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Antibacterial and antifungal activity of solvent extracts from Plumeria obtusa Linn.
Trop Biomed 2014; 31(4):607-15TB

Abstract

Extracts of Plumeria obtusa are widely used in ethnomedicine and have been investigated for a variety of biological activities; however, the antimicrobial activity of P. obtusa flowers is poorly characterized. In this study, the antimicrobial activities of different solvents (petroleum ether, ethyl acetate, chloroform, isobutanol and ethanol) extracts from flowers of P. obtusa were investigated by a disc diffusion method against Gram-positive bacteria, Gram-negative bacteria and a fungus. All extracts exhibited growth inhibition of all microorganisms at variable degrees as measured by relative zones of inhibition, however, the petroleum ether extract was ineffective against Klebsiella pneumonia and ethyl acetate and isobutanol extracts were ineffective against Pseudomonas aeruginosa. The most susceptible Gram-positive bacterium was Bacillus subtilis while the most resistant Gram-positive bacterium was Staphylococcus aureus. Erwinia carotovora was the most susceptible Gram-negative bacterium while P. aeruginosa was highly resistant among the Gram-negative bacteria. In this study, for the first time, we investigated the antimicrobial activity of several different solvent extracts from flowers of P. obtusa against a broad spectrum of human-pathogenic microorganisms. These compounds warrant further investigation by isolation and structural elucidation with the aim to find novel and affordable bioactive compounds for the treatment of infectious diseases.

Authors+Show Affiliations

Institute of Biotechnology and Genetic Engineering, KPK Agricultural University, Peshawar, 25000 Pakistan.Department of Pharmacy, Division of Pharmacology, University of Malakand, Khyber Pakhtunkhwa, 18550 Pakistan.Institute of Biotechnology and Genetic Engineering, KPK Agricultural University, Peshawar, 25000 Pakistan.Department of Biotechnology, Biology Education Center, Uppsala University, 75124 Sweden.Department of Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, 25000 Pakistan.Bacterial Protein Toxin Research Cluster, Institute of Molecular Biosciences, Mahidol University, Nakornpathom, Salaya, 73170 Thailand.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25776586

Citation

Ali, N, et al. "Antibacterial and Antifungal Activity of Solvent Extracts From Plumeria Obtusa Linn." Tropical Biomedicine, vol. 31, no. 4, 2014, pp. 607-15.
Ali N, Junaid M, Ahmad D, et al. Antibacterial and antifungal activity of solvent extracts from Plumeria obtusa Linn. Trop Biomed. 2014;31(4):607-15.
Ali, N., Junaid, M., Ahmad, D., urRahman, M., Ali, N., & Katzenmeier, G. (2014). Antibacterial and antifungal activity of solvent extracts from Plumeria obtusa Linn. Tropical Biomedicine, 31(4), pp. 607-15.
Ali N, et al. Antibacterial and Antifungal Activity of Solvent Extracts From Plumeria Obtusa Linn. Trop Biomed. 2014;31(4):607-15. PubMed PMID: 25776586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibacterial and antifungal activity of solvent extracts from Plumeria obtusa Linn. AU - Ali,N, AU - Junaid,M, AU - Ahmad,D, AU - urRahman,M, AU - Ali,N, AU - Katzenmeier,G, PY - 2015/3/18/entrez PY - 2015/3/18/pubmed PY - 2015/10/16/medline SP - 607 EP - 15 JF - Tropical biomedicine JO - Trop Biomed VL - 31 IS - 4 N2 - Extracts of Plumeria obtusa are widely used in ethnomedicine and have been investigated for a variety of biological activities; however, the antimicrobial activity of P. obtusa flowers is poorly characterized. In this study, the antimicrobial activities of different solvents (petroleum ether, ethyl acetate, chloroform, isobutanol and ethanol) extracts from flowers of P. obtusa were investigated by a disc diffusion method against Gram-positive bacteria, Gram-negative bacteria and a fungus. All extracts exhibited growth inhibition of all microorganisms at variable degrees as measured by relative zones of inhibition, however, the petroleum ether extract was ineffective against Klebsiella pneumonia and ethyl acetate and isobutanol extracts were ineffective against Pseudomonas aeruginosa. The most susceptible Gram-positive bacterium was Bacillus subtilis while the most resistant Gram-positive bacterium was Staphylococcus aureus. Erwinia carotovora was the most susceptible Gram-negative bacterium while P. aeruginosa was highly resistant among the Gram-negative bacteria. In this study, for the first time, we investigated the antimicrobial activity of several different solvent extracts from flowers of P. obtusa against a broad spectrum of human-pathogenic microorganisms. These compounds warrant further investigation by isolation and structural elucidation with the aim to find novel and affordable bioactive compounds for the treatment of infectious diseases. SN - 0127-5720 UR - https://www.unboundmedicine.com/medline/citation/25776586/Antibacterial_and_antifungal_activity_of_solvent_extracts_from_Plumeria_obtusa_Linn_ L2 - http://www.msptm.org/files/607_-_615_Katzenmeier_G.pdf DB - PRIME DP - Unbound Medicine ER -