Tags

Type your tag names separated by a space and hit enter

Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy.
J Clin Endocrinol Metab 2015; 100(5):1967-75JC

Abstract

CONTEXT

Fetal exposure to maternal diabetes is associated with increased risk of type 2 diabetes mellitus (T2DM) later in life. The pathogenesis of T2DM involves dysfunction of the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), as well as hyperglucagonemia.

OBJECTIVE

Our aim was to investigate circulating plasma levels of GLP-1, GIP, and glucagon during the oral glucose tolerance test (OGTT) in adult offspring of women with diabetes in pregnancy.

DESIGN AND PARTICIPANTS

We conducted a follow-up study of 567 offspring, aged 18-27 years. We included two groups exposed to maternal diabetes in utero: offspring of women with diet-treated gestational diabetes mellitus (O-GDM; n = 163) or type 1 diabetes (O-T1DM; n = 146). Two reference groups were included: offspring of women with risk factors for GDM, but normoglycemia during pregnancy (O-NoGDM; n = 133) and offspring from the background population (O-BP; n = 125). The subjects underwent a 75-g OGTT with venous samples at 0, 30, and 120 minutes.

RESULTS

Fasting plasma levels of GLP-1 were lower in the two diabetes-exposed groups compared to O-BP (O-GDM, P = .040; O-T1DM, P = .008). Increasing maternal blood glucose during OGTT in pregnancy was associated with reduced postprandial suppression of glucagon in the offspring. Lower levels of GLP-1 and higher levels of glucagon during the OGTT were present in offspring characterized by overweight or prediabetes/T2DM at follow-up, irrespective of exposure status.

CONCLUSION

Lower levels of fasting GLP-1 and impaired glucagon suppression in adult offspring exposed to maternal diabetes during pregnancy are diabetogenic traits that may contribute to glucose intolerance in these persons, but further investigations are needed.

Authors+Show Affiliations

Center for Pregnant Women with Diabetes (L.K., T.D.C., E.R.M., P.D.) and Departments of Obstetrics (L.K., P.D.) and Endocrinology (E.R.M.), Rigshospitalet, DK-2100 Copenhagen, Denmark; Department of Gynaecology and Obstetrics (T.D.C.), Nordsjaellands Hospital, 3400 Hillerød, Denmark; Institute of Clinical Medicine (E.R.M., P.D.), Faculty of Health Science, University of Copenhagen, 2200 Copenhagen, Denmark; Novo Nordisk Foundation (NNF) Center for Basic Metabolic Research (T.H.), Section of Metabolic Genetics, University of Copenhagen, 2200 Copenhagen, Denmark; Faculty of Health Sciences (T.H.), University of Southern Denmark, 5230 Odense M, Denmark; and NNF Center for Basic Metabolic Research and Department of Biomedical Sciences (J.J.H.), University of Copenhagen, 2200 Copenhagen, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25781355

Citation

Kelstrup, Louise, et al. "Incretin and Glucagon Levels in Adult Offspring Exposed to Maternal Diabetes in Pregnancy." The Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 5, 2015, pp. 1967-75.
Kelstrup L, Clausen TD, Mathiesen ER, et al. Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy. J Clin Endocrinol Metab. 2015;100(5):1967-75.
Kelstrup, L., Clausen, T. D., Mathiesen, E. R., Hansen, T., Holst, J. J., & Damm, P. (2015). Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy. The Journal of Clinical Endocrinology and Metabolism, 100(5), pp. 1967-75. doi:10.1210/jc.2014-3978.
Kelstrup L, et al. Incretin and Glucagon Levels in Adult Offspring Exposed to Maternal Diabetes in Pregnancy. J Clin Endocrinol Metab. 2015;100(5):1967-75. PubMed PMID: 25781355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy. AU - Kelstrup,Louise, AU - Clausen,Tine D, AU - Mathiesen,Elisabeth R, AU - Hansen,Torben, AU - Holst,Jens J, AU - Damm,Peter, Y1 - 2015/03/17/ PY - 2015/3/18/entrez PY - 2015/3/18/pubmed PY - 2015/10/1/medline SP - 1967 EP - 75 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 100 IS - 5 N2 - CONTEXT: Fetal exposure to maternal diabetes is associated with increased risk of type 2 diabetes mellitus (T2DM) later in life. The pathogenesis of T2DM involves dysfunction of the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), as well as hyperglucagonemia. OBJECTIVE: Our aim was to investigate circulating plasma levels of GLP-1, GIP, and glucagon during the oral glucose tolerance test (OGTT) in adult offspring of women with diabetes in pregnancy. DESIGN AND PARTICIPANTS: We conducted a follow-up study of 567 offspring, aged 18-27 years. We included two groups exposed to maternal diabetes in utero: offspring of women with diet-treated gestational diabetes mellitus (O-GDM; n = 163) or type 1 diabetes (O-T1DM; n = 146). Two reference groups were included: offspring of women with risk factors for GDM, but normoglycemia during pregnancy (O-NoGDM; n = 133) and offspring from the background population (O-BP; n = 125). The subjects underwent a 75-g OGTT with venous samples at 0, 30, and 120 minutes. RESULTS: Fasting plasma levels of GLP-1 were lower in the two diabetes-exposed groups compared to O-BP (O-GDM, P = .040; O-T1DM, P = .008). Increasing maternal blood glucose during OGTT in pregnancy was associated with reduced postprandial suppression of glucagon in the offspring. Lower levels of GLP-1 and higher levels of glucagon during the OGTT were present in offspring characterized by overweight or prediabetes/T2DM at follow-up, irrespective of exposure status. CONCLUSION: Lower levels of fasting GLP-1 and impaired glucagon suppression in adult offspring exposed to maternal diabetes during pregnancy are diabetogenic traits that may contribute to glucose intolerance in these persons, but further investigations are needed. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/25781355/Incretin_and_glucagon_levels_in_adult_offspring_exposed_to_maternal_diabetes_in_pregnancy_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2014-3978 DB - PRIME DP - Unbound Medicine ER -