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A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat.
Auton Autacoid Pharmacol. 2015 Apr; 34(3-4):35-40.AA

Abstract

In the rat, a high-fat (HF) plus fructose (F) diet produces cardiovascular and metabolic alterations that resemble human metabolic syndrome. Prostanoids (PR), cyclo-oxygenase-derived arachidonic acid metabolites, have vasoactive properties and mediate inflammation. The aim of this study was to analyse the effect of a HF+F diet on blood pressure (BP), metabolic parameters and mesenteric vascular bed PR production in male Sprague-Dawley rats. Four groups were studied over 9 weeks (n = 6 each): control (C), standard diet (SD) and tap water to drink; F+SD and 10% w/v F solution to drink; HF 50% (w/w) bovine fat added to SD and tap water; and HFF, both treatments. PR were determined by HPLC. Blood pressure was elevated in all experimental groups. Triglyceridaemia, insulinaemia and HOMA-IR were increased in the F and HF groups. HF+F animals showed elevated glycaemia, insulinaemia, HOMA-IR and triglyceridaemia. F decreased the vasodilator prostanoids PGI2 and PGE2 in the mesenteric vascular bed. Body weight was not significantly altered. In HFF, production of PGE2 , PGF2 alpha and TXB2 was elevated. The increased BP in HF and HFF could be partly attributed to the imbalance in vascular PR production towards vasoconstrictors. On the other hand, this dietary modification could induce inflammation, which would explain the elevation of PGE2 . In the F group, hypertension could be related to decreased vasodilator PRs. The simultaneous administration of HF and F in the rat produces deleterious effects greater than observed when treatments are applied separately.

Authors+Show Affiliations

CONICET, Cátedra Anatomía Histología and INFIBIOC, Junin 956, Buenos Aires, Argentina; Fac Farm y Bioq UBA, Cátedra Anatomía Histología and INFIBIOC, Junin 956, Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25761783

Citation

Peredo, H A., et al. "A High-fat Plus Fructose Diet Produces a Vascular Prostanoid Alterations in the Rat." Autonomic & Autacoid Pharmacology, vol. 34, no. 3-4, 2015, pp. 35-40.
Peredo HA, Lee H, Donoso AS, et al. A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat. Auton Autacoid Pharmacol. 2015;34(3-4):35-40.
Peredo, H. A., Lee, H., Donoso, A. S., Andrade, V., Sánchez Eluchans, N., & Puyó, A. M. (2015). A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat. Autonomic & Autacoid Pharmacology, 34(3-4), 35-40. https://doi.org/10.1111/aap.12021
Peredo HA, et al. A High-fat Plus Fructose Diet Produces a Vascular Prostanoid Alterations in the Rat. Auton Autacoid Pharmacol. 2015;34(3-4):35-40. PubMed PMID: 25761783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A high-fat plus fructose diet produces a vascular prostanoid alterations in the rat. AU - Peredo,H A, AU - Lee,H, AU - Donoso,A S, AU - Andrade,V, AU - Sánchez Eluchans,N, AU - Puyó,A M, Y1 - 2015/03/12/ PY - 2014/10/28/received PY - 2015/01/14/revised PY - 2015/01/21/accepted PY - 2015/3/13/entrez PY - 2015/3/13/pubmed PY - 2016/2/27/medline KW - fructose KW - high fat KW - hypertension KW - metabolic syndrome KW - prostanoids SP - 35 EP - 40 JF - Autonomic & autacoid pharmacology JO - Auton Autacoid Pharmacol VL - 34 IS - 3-4 N2 - In the rat, a high-fat (HF) plus fructose (F) diet produces cardiovascular and metabolic alterations that resemble human metabolic syndrome. Prostanoids (PR), cyclo-oxygenase-derived arachidonic acid metabolites, have vasoactive properties and mediate inflammation. The aim of this study was to analyse the effect of a HF+F diet on blood pressure (BP), metabolic parameters and mesenteric vascular bed PR production in male Sprague-Dawley rats. Four groups were studied over 9 weeks (n = 6 each): control (C), standard diet (SD) and tap water to drink; F+SD and 10% w/v F solution to drink; HF 50% (w/w) bovine fat added to SD and tap water; and HFF, both treatments. PR were determined by HPLC. Blood pressure was elevated in all experimental groups. Triglyceridaemia, insulinaemia and HOMA-IR were increased in the F and HF groups. HF+F animals showed elevated glycaemia, insulinaemia, HOMA-IR and triglyceridaemia. F decreased the vasodilator prostanoids PGI2 and PGE2 in the mesenteric vascular bed. Body weight was not significantly altered. In HFF, production of PGE2 , PGF2 alpha and TXB2 was elevated. The increased BP in HF and HFF could be partly attributed to the imbalance in vascular PR production towards vasoconstrictors. On the other hand, this dietary modification could induce inflammation, which would explain the elevation of PGE2 . In the F group, hypertension could be related to decreased vasodilator PRs. The simultaneous administration of HF and F in the rat produces deleterious effects greater than observed when treatments are applied separately. SN - 1474-8673 UR - https://www.unboundmedicine.com/medline/citation/25761783/A_high_fat_plus_fructose_diet_produces_a_vascular_prostanoid_alterations_in_the_rat_ L2 - https://doi.org/10.1111/aap.12021 DB - PRIME DP - Unbound Medicine ER -