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Conservative management of preterm premature rupture of membranes beyond 32 weeks' gestation: is it worthwhile?
J Obstet Gynaecol. 2015; 35(6):585-90.JO

Abstract

We aimed to investigate whether conservative management of preterm premature rupture of membranes (PPROM) at 32-34 weeks' gestation improves outcome. In this retrospective analysis of singleton pregnancies, the study group included patients with PPROM at 28-34 weeks' gestation and the control group included patients presented with spontaneous preterm delivery at 28-34 weeks' gestation. Both groups were subdivided according to gestational age - early (28-31 weeks' gestation) versus late (32-34 weeks' gestation). Adverse neonatal outcome included neonatal death, intraventricular haemorrhage grade 3/4, respiratory distress syndrome, periventricular leucomalacia and neonatal sepsis. The study and control groups included 94 and 86 women, respectively. The study group had a lower incidence of adverse neonatal outcome at the earlier weeks (28-31), compared with the control group at the same gestational age. In contrast, at 32-34 weeks' gestation no difference in the risk for adverse neonatal outcome was noticed. Additionally, within the study group, chorioamnionitis rate was significantly higher among those who delivered at 32-34 weeks' gestation (p < 0.01). No advantage for conservative management of PPROM was demonstrated beyond 31 weeks' gestation. Moreover, conservative management of PPROM at 32-34 weeks' gestation may expose both mother and neonate to infectious morbidity.

Authors+Show Affiliations

a The Department of Gynecology.a The Department of Gynecology.a The Department of Gynecology.a The Department of Gynecology.a The Department of Gynecology.a The Department of Gynecology.b Neonatal Intensive Care Unit, Lis Maternity Hospital, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University , Tel Aviv , Israel.a The Department of Gynecology.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25774537

Citation

Tsafrir, Z, et al. "Conservative Management of Preterm Premature Rupture of Membranes Beyond 32 Weeks' Gestation: Is It Worthwhile?" Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology, vol. 35, no. 6, 2015, pp. 585-90.
Tsafrir Z, Margolis G, Cohen Y, et al. Conservative management of preterm premature rupture of membranes beyond 32 weeks' gestation: is it worthwhile? J Obstet Gynaecol. 2015;35(6):585-90.
Tsafrir, Z., Margolis, G., Cohen, Y., Cohen, A., Laskov, I., Levin, I., Mandel, D., & Many, A. (2015). Conservative management of preterm premature rupture of membranes beyond 32 weeks' gestation: is it worthwhile? Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology, 35(6), 585-90. https://doi.org/10.3109/01443615.2014.990432
Tsafrir Z, et al. Conservative Management of Preterm Premature Rupture of Membranes Beyond 32 Weeks' Gestation: Is It Worthwhile. J Obstet Gynaecol. 2015;35(6):585-90. PubMed PMID: 25774537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Conservative management of preterm premature rupture of membranes beyond 32 weeks' gestation: is it worthwhile? AU - Tsafrir,Z, AU - Margolis,G, AU - Cohen,Y, AU - Cohen,A, AU - Laskov,I, AU - Levin,I, AU - Mandel,D, AU - Many,A, Y1 - 2015/03/16/ PY - 2015/3/17/entrez PY - 2015/3/17/pubmed PY - 2016/4/5/medline KW - Conservative management KW - chorioamnionitis KW - outcome KW - preterm premature rupture of membranes SP - 585 EP - 90 JF - Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology JO - J Obstet Gynaecol VL - 35 IS - 6 N2 - We aimed to investigate whether conservative management of preterm premature rupture of membranes (PPROM) at 32-34 weeks' gestation improves outcome. In this retrospective analysis of singleton pregnancies, the study group included patients with PPROM at 28-34 weeks' gestation and the control group included patients presented with spontaneous preterm delivery at 28-34 weeks' gestation. Both groups were subdivided according to gestational age - early (28-31 weeks' gestation) versus late (32-34 weeks' gestation). Adverse neonatal outcome included neonatal death, intraventricular haemorrhage grade 3/4, respiratory distress syndrome, periventricular leucomalacia and neonatal sepsis. The study and control groups included 94 and 86 women, respectively. The study group had a lower incidence of adverse neonatal outcome at the earlier weeks (28-31), compared with the control group at the same gestational age. In contrast, at 32-34 weeks' gestation no difference in the risk for adverse neonatal outcome was noticed. Additionally, within the study group, chorioamnionitis rate was significantly higher among those who delivered at 32-34 weeks' gestation (p < 0.01). No advantage for conservative management of PPROM was demonstrated beyond 31 weeks' gestation. Moreover, conservative management of PPROM at 32-34 weeks' gestation may expose both mother and neonate to infectious morbidity. SN - 1364-6893 UR - https://www.unboundmedicine.com/medline/citation/25774537/Conservative_management_of_preterm_premature_rupture_of_membranes_beyond_32_weeks'_gestation:_is_it_worthwhile L2 - https://www.tandfonline.com/doi/full/10.3109/01443615.2014.990432 DB - PRIME DP - Unbound Medicine ER -