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    Treatment with some anti-inflammatory drugs reduces germ tube formation in Candida albicans strains.

    Abstract

    Candida albicans is an opportunistic dimorphic fungus that inhabits various host mucosal sites. It can cause both superficial and serious systemic disease. Conversion from the yeast to the hyphal form has been associated with increased virulence and mucosal invasiveness. The aim of this study was to investigate the effect of sodium diclofenac and aspirin on germs tube formation of different Candida albicans strains. Prostaglandins may play an important role in fungal colonization. Nonsteroidal anti-inflammatory drugs are inhibitors of the cyclooxygenase isoenzymes. These drugs specifically block the biosynthesis of mammalian prostaglandins by inhibiting one or both of cyclooxygenase isoenzymes. In tests for germ tube formation sodium diclofenac reduced the filamentation to the 12.5%- 5.1%. In the presence of aspirin the filamentation was reduced up to 85-45% depending on the tested strain. Our results suggest that cyclooxygenase-depending synthesis of fungal prostaglandins is important for morphogenesis and fungal virulence. Inhibitors of cyclooxygenase isoensymes (aspirin and diclofenac) are effective in decreasing germ tube formation of Candida albicans.

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    Authors+Show Affiliations

    Rusu E
    ,

    Preclinical Department Faculty of Medicine Titu Maiorescu University Bucharest Romania Preclinical Department, Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania.

    Radu-Popescu M
    ,

    Department of Microbiology Faculty of Pharmacy University of Medicine and Pharmacy Carol Davila Bucharest Romania Department of Microbiology, Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.

    Pelinescu D
    ,

    Center for Research, Training & Consulting in Microbiology, Genetics and Biotechnology, Faculty of Biology University of Bucharest Romania Center for Research, Training & Consulting in Microbiology, Genetics and Biotechnology, Faculty of Biology, University of Bucharest, Romania.

    Vassu T

    Center for Research, Training & Consulting in Microbiology, Genetics and Biotechnology, Faculty of Biology University of Bucharest Romania Center for Research, Training & Consulting in Microbiology, Genetics and Biotechnology, Faculty of Biology, University of Bucharest, Romania.

    Source

    MeSH

    Anti-Inflammatory Agents
    Antifungal Agents
    Aspirin
    Candida albicans
    Diclofenac
    Hyphae

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    25763044

    Citation

    TY - JOUR T1 - Treatment with some anti-inflammatory drugs reduces germ tube formation in Candida albicans strains. AU - Rusu,Elena, AU - Radu-Popescu,Manuela, AU - Pelinescu,Diana, AU - Vassu,Tatiana, Y1 - 2015/03/04/ PY - 2013/06/11/received PY - 2014/04/17/accepted PY - 2015/3/13/entrez PY - 2014/1/1/pubmed PY - 2015/10/16/medline KW - Candida KW - aspirin KW - diclofenac KW - germ tube SP - 1379 EP - 83 JF - Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] JO - Braz. J. Microbiol. VL - 45 IS - 4 N2 - Candida albicans is an opportunistic dimorphic fungus that inhabits various host mucosal sites. It can cause both superficial and serious systemic disease. Conversion from the yeast to the hyphal form has been associated with increased virulence and mucosal invasiveness. The aim of this study was to investigate the effect of sodium diclofenac and aspirin on germs tube formation of different Candida albicans strains. Prostaglandins may play an important role in fungal colonization. Nonsteroidal anti-inflammatory drugs are inhibitors of the cyclooxygenase isoenzymes. These drugs specifically block the biosynthesis of mammalian prostaglandins by inhibiting one or both of cyclooxygenase isoenzymes. In tests for germ tube formation sodium diclofenac reduced the filamentation to the 12.5%- 5.1%. In the presence of aspirin the filamentation was reduced up to 85-45% depending on the tested strain. Our results suggest that cyclooxygenase-depending synthesis of fungal prostaglandins is important for morphogenesis and fungal virulence. Inhibitors of cyclooxygenase isoensymes (aspirin and diclofenac) are effective in decreasing germ tube formation of Candida albicans. SN - 1678-4405 UR - https://www.unboundmedicine.com/medline/citation/25763044/Treatment_with_some_anti_inflammatory_drugs_reduces_germ_tube_formation_in_Candida_albicans_strains_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25763044/ ER -