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Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis.

Abstract

BACKGROUND

Previous studies found conflicting results about whether atopic dermatitis (AD) is associated with overweight/obesity.

OBJECTIVE

We sought to examine the relationship between AD and overweight/obesity by performing a systematic review and metaanalysis.

METHODS

Observational studies of the relationship between AD and overweight/obesity were selected from PubMed, Embase, and the Cochrane Library. The quality of evidence was assessed using the Newcastle-Ottawa Scale. Fixed and random effects metaanalyses were performed to estimate pooled odds ratios (ORs). Sensitivity analyses were performed that compared results by location of study, study quality, and between studies in children and adults.

RESULTS

In total, 30 studies were included for review. Patients who were overweight (Cochrane-Mantel-Haenszel [CMH] OR, 1.27 [95% confidence interval {CI}: 1.19-1.36]; random effects OR, 1.23 [95% CI: 1.11-1.41]), obese (CMH OR, 1.68 [95% CI: 1.54-1.84]; random effects OR, 1.47 [95% CI: 1.21-1.79]), or overweight/obese (CMH OR, 1.42 [95% CI: 1.34-1.50]; random effects OR, 1.31 [95% CI: 1.16-1.48]) had higher odds of AD than normal weight patients. In sensitivity analyses, children who were overweight (random effects OR, 1.24 [95% CI: 1.08-1.43]), obese (random effects OR, 1.44 [95% CI: 1.12-1.86]), or overweight/obese (random effects OR, 1.32 [95% CI: 1.15-1.51]) and adults who were obese (random effects OR, 1.56 [95% CI: 1.24-1.95]) or overweight/obese (random effects OR, 1.29 [95% CI: 1.05-1.59]) had higher odds of AD. The association remained significant in North America and Asia but not Europe.

LIMITATIONS

Most studies were cross-sectional.

CONCLUSIONS

Overweight/obesity in North America and Asia is associated with an increased prevalence of AD.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address: JonathanISilverberg@gmail.com.

    Source

    MeSH

    Adult
    Age Factors
    Body Mass Index
    Child
    Cohort Studies
    Continental Population Groups
    Cross-Sectional Studies
    Dermatitis, Atopic
    Eczema
    Female
    Global Health
    Humans
    Male
    Obesity
    Observational Studies as Topic
    Odds Ratio
    Overweight
    Publication Bias

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    25773409

    Citation

    Zhang, April, and Jonathan I. Silverberg. "Association of Atopic Dermatitis With Being Overweight and Obese: a Systematic Review and Metaanalysis." Journal of the American Academy of Dermatology, vol. 72, no. 4, 2015, pp. 606-16.e4.
    Zhang A, Silverberg JI. Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis. J Am Acad Dermatol. 2015;72(4):606-16.e4.
    Zhang, A., & Silverberg, J. I. (2015). Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis. Journal of the American Academy of Dermatology, 72(4), pp. 606-16.e4. doi:10.1016/j.jaad.2014.12.013.
    Zhang A, Silverberg JI. Association of Atopic Dermatitis With Being Overweight and Obese: a Systematic Review and Metaanalysis. J Am Acad Dermatol. 2015;72(4):606-16.e4. PubMed PMID: 25773409.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis. AU - Zhang,April, AU - Silverberg,Jonathan I, PY - 2014/10/06/received PY - 2014/11/30/revised PY - 2014/12/06/accepted PY - 2015/3/17/entrez PY - 2015/3/17/pubmed PY - 2015/5/20/medline KW - adiposity KW - atopic dermatitis KW - body mass index KW - eczema KW - metaanalysis KW - obesity KW - overweight KW - prevalence SP - 606 EP - 16.e4 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 72 IS - 4 N2 - BACKGROUND: Previous studies found conflicting results about whether atopic dermatitis (AD) is associated with overweight/obesity. OBJECTIVE: We sought to examine the relationship between AD and overweight/obesity by performing a systematic review and metaanalysis. METHODS: Observational studies of the relationship between AD and overweight/obesity were selected from PubMed, Embase, and the Cochrane Library. The quality of evidence was assessed using the Newcastle-Ottawa Scale. Fixed and random effects metaanalyses were performed to estimate pooled odds ratios (ORs). Sensitivity analyses were performed that compared results by location of study, study quality, and between studies in children and adults. RESULTS: In total, 30 studies were included for review. Patients who were overweight (Cochrane-Mantel-Haenszel [CMH] OR, 1.27 [95% confidence interval {CI}: 1.19-1.36]; random effects OR, 1.23 [95% CI: 1.11-1.41]), obese (CMH OR, 1.68 [95% CI: 1.54-1.84]; random effects OR, 1.47 [95% CI: 1.21-1.79]), or overweight/obese (CMH OR, 1.42 [95% CI: 1.34-1.50]; random effects OR, 1.31 [95% CI: 1.16-1.48]) had higher odds of AD than normal weight patients. In sensitivity analyses, children who were overweight (random effects OR, 1.24 [95% CI: 1.08-1.43]), obese (random effects OR, 1.44 [95% CI: 1.12-1.86]), or overweight/obese (random effects OR, 1.32 [95% CI: 1.15-1.51]) and adults who were obese (random effects OR, 1.56 [95% CI: 1.24-1.95]) or overweight/obese (random effects OR, 1.29 [95% CI: 1.05-1.59]) had higher odds of AD. The association remained significant in North America and Asia but not Europe. LIMITATIONS: Most studies were cross-sectional. CONCLUSIONS: Overweight/obesity in North America and Asia is associated with an increased prevalence of AD. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/25773409/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(14)02273-7 DB - PRIME DP - Unbound Medicine ER -