Tags

Type your tag names separated by a space and hit enter

Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis.
J Am Acad Dermatol 2015; 72(4):606-16.e4JA

Abstract

BACKGROUND

Previous studies found conflicting results about whether atopic dermatitis (AD) is associated with overweight/obesity.

OBJECTIVE

We sought to examine the relationship between AD and overweight/obesity by performing a systematic review and metaanalysis.

METHODS

Observational studies of the relationship between AD and overweight/obesity were selected from PubMed, Embase, and the Cochrane Library. The quality of evidence was assessed using the Newcastle-Ottawa Scale. Fixed and random effects metaanalyses were performed to estimate pooled odds ratios (ORs). Sensitivity analyses were performed that compared results by location of study, study quality, and between studies in children and adults.

RESULTS

In total, 30 studies were included for review. Patients who were overweight (Cochrane-Mantel-Haenszel [CMH] OR, 1.27 [95% confidence interval {CI}: 1.19-1.36]; random effects OR, 1.23 [95% CI: 1.11-1.41]), obese (CMH OR, 1.68 [95% CI: 1.54-1.84]; random effects OR, 1.47 [95% CI: 1.21-1.79]), or overweight/obese (CMH OR, 1.42 [95% CI: 1.34-1.50]; random effects OR, 1.31 [95% CI: 1.16-1.48]) had higher odds of AD than normal weight patients. In sensitivity analyses, children who were overweight (random effects OR, 1.24 [95% CI: 1.08-1.43]), obese (random effects OR, 1.44 [95% CI: 1.12-1.86]), or overweight/obese (random effects OR, 1.32 [95% CI: 1.15-1.51]) and adults who were obese (random effects OR, 1.56 [95% CI: 1.24-1.95]) or overweight/obese (random effects OR, 1.29 [95% CI: 1.05-1.59]) had higher odds of AD. The association remained significant in North America and Asia but not Europe.

LIMITATIONS

Most studies were cross-sectional.

CONCLUSIONS

Overweight/obesity in North America and Asia is associated with an increased prevalence of AD.

Authors+Show Affiliations

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address: JonathanISilverberg@gmail.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

25773409

Citation

Zhang, April, and Jonathan I. Silverberg. "Association of Atopic Dermatitis With Being Overweight and Obese: a Systematic Review and Metaanalysis." Journal of the American Academy of Dermatology, vol. 72, no. 4, 2015, pp. 606-16.e4.
Zhang A, Silverberg JI. Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis. J Am Acad Dermatol. 2015;72(4):606-16.e4.
Zhang, A., & Silverberg, J. I. (2015). Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis. Journal of the American Academy of Dermatology, 72(4), pp. 606-16.e4. doi:10.1016/j.jaad.2014.12.013.
Zhang A, Silverberg JI. Association of Atopic Dermatitis With Being Overweight and Obese: a Systematic Review and Metaanalysis. J Am Acad Dermatol. 2015;72(4):606-16.e4. PubMed PMID: 25773409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis. AU - Zhang,April, AU - Silverberg,Jonathan I, PY - 2014/10/06/received PY - 2014/11/30/revised PY - 2014/12/06/accepted PY - 2015/3/17/entrez PY - 2015/3/17/pubmed PY - 2015/5/20/medline KW - adiposity KW - atopic dermatitis KW - body mass index KW - eczema KW - metaanalysis KW - obesity KW - overweight KW - prevalence SP - 606 EP - 16.e4 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 72 IS - 4 N2 - BACKGROUND: Previous studies found conflicting results about whether atopic dermatitis (AD) is associated with overweight/obesity. OBJECTIVE: We sought to examine the relationship between AD and overweight/obesity by performing a systematic review and metaanalysis. METHODS: Observational studies of the relationship between AD and overweight/obesity were selected from PubMed, Embase, and the Cochrane Library. The quality of evidence was assessed using the Newcastle-Ottawa Scale. Fixed and random effects metaanalyses were performed to estimate pooled odds ratios (ORs). Sensitivity analyses were performed that compared results by location of study, study quality, and between studies in children and adults. RESULTS: In total, 30 studies were included for review. Patients who were overweight (Cochrane-Mantel-Haenszel [CMH] OR, 1.27 [95% confidence interval {CI}: 1.19-1.36]; random effects OR, 1.23 [95% CI: 1.11-1.41]), obese (CMH OR, 1.68 [95% CI: 1.54-1.84]; random effects OR, 1.47 [95% CI: 1.21-1.79]), or overweight/obese (CMH OR, 1.42 [95% CI: 1.34-1.50]; random effects OR, 1.31 [95% CI: 1.16-1.48]) had higher odds of AD than normal weight patients. In sensitivity analyses, children who were overweight (random effects OR, 1.24 [95% CI: 1.08-1.43]), obese (random effects OR, 1.44 [95% CI: 1.12-1.86]), or overweight/obese (random effects OR, 1.32 [95% CI: 1.15-1.51]) and adults who were obese (random effects OR, 1.56 [95% CI: 1.24-1.95]) or overweight/obese (random effects OR, 1.29 [95% CI: 1.05-1.59]) had higher odds of AD. The association remained significant in North America and Asia but not Europe. LIMITATIONS: Most studies were cross-sectional. CONCLUSIONS: Overweight/obesity in North America and Asia is associated with an increased prevalence of AD. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/25773409/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(14)02273-7 DB - PRIME DP - Unbound Medicine ER -