Tags

Type your tag names separated by a space and hit enter

7, 8-dihydroxycoumarin improves neurological function in a mouse model of sciatic nerve injury.
Neural Regen Res 2012; 7(6):445-50NR

Abstract

In the present study, a mouse model of sciatic nerve injury was treated with intraperitoneal injection of 7, 8-dihydroxycoumarin (10, 5, or 2.5 mg/kg per day). Western blot and real-time PCR results showed that growth associated protein 43 expression was significantly increased in the L4-6 segments of the spinal cord. The amplitude and velocity of motor nerve conduction in the sciatic nerve were significantly increased in model mice. In addition, the appearance of the myelin sheath in the injured sciatic nerve was regular, with an even thickness and clear outline, and the surrounding fibroplasia was not obvious. Our results indicate that 7, 8-dihydroxycoumarin can promote the repair of injured nerve by upregulating growth associated protein 43 expression in the corresponding spinal cord segments of mice with sciatic nerve injury.

Authors+Show Affiliations

Department of Vascular Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25774187

Citation

Du, Jianshi, et al. "7, 8-dihydroxycoumarin Improves Neurological Function in a Mouse Model of Sciatic Nerve Injury." Neural Regeneration Research, vol. 7, no. 6, 2012, pp. 445-50.
Du J, Zhao Q, Zhang Y, et al. 7, 8-dihydroxycoumarin improves neurological function in a mouse model of sciatic nerve injury. Neural Regen Res. 2012;7(6):445-50.
Du, J., Zhao, Q., Zhang, Y., Wang, Y., & Ma, M. (2012). 7, 8-dihydroxycoumarin improves neurological function in a mouse model of sciatic nerve injury. Neural Regeneration Research, 7(6), pp. 445-50. doi:10.3969/j.issn.1673-5374.2012.06.007.
Du J, et al. 7, 8-dihydroxycoumarin Improves Neurological Function in a Mouse Model of Sciatic Nerve Injury. Neural Regen Res. 2012 Feb 25;7(6):445-50. PubMed PMID: 25774187.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 7, 8-dihydroxycoumarin improves neurological function in a mouse model of sciatic nerve injury. AU - Du,Jianshi, AU - Zhao,Qing, AU - Zhang,Yingli, AU - Wang,Yu, AU - Ma,Ming, PY - 2011/09/24/received PY - 2011/12/22/accepted PY - 2015/3/17/entrez PY - 2012/2/25/pubmed PY - 2012/2/25/medline KW - 7 KW - 8-dihydroxycoumarin KW - growth associated protein 43 KW - neural regeneration KW - peripheral nerve injury KW - sciatic nerve SP - 445 EP - 50 JF - Neural regeneration research JO - Neural Regen Res VL - 7 IS - 6 N2 - In the present study, a mouse model of sciatic nerve injury was treated with intraperitoneal injection of 7, 8-dihydroxycoumarin (10, 5, or 2.5 mg/kg per day). Western blot and real-time PCR results showed that growth associated protein 43 expression was significantly increased in the L4-6 segments of the spinal cord. The amplitude and velocity of motor nerve conduction in the sciatic nerve were significantly increased in model mice. In addition, the appearance of the myelin sheath in the injured sciatic nerve was regular, with an even thickness and clear outline, and the surrounding fibroplasia was not obvious. Our results indicate that 7, 8-dihydroxycoumarin can promote the repair of injured nerve by upregulating growth associated protein 43 expression in the corresponding spinal cord segments of mice with sciatic nerve injury. SN - 1673-5374 UR - https://www.unboundmedicine.com/medline/citation/25774187/7_8_dihydroxycoumarin_improves_neurological_function_in_a_mouse_model_of_sciatic_nerve_injury_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25774187/ DB - PRIME DP - Unbound Medicine ER -