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Prospective study of plasma homocysteine level and risk of age-related macular degeneration in women.

Abstract

PURPOSE

Prospective data to examine the association of homocysteine with age-related macular degeneration (AMD) are limited. We examined the prospective relation of plasma homocysteine level and AMD in a large cohort of apparently healthy women.

METHODS

We evaluated the relationship between baseline levels of plasma homocysteine and incident AMD among 27,479 female health professionals aged 40 years or older. Main outcome measures were total AMD, defined as self-report documented by medical record evidence of an initial diagnosis after randomization, and visually significant AMD, defined as confirmed incident AMD with visual acuity 20/30 or worse attributable to this condition.

RESULTS

During an average 10 years of follow-up, a total of 452 cases of AMD, including 182 cases of visually significant AMD, were documented. Women in the highest versus lowest quartile of plasma homocysteine had modestly, but statistically non-significant, increased risks of total AMD (hazard ratio, HR, 1.24, 95% confidence interval, CI, 0.95-1.63; p for trend 0.07) and visually significant AMD (HR 1.41, 95% CI 0.92-2.17; p for trend 0.052) in age- and treatment-adjusted analyses.

CONCLUSIONS

These prospective data from a large cohort of apparently healthy women do not support a strong role for homocysteine in AMD occurrence.

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  • Authors+Show Affiliations

    ,

    Division of Preventive Medicine, Department of Medicine , Brigham and Women's Hospital, Harvard Medical School, Boston, MA , USA .

    , ,

    Source

    Ophthalmic epidemiology 22:2 2015 Apr pg 85-93

    MeSH

    Anti-Inflammatory Agents, Non-Steroidal
    Aspirin
    Cardiovascular Diseases
    Drug Combinations
    Female
    Follow-Up Studies
    Homocysteine
    Humans
    Macular Degeneration
    Middle Aged
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires
    United States
    Visual Acuity
    Vitamin E
    Vitamins
    Women's Health

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25777307

    Citation

    Christen, William G., et al. "Prospective Study of Plasma Homocysteine Level and Risk of Age-related Macular Degeneration in Women." Ophthalmic Epidemiology, vol. 22, no. 2, 2015, pp. 85-93.
    Christen WG, Cook NR, Ridker PM, et al. Prospective study of plasma homocysteine level and risk of age-related macular degeneration in women. Ophthalmic Epidemiol. 2015;22(2):85-93.
    Christen, W. G., Cook, N. R., Ridker, P. M., & Buring, J. E. (2015). Prospective study of plasma homocysteine level and risk of age-related macular degeneration in women. Ophthalmic Epidemiology, 22(2), pp. 85-93. doi:10.3109/09286586.2015.1012272.
    Christen WG, et al. Prospective Study of Plasma Homocysteine Level and Risk of Age-related Macular Degeneration in Women. Ophthalmic Epidemiol. 2015;22(2):85-93. PubMed PMID: 25777307.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prospective study of plasma homocysteine level and risk of age-related macular degeneration in women. AU - Christen,William G, AU - Cook,Nancy R, AU - Ridker,Paul M, AU - Buring,Julie E, PY - 2015/3/18/entrez PY - 2015/3/18/pubmed PY - 2015/9/2/medline KW - Age-related macular degeneration KW - Women's Health Study KW - homocysteine KW - prospective cohort KW - risk factor SP - 85 EP - 93 JF - Ophthalmic epidemiology JO - Ophthalmic Epidemiol VL - 22 IS - 2 N2 - PURPOSE: Prospective data to examine the association of homocysteine with age-related macular degeneration (AMD) are limited. We examined the prospective relation of plasma homocysteine level and AMD in a large cohort of apparently healthy women. METHODS: We evaluated the relationship between baseline levels of plasma homocysteine and incident AMD among 27,479 female health professionals aged 40 years or older. Main outcome measures were total AMD, defined as self-report documented by medical record evidence of an initial diagnosis after randomization, and visually significant AMD, defined as confirmed incident AMD with visual acuity 20/30 or worse attributable to this condition. RESULTS: During an average 10 years of follow-up, a total of 452 cases of AMD, including 182 cases of visually significant AMD, were documented. Women in the highest versus lowest quartile of plasma homocysteine had modestly, but statistically non-significant, increased risks of total AMD (hazard ratio, HR, 1.24, 95% confidence interval, CI, 0.95-1.63; p for trend 0.07) and visually significant AMD (HR 1.41, 95% CI 0.92-2.17; p for trend 0.052) in age- and treatment-adjusted analyses. CONCLUSIONS: These prospective data from a large cohort of apparently healthy women do not support a strong role for homocysteine in AMD occurrence. SN - 1744-5086 UR - https://www.unboundmedicine.com/medline/citation/25777307/Prospective_study_of_plasma_homocysteine_level_and_risk_of_age_related_macular_degeneration_in_women_ L2 - http://www.tandfonline.com/doi/full/10.3109/09286586.2015.1012272 DB - PRIME DP - Unbound Medicine ER -