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The effect of vitamin K1 supplementation on sensitivity and insulin resistance via osteocalcin in prediabetic women: a double-blind randomized controlled clinical trial.

Abstract

BACKGROUND/OBJECTIVES

A relationship between osteocalcin (OC) levels and factors associated with energy metabolism and insulin resistance has been reported recently. The aim of this study was to investigate whether modulation of ostecalcin isoforms via vitamin K1 supplementation would affect glucose metabolism or insulin sensitivity in prediabetic and premenopause women.

SUBJECTS/METHODS

Eighty-two prediabetic women were randomized to consume vitamin K1 supplement (n = 39) or placebo (n = 43) for 4 weeks. Participants in the vitamin K1 supplement group received one pearl softgel capsule containing 1000 μm of phylloquinone, and the placebo group received one placebo capsule daily for 4 weeks. Blood samples were collected at baseline and after the 4-week intervention period to quantify carboxylated OC (cOC), undercarboxylated OC (ucOC) and relevant variables.

RESULTS

Phylloquinone supplementation increased the serum levels of cOC and decreased ucOC, compared with placebo (12.53 ± 5.95 compared with 7.43 ± 4.85 ng/ml and 2.47 ± 1.91 compared with 4.79 ± 2.43 ng/ml, respectively; P < 0.001). Furthermore, intake of phylloquinone supplement led to significant decreases in %ucOC (17.97 ± 12.24 compared with 43.80 ± 19.86) and 2-h post-oral glucose tolerance test (OGTT) glucose (7.32 ± 1.50 compared with 8.62 ± 1.45 mmol/l), and 2-h post-OGTT insulin level (80.34 ± 42.24 compared with 112.43 ± 53.19 μIU/ml) and increased insulin sensitivity index (2.46 ± 0.71 compared with 1.75 ± 0.61) compared with placebo. Overall, a significant association was found between changes in %ucOC and changes in 2-h post-OGTT glucose (r = 0.308, P = 0.028).

CONCLUSIONS

The results of this study demonstrated that vitamin K1 supplementation for 4 weeks did not affect insulin resistance in premenopausal and prediabetic women but had beneficial effects on glycemic status and insulin sensitivity.

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  • Authors+Show Affiliations

    ,

    Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

    ,

    Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

    ,

    Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

    ,

    Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

    ,

    Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

    ,

    Department of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

    Health Research Institute, Diabetes Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

    Source

    MeSH

    Adult
    Blood Glucose
    Dietary Supplements
    Double-Blind Method
    Female
    Glucose Tolerance Test
    Humans
    Insulin
    Insulin Resistance
    Middle Aged
    Osteocalcin
    Prediabetic State
    Premenopause
    Vitamin K 1
    Young Adult

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25782427

    Citation

    Rasekhi, H, et al. "The Effect of Vitamin K1 Supplementation On Sensitivity and Insulin Resistance Via Osteocalcin in Prediabetic Women: a Double-blind Randomized Controlled Clinical Trial." European Journal of Clinical Nutrition, vol. 69, no. 8, 2015, pp. 891-5.
    Rasekhi H, Karandish M, Jalali MT, et al. The effect of vitamin K1 supplementation on sensitivity and insulin resistance via osteocalcin in prediabetic women: a double-blind randomized controlled clinical trial. Eur J Clin Nutr. 2015;69(8):891-5.
    Rasekhi, H., Karandish, M., Jalali, M. T., Mohammad-Shahi, M., Zarei, M., Saki, A., & Shahbazian, H. (2015). The effect of vitamin K1 supplementation on sensitivity and insulin resistance via osteocalcin in prediabetic women: a double-blind randomized controlled clinical trial. European Journal of Clinical Nutrition, 69(8), pp. 891-5. doi:10.1038/ejcn.2015.17.
    Rasekhi H, et al. The Effect of Vitamin K1 Supplementation On Sensitivity and Insulin Resistance Via Osteocalcin in Prediabetic Women: a Double-blind Randomized Controlled Clinical Trial. Eur J Clin Nutr. 2015;69(8):891-5. PubMed PMID: 25782427.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The effect of vitamin K1 supplementation on sensitivity and insulin resistance via osteocalcin in prediabetic women: a double-blind randomized controlled clinical trial. AU - Rasekhi,H, AU - Karandish,M, AU - Jalali,M T, AU - Mohammad-Shahi,M, AU - Zarei,M, AU - Saki,A, AU - Shahbazian,H, Y1 - 2015/03/18/ PY - 2014/05/12/received PY - 2014/12/20/revised PY - 2015/01/16/accepted PY - 2015/3/19/entrez PY - 2015/3/19/pubmed PY - 2016/5/5/medline SP - 891 EP - 5 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 69 IS - 8 N2 - BACKGROUND/OBJECTIVES: A relationship between osteocalcin (OC) levels and factors associated with energy metabolism and insulin resistance has been reported recently. The aim of this study was to investigate whether modulation of ostecalcin isoforms via vitamin K1 supplementation would affect glucose metabolism or insulin sensitivity in prediabetic and premenopause women. SUBJECTS/METHODS: Eighty-two prediabetic women were randomized to consume vitamin K1 supplement (n = 39) or placebo (n = 43) for 4 weeks. Participants in the vitamin K1 supplement group received one pearl softgel capsule containing 1000 μm of phylloquinone, and the placebo group received one placebo capsule daily for 4 weeks. Blood samples were collected at baseline and after the 4-week intervention period to quantify carboxylated OC (cOC), undercarboxylated OC (ucOC) and relevant variables. RESULTS: Phylloquinone supplementation increased the serum levels of cOC and decreased ucOC, compared with placebo (12.53 ± 5.95 compared with 7.43 ± 4.85 ng/ml and 2.47 ± 1.91 compared with 4.79 ± 2.43 ng/ml, respectively; P < 0.001). Furthermore, intake of phylloquinone supplement led to significant decreases in %ucOC (17.97 ± 12.24 compared with 43.80 ± 19.86) and 2-h post-oral glucose tolerance test (OGTT) glucose (7.32 ± 1.50 compared with 8.62 ± 1.45 mmol/l), and 2-h post-OGTT insulin level (80.34 ± 42.24 compared with 112.43 ± 53.19 μIU/ml) and increased insulin sensitivity index (2.46 ± 0.71 compared with 1.75 ± 0.61) compared with placebo. Overall, a significant association was found between changes in %ucOC and changes in 2-h post-OGTT glucose (r = 0.308, P = 0.028). CONCLUSIONS: The results of this study demonstrated that vitamin K1 supplementation for 4 weeks did not affect insulin resistance in premenopausal and prediabetic women but had beneficial effects on glycemic status and insulin sensitivity. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/25782427/The_effect_of_vitamin_K1_supplementation_on_sensitivity_and_insulin_resistance_via_osteocalcin_in_prediabetic_women:_a_double_blind_randomized_controlled_clinical_trial_ L2 - http://dx.doi.org/10.1038/ejcn.2015.17 DB - PRIME DP - Unbound Medicine ER -