Tags

Type your tag names separated by a space and hit enter

Eicosapentaenoic acid in cancer improves body composition and modulates metabolism.
Nutrition. 2015 Apr; 31(4):549-55.N

Abstract

OBJECTIVES

The objective of this review article is to present the most recent intervention studies with EPA on nutritional outcomes in cancer patients, e.g. nutritional status, weight & lean body mass.

METHODS

For this purpose a PubMed(®) and MedLine(®) search of the published literature up to and including January 2014 that contained the keywords: cancer, sarcopenia, EPA, ω-3 fatty acids, weight, intervention trial, muscle mass was conducted. The collected data was summarized and written in text format and in tables that contained: study design, patient' population, sample size, statistical significance and results of the intervention. The paper will cover malignancy, body composition, intervention with EPA, physiological mechanisms of action of EPA, effect of EPA on weight and body composition, future research.

RESULTS

In cancer patients deterioration of muscle mass can be present regardless of body weight or Body Mass Index (BMI). Thus, sarcopenia in cancer patients with excessive fat mass (FM), entitled sarcopenic obesity, has gained greater relevance in clinical practice; it can negatively influence patients' functional status, tolerance to treatments & disease prognosis. The search for an effective nutritional intervention that improves body composition (preservation of muscle mass and muscle quality) is of utmost importance for clinicians and patients. The improvement of muscle quality is an even more recent area of interest because it has probable implications in patients' prognosis. Eicosapentaenoic acid (EPA) has been identified as a promising nutrient with the wide clinical benefits. Several mechanisms have been proposed to explain EPA potential benefits on body composition: inhibition of catabolic stimuli by modulating pro-inflammatory cytokines production and enhancing insulin sensitivity that induces protein synthesis; also, EPA may attenuate deterioration of nutritional status resulting from antineoplastic therapies by improving calorie and protein intake as well.

CONCLUSIONS

Indeed, cancer-related sarcopenia/cachexia is a multifactorial syndrome characterized by inflammation, anorexia, weight loss, and muscle/adipose tissue loss mediated by proinflammatory cytokines, e.g. TNF-α and IL-6, resulting in increased chemotherapy toxicity, costs, morbidity and mortality. With this review we found that EPA can reduce inflammation and has the potential to modulate nutritional status/body composition. In view of the modest survival benefits of chemotherapy/radiotherapy in some cancers, important issues for physicians are to optimize well-being, Quality of Life via nutritional status and adequate body composition. Thus, improvement in nutritional status is a central outcome.

Authors+Show Affiliations

Laboratório de Nutrição da Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.Laboratório de Nutrição da Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.Laboratório de Nutrição da Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal. Electronic address: p.ravasco@medicina.ulisboa.pt.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25770317

Citation

Pappalardo, Giulia, et al. "Eicosapentaenoic Acid in Cancer Improves Body Composition and Modulates Metabolism." Nutrition (Burbank, Los Angeles County, Calif.), vol. 31, no. 4, 2015, pp. 549-55.
Pappalardo G, Almeida A, Ravasco P. Eicosapentaenoic acid in cancer improves body composition and modulates metabolism. Nutrition. 2015;31(4):549-55.
Pappalardo, G., Almeida, A., & Ravasco, P. (2015). Eicosapentaenoic acid in cancer improves body composition and modulates metabolism. Nutrition (Burbank, Los Angeles County, Calif.), 31(4), 549-55. https://doi.org/10.1016/j.nut.2014.12.002
Pappalardo G, Almeida A, Ravasco P. Eicosapentaenoic Acid in Cancer Improves Body Composition and Modulates Metabolism. Nutrition. 2015;31(4):549-55. PubMed PMID: 25770317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eicosapentaenoic acid in cancer improves body composition and modulates metabolism. AU - Pappalardo,Giulia, AU - Almeida,Ana, AU - Ravasco,Paula, Y1 - 2014/12/12/ PY - 2014/08/08/received PY - 2014/11/24/revised PY - 2014/12/02/accepted PY - 2015/3/16/entrez PY - 2015/3/17/pubmed PY - 2015/12/15/medline KW - Body composition KW - Cancer KW - Eicosapentanoic acid KW - Muscle mass KW - Nutrition SP - 549 EP - 55 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 31 IS - 4 N2 - OBJECTIVES: The objective of this review article is to present the most recent intervention studies with EPA on nutritional outcomes in cancer patients, e.g. nutritional status, weight & lean body mass. METHODS: For this purpose a PubMed(®) and MedLine(®) search of the published literature up to and including January 2014 that contained the keywords: cancer, sarcopenia, EPA, ω-3 fatty acids, weight, intervention trial, muscle mass was conducted. The collected data was summarized and written in text format and in tables that contained: study design, patient' population, sample size, statistical significance and results of the intervention. The paper will cover malignancy, body composition, intervention with EPA, physiological mechanisms of action of EPA, effect of EPA on weight and body composition, future research. RESULTS: In cancer patients deterioration of muscle mass can be present regardless of body weight or Body Mass Index (BMI). Thus, sarcopenia in cancer patients with excessive fat mass (FM), entitled sarcopenic obesity, has gained greater relevance in clinical practice; it can negatively influence patients' functional status, tolerance to treatments & disease prognosis. The search for an effective nutritional intervention that improves body composition (preservation of muscle mass and muscle quality) is of utmost importance for clinicians and patients. The improvement of muscle quality is an even more recent area of interest because it has probable implications in patients' prognosis. Eicosapentaenoic acid (EPA) has been identified as a promising nutrient with the wide clinical benefits. Several mechanisms have been proposed to explain EPA potential benefits on body composition: inhibition of catabolic stimuli by modulating pro-inflammatory cytokines production and enhancing insulin sensitivity that induces protein synthesis; also, EPA may attenuate deterioration of nutritional status resulting from antineoplastic therapies by improving calorie and protein intake as well. CONCLUSIONS: Indeed, cancer-related sarcopenia/cachexia is a multifactorial syndrome characterized by inflammation, anorexia, weight loss, and muscle/adipose tissue loss mediated by proinflammatory cytokines, e.g. TNF-α and IL-6, resulting in increased chemotherapy toxicity, costs, morbidity and mortality. With this review we found that EPA can reduce inflammation and has the potential to modulate nutritional status/body composition. In view of the modest survival benefits of chemotherapy/radiotherapy in some cancers, important issues for physicians are to optimize well-being, Quality of Life via nutritional status and adequate body composition. Thus, improvement in nutritional status is a central outcome. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/25770317/Eicosapentaenoic_acid_in_cancer_improves_body_composition_and_modulates_metabolism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(14)00501-2 DB - PRIME DP - Unbound Medicine ER -