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Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia.
Gastroenterology. 1985 Mar; 88(3):638-48.G

Abstract

Endoscopic screening in 123 patients with pernicious anemia (PA) yielded 4 patients with solitary and 1 patient with multiple gastric carcinoid tumors. Quantitative histologic studies of multiple standardized biopsy specimens showed a significantly increased number of fundic mucosal argyrophil endocrine cells in 40 patients with PA when compared with 15 patients with simple fundic atrophic gastritis (p = 0.002) or 8 normal controls (p = 0.0001). Patients with simple atrophic gastritis had increased numbers of fundic mucosal argyrophil cells as compared with normal controls (p = 0.02). A significant difference was also noticed in the number of antral mucosal argyrophil cells between patients with PA and normal controls (p = 0.01), but not between patients with PA and patients with simple atrophic gastritis. It is concluded that, in addition to having hyperplasia of gastric mucosal argyrophil endocrine cells, patients with PA run an increased risk of developing gastric argyrophil cell carcinoid tumors, which should be regarded as potentially malignant.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2578420

Citation

Borch, K, et al. "Gastric Endocrine Cell Hyperplasia and Carcinoid Tumors in Pernicious Anemia." Gastroenterology, vol. 88, no. 3, 1985, pp. 638-48.
Borch K, Renvall H, Liedberg G. Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia. Gastroenterology. 1985;88(3):638-48.
Borch, K., Renvall, H., & Liedberg, G. (1985). Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia. Gastroenterology, 88(3), 638-48.
Borch K, Renvall H, Liedberg G. Gastric Endocrine Cell Hyperplasia and Carcinoid Tumors in Pernicious Anemia. Gastroenterology. 1985;88(3):638-48. PubMed PMID: 2578420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia. AU - Borch,K, AU - Renvall,H, AU - Liedberg,G, PY - 1985/3/1/pubmed PY - 1985/3/1/medline PY - 1985/3/1/entrez SP - 638 EP - 48 JF - Gastroenterology JO - Gastroenterology VL - 88 IS - 3 N2 - Endoscopic screening in 123 patients with pernicious anemia (PA) yielded 4 patients with solitary and 1 patient with multiple gastric carcinoid tumors. Quantitative histologic studies of multiple standardized biopsy specimens showed a significantly increased number of fundic mucosal argyrophil endocrine cells in 40 patients with PA when compared with 15 patients with simple fundic atrophic gastritis (p = 0.002) or 8 normal controls (p = 0.0001). Patients with simple atrophic gastritis had increased numbers of fundic mucosal argyrophil cells as compared with normal controls (p = 0.02). A significant difference was also noticed in the number of antral mucosal argyrophil cells between patients with PA and normal controls (p = 0.01), but not between patients with PA and patients with simple atrophic gastritis. It is concluded that, in addition to having hyperplasia of gastric mucosal argyrophil endocrine cells, patients with PA run an increased risk of developing gastric argyrophil cell carcinoid tumors, which should be regarded as potentially malignant. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/2578420/Gastric_endocrine_cell_hyperplasia_and_carcinoid_tumors_in_pernicious_anemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508585000774 DB - PRIME DP - Unbound Medicine ER -