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Integrated Sentinel Surveillance Linking Genetic, Antigenic, and Epidemiologic Monitoring of Influenza Vaccine-Virus Relatedness and Effectiveness During the 2013-2014 Influenza Season.
J Infect Dis. 2015 Sep 01; 212(5):726-39.JI

Abstract

BACKGROUND

Canada's Sentinel Physician Surveillance Network links genetic, antigenic, and vaccine effectiveness (VE) measures in an integrated platform of influenza monitoring, described here for the 2013-2014 influenza season of resurgent A(H1N1)pdm09 and late-season type B activity.

METHODS

VE was estimated as [1 - odds ratio] × 100% and compared vaccination status between individuals who tested positive (cases) and those who tested negative (controls) for influenza virus. Vaccine-virus relatedness was assessed by genomic sequence analysis and hemagglutination inhibition assays.

RESULTS

Analyses included 1037 controls (of whom 33% were vaccinated) and 663 cases (of whom 14% were vaccinated). A total of 415 cases tested positive for A(H1N1)pdm09 virus, 15 tested positive for A(H3N2) virus, 191 tested positive for B/Yamagata-lineage virus, 6 tested positive for B/Victoria-lineage virus, and 36 tested positive for viruses of unknown subtype or lineage. A(H1N1)pdm09 viruses belonged to clade 6B, distinguished by a K163Q substitution, but remained antigenically similar to the A/California/07/2009-like vaccine strain, with an adjusted VE of 71% (95% confidence interval [CI], 58%-80%). Most B/Yamagata-lineage viruses (83%) clustered phylogenetically with the prior (ie, 2012-2013) season's B/Wisconsin/01/2010-like clade 3 vaccine strain, while only 17% clustered with the current (ie, 2013-2014) season's B/Massachusetts/02/2012-like clade 2 vaccine strain. The adjusted VE for B/Yamagata-lineage virus was 73% (95% CI, 57%-84%), with a lower VE obtained after partial calendar-time adjustment for clade-mismatched B/Wisconsin/01/2010-like virus (VE, 63%; 95% CI, 41%-77%), compared with that for clade-matched B/Massachusetts/02/2012-like virus (VE, 88%; 95% CI, 48%-97%). No A(H3N2) viruses clustered with the A/Texas/50/2012-like clade 3C.1 vaccine strain, and more than half were antigenically mismatched, but sparse data did not support VE estimation.

CONCLUSIONS

VE corresponded with antigenically conserved A(H1N1)pdm09 and lineage-matched B/Yamagata viruses with clade-level variation. Surveillance linking genotypic, phenotypic, and epidemiologic measures of vaccine-virus relatedness and effectiveness could better inform predictions of vaccine performance and reformulation.

Authors+Show Affiliations

British Columbia Centre for Disease Control University of British Columbia, Vancouver.British Columbia Centre for Disease Control.British Columbia Centre for Disease Control.Institut national de santé publique du Québec Laval University, Québec.Public Health Ontario.University of Calgary.Public Health Ontario University of Toronto, Ontario.University of Calgary Provincial Laboratory of Public Health, Calgary, Alberta.Institut national de santé publique du Québec Universite de Montréal, Québec.British Columbia Centre for Disease Control University of British Columbia, Vancouver.University of British Columbia, Vancouver.University of Manitoba.University of Manitoba Cadham Provincial Laboratory.National Microbiology Laboratory, Winnipeg, Canada.Public Health Ontario.University of Manitoba National Microbiology Laboratory, Winnipeg, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25784728

Citation

Skowronski, Danuta M., et al. "Integrated Sentinel Surveillance Linking Genetic, Antigenic, and Epidemiologic Monitoring of Influenza Vaccine-Virus Relatedness and Effectiveness During the 2013-2014 Influenza Season." The Journal of Infectious Diseases, vol. 212, no. 5, 2015, pp. 726-39.
Skowronski DM, Chambers C, Sabaiduc S, et al. Integrated Sentinel Surveillance Linking Genetic, Antigenic, and Epidemiologic Monitoring of Influenza Vaccine-Virus Relatedness and Effectiveness During the 2013-2014 Influenza Season. J Infect Dis. 2015;212(5):726-39.
Skowronski, D. M., Chambers, C., Sabaiduc, S., De Serres, G., Winter, A. L., Dickinson, J. A., Gubbay, J., Fonseca, K., Charest, H., Krajden, M., Petric, M., Mahmud, S. M., Van Caeseele, P., Bastien, N., Eshaghi, A., & Li, Y. (2015). Integrated Sentinel Surveillance Linking Genetic, Antigenic, and Epidemiologic Monitoring of Influenza Vaccine-Virus Relatedness and Effectiveness During the 2013-2014 Influenza Season. The Journal of Infectious Diseases, 212(5), 726-39. https://doi.org/10.1093/infdis/jiv177
Skowronski DM, et al. Integrated Sentinel Surveillance Linking Genetic, Antigenic, and Epidemiologic Monitoring of Influenza Vaccine-Virus Relatedness and Effectiveness During the 2013-2014 Influenza Season. J Infect Dis. 2015 Sep 1;212(5):726-39. PubMed PMID: 25784728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Integrated Sentinel Surveillance Linking Genetic, Antigenic, and Epidemiologic Monitoring of Influenza Vaccine-Virus Relatedness and Effectiveness During the 2013-2014 Influenza Season. AU - Skowronski,Danuta M, AU - Chambers,Catharine, AU - Sabaiduc,Suzana, AU - De Serres,Gaston, AU - Winter,Anne-Luise, AU - Dickinson,James A, AU - Gubbay,Jonathan, AU - Fonseca,Kevin, AU - Charest,Hugues, AU - Krajden,Mel, AU - Petric,Martin, AU - Mahmud,Salaheddin M, AU - Van Caeseele,Paul, AU - Bastien,Nathalie, AU - Eshaghi,Alireza, AU - Li,Yan, Y1 - 2015/03/17/ PY - 2015/01/13/received PY - 2015/03/04/accepted PY - 2015/3/19/entrez PY - 2015/3/19/pubmed PY - 2015/10/27/medline KW - antigenic site KW - clade KW - genomic sequencing KW - hemagglutination inhibition KW - influenza KW - influenza A subtype KW - influenza B lineage KW - influenza vaccine KW - vaccine effectiveness SP - 726 EP - 39 JF - The Journal of infectious diseases JO - J Infect Dis VL - 212 IS - 5 N2 - BACKGROUND: Canada's Sentinel Physician Surveillance Network links genetic, antigenic, and vaccine effectiveness (VE) measures in an integrated platform of influenza monitoring, described here for the 2013-2014 influenza season of resurgent A(H1N1)pdm09 and late-season type B activity. METHODS: VE was estimated as [1 - odds ratio] × 100% and compared vaccination status between individuals who tested positive (cases) and those who tested negative (controls) for influenza virus. Vaccine-virus relatedness was assessed by genomic sequence analysis and hemagglutination inhibition assays. RESULTS: Analyses included 1037 controls (of whom 33% were vaccinated) and 663 cases (of whom 14% were vaccinated). A total of 415 cases tested positive for A(H1N1)pdm09 virus, 15 tested positive for A(H3N2) virus, 191 tested positive for B/Yamagata-lineage virus, 6 tested positive for B/Victoria-lineage virus, and 36 tested positive for viruses of unknown subtype or lineage. A(H1N1)pdm09 viruses belonged to clade 6B, distinguished by a K163Q substitution, but remained antigenically similar to the A/California/07/2009-like vaccine strain, with an adjusted VE of 71% (95% confidence interval [CI], 58%-80%). Most B/Yamagata-lineage viruses (83%) clustered phylogenetically with the prior (ie, 2012-2013) season's B/Wisconsin/01/2010-like clade 3 vaccine strain, while only 17% clustered with the current (ie, 2013-2014) season's B/Massachusetts/02/2012-like clade 2 vaccine strain. The adjusted VE for B/Yamagata-lineage virus was 73% (95% CI, 57%-84%), with a lower VE obtained after partial calendar-time adjustment for clade-mismatched B/Wisconsin/01/2010-like virus (VE, 63%; 95% CI, 41%-77%), compared with that for clade-matched B/Massachusetts/02/2012-like virus (VE, 88%; 95% CI, 48%-97%). No A(H3N2) viruses clustered with the A/Texas/50/2012-like clade 3C.1 vaccine strain, and more than half were antigenically mismatched, but sparse data did not support VE estimation. CONCLUSIONS: VE corresponded with antigenically conserved A(H1N1)pdm09 and lineage-matched B/Yamagata viruses with clade-level variation. Surveillance linking genotypic, phenotypic, and epidemiologic measures of vaccine-virus relatedness and effectiveness could better inform predictions of vaccine performance and reformulation. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/25784728/Integrated_Sentinel_Surveillance_Linking_Genetic_Antigenic_and_Epidemiologic_Monitoring_of_Influenza_Vaccine_Virus_Relatedness_and_Effectiveness_During_the_2013_2014_Influenza_Season_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiv177 DB - PRIME DP - Unbound Medicine ER -