516

Citation

Løvvik, T S., et al. "Pregnancy and Perinatal Outcomes in Women With Polycystic Ovary Syndrome and Twin Births: a Population-based Cohort Study." BJOG : an International Journal of Obstetrics and Gynaecology, vol. 122, no. 10, 2015, pp. 1295-302.
Løvvik TS, Wikström AK, Neovius M, et al. Pregnancy and perinatal outcomes in women with polycystic ovary syndrome and twin births: a population-based cohort study. BJOG. 2015;122(10):1295-302.
Løvvik, T. S., Wikström, A. K., Neovius, M., Stephansson, O., Roos, N., & Vanky, E. (2015). Pregnancy and perinatal outcomes in women with polycystic ovary syndrome and twin births: a population-based cohort study. BJOG : an International Journal of Obstetrics and Gynaecology, 122(10), 1295-302. https://doi.org/10.1111/1471-0528.13339
Løvvik TS, et al. Pregnancy and Perinatal Outcomes in Women With Polycystic Ovary Syndrome and Twin Births: a Population-based Cohort Study. BJOG. 2015;122(10):1295-302. PubMed PMID: 25761516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pregnancy and perinatal outcomes in women with polycystic ovary syndrome and twin births: a population-based cohort study. AU - Løvvik,T S, AU - Wikström,A-K, AU - Neovius,M, AU - Stephansson,O, AU - Roos,N, AU - Vanky,E, Y1 - 2015/03/11/ PY - 2015/01/17/accepted PY - 2015/3/13/entrez PY - 2015/3/13/pubmed PY - 2015/11/17/medline KW - Cohort study KW - polycystic ovary syndrome KW - pregnancy outcome KW - preterm birth KW - twins SP - 1295 EP - 302 JF - BJOG : an international journal of obstetrics and gynaecology JO - BJOG VL - 122 IS - 10 N2 - OBJECTIVE: To investigate pregnancy and perinatal outcomes in twin births among women with and without polycystic ovary syndrome (PCOS) diagnosis. DESIGN: Population-based cohort study. SETTING: Sweden. POPULATION: We identified 20,965 women with twin births between 1995 and 2009 of whom 226 had a PCOS diagnosis through linkage between the Swedish Medical Birth Register and the Swedish National Patient Register. METHODS: Calculating risk ratios (RR) with 95% confidence intervals (CI) using a log-binomial regression model and hazard ratios (HR) with 95% CI for preterm birth. MAIN OUTCOME MEASURES: Preterm birth, low birthweight, caesarean section, pre-eclampsia, Apgar score <7 at 5 minutes and perinatal mortality. RESULTS: PCOS diagnosis in twin pregnancy was associated with increased risk of preterm delivery (51% versus 43%, RR 1.18 [95% CI 1.03-1.37]), particularly spontaneous preterm delivery (37% versus 28%; RR 1.30 [95% CI 1.09-1.55]) and very preterm birth (<32 weeks) (14% versus 8%, RR 1.62 [95% CI 1.10-2.37]). Twins of PCOS mothers had more often low birthweight (48% versus 39%, adjusted RR 1.40 [95% CI 1.09-1.80]). This difference disappeared when adjusting for gestational age. No risk difference was found for caesarean section, pre-eclampsia, low 5-minute Apgar score or perinatal mortality. CONCLUSIONS: The risk of preterm delivery in twin pregnancies is increased by having a PCOS diagnosis. This should be considered in risk estimation and antenatal follow-up of twin pregnancies. SN - 1471-0528 UR - https://www.unboundmedicine.com/medline/citation/25761516/Pregnancy_and_perinatal_outcomes_in_women_with_polycystic_ovary_syndrome_and_twin_births:_a_population_based_cohort_study_ L2 - https://doi.org/10.1111/1471-0528.13339 DB - PRIME DP - Unbound Medicine ER -