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Integrated Sentinel Surveillance Linking Genetic, Antigenic, and Epidemiologic Monitoring of Influenza Vaccine-Virus Relatedness and Effectiveness During the 2013-2014 Influenza Season.
J Infect Dis. 2015 Sep 01; 212(5):726-39.JI

Abstract

BACKGROUND

Canada's Sentinel Physician Surveillance Network links genetic, antigenic, and vaccine effectiveness (VE) measures in an integrated platform of influenza monitoring, described here for the 2013-2014 influenza season of resurgent A(H1N1)pdm09 and late-season type B activity.

METHODS

VE was estimated as [1 - odds ratio] × 100% and compared vaccination status between individuals who tested positive (cases) and those who tested negative (controls) for influenza virus. Vaccine-virus relatedness was assessed by genomic sequence analysis and hemagglutination inhibition assays.

RESULTS

Analyses included 1037 controls (of whom 33% were vaccinated) and 663 cases (of whom 14% were vaccinated). A total of 415 cases tested positive for A(H1N1)pdm09 virus, 15 tested positive for A(H3N2) virus, 191 tested positive for B/Yamagata-lineage virus, 6 tested positive for B/Victoria-lineage virus, and 36 tested positive for viruses of unknown subtype or lineage. A(H1N1)pdm09 viruses belonged to clade 6B, distinguished by a K163Q substitution, but remained antigenically similar to the A/California/07/2009-like vaccine strain, with an adjusted VE of 71% (95% confidence interval [CI], 58%-80%). Most B/Yamagata-lineage viruses (83%) clustered phylogenetically with the prior (ie, 2012-2013) season's B/Wisconsin/01/2010-like clade 3 vaccine strain, while only 17% clustered with the current (ie, 2013-2014) season's B/Massachusetts/02/2012-like clade 2 vaccine strain. The adjusted VE for B/Yamagata-lineage virus was 73% (95% CI, 57%-84%), with a lower VE obtained after partial calendar-time adjustment for clade-mismatched B/Wisconsin/01/2010-like virus (VE, 63%; 95% CI, 41%-77%), compared with that for clade-matched B/Massachusetts/02/2012-like virus (VE, 88%; 95% CI, 48%-97%). No A(H3N2) viruses clustered with the A/Texas/50/2012-like clade 3C.1 vaccine strain, and more than half were antigenically mismatched, but sparse data did not support VE estimation.

CONCLUSIONS

VE corresponded with antigenically conserved A(H1N1)pdm09 and lineage-matched B/Yamagata viruses with clade-level variation. Surveillance linking genotypic, phenotypic, and epidemiologic measures of vaccine-virus relatedness and effectiveness could better inform predictions of vaccine performance and reformulation.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Skowronski DM
British Columbia Centre for Disease Control University of British Columbia, Vancouver.
Chambers C
British Columbia Centre for Disease Control.
Sabaiduc S
British Columbia Centre for Disease Control.
De Serres G
Institut national de santé publique du Québec Laval University, Québec.
Winter AL
Public Health Ontario.
Dickinson JA
University of Calgary.
Gubbay J
Public Health Ontario University of Toronto, Ontario.
Fonseca K
University of Calgary Provincial Laboratory of Public Health, Calgary, Alberta.
Charest H
Institut national de santé publique du Québec Universite de Montréal, Québec.
Krajden M
British Columbia Centre for Disease Control University of British Columbia, Vancouver.
Petric M
University of British Columbia, Vancouver.
Mahmud SM
University of Manitoba.
Van Caeseele P
University of Manitoba Cadham Provincial Laboratory.
Bastien N
National Microbiology Laboratory, Winnipeg, Canada.
Eshaghi A
Public Health Ontario.
Li Y
University of Manitoba National Microbiology Laboratory, Winnipeg, Canada.

MeSH

AdolescentAdultAgedAged, 80 and overCanadaChildChild, PreschoolEpidemiological MonitoringFemaleHemagglutination Inhibition TestsHumansInfluenza A Virus, H1N1 SubtypeInfluenza B virusInfluenza VaccinesInfluenza, HumanMaleMiddle AgedRNA, ViralSentinel SurveillanceSequence Analysis, DNATreatment OutcomeYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25784728

Citation

Skowronski, Danuta M., et al. "Integrated Sentinel Surveillance Linking Genetic, Antigenic, and Epidemiologic Monitoring of Influenza Vaccine-Virus Relatedness and Effectiveness During the 2013-2014 Influenza Season." The Journal of Infectious Diseases, vol. 212, no. 5, 2015, pp. 726-39.
Skowronski DM, Chambers C, Sabaiduc S, et al. Integrated Sentinel Surveillance Linking Genetic, Antigenic, and Epidemiologic Monitoring of Influenza Vaccine-Virus Relatedness and Effectiveness During the 2013-2014 Influenza Season. J Infect Dis. 2015;212(5):726-39.
Skowronski, D. M., Chambers, C., Sabaiduc, S., De Serres, G., Winter, A. L., Dickinson, J. A., Gubbay, J., Fonseca, K., Charest, H., Krajden, M., Petric, M., Mahmud, S. M., Van Caeseele, P., Bastien, N., Eshaghi, A., & Li, Y. (2015). Integrated Sentinel Surveillance Linking Genetic, Antigenic, and Epidemiologic Monitoring of Influenza Vaccine-Virus Relatedness and Effectiveness During the 2013-2014 Influenza Season. The Journal of Infectious Diseases, 212(5), 726-39. https://doi.org/10.1093/infdis/jiv177
Skowronski DM, et al. Integrated Sentinel Surveillance Linking Genetic, Antigenic, and Epidemiologic Monitoring of Influenza Vaccine-Virus Relatedness and Effectiveness During the 2013-2014 Influenza Season. J Infect Dis. 2015 Sep 1;212(5):726-39. PubMed PMID: 25784728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Integrated Sentinel Surveillance Linking Genetic, Antigenic, and Epidemiologic Monitoring of Influenza Vaccine-Virus Relatedness and Effectiveness During the 2013-2014 Influenza Season. AU - Skowronski,Danuta M, AU - Chambers,Catharine, AU - Sabaiduc,Suzana, AU - De Serres,Gaston, AU - Winter,Anne-Luise, AU - Dickinson,James A, AU - Gubbay,Jonathan, AU - Fonseca,Kevin, AU - Charest,Hugues, AU - Krajden,Mel, AU - Petric,Martin, AU - Mahmud,Salaheddin M, AU - Van Caeseele,Paul, AU - Bastien,Nathalie, AU - Eshaghi,Alireza, AU - Li,Yan, Y1 - 2015/03/17/ PY - 2015/01/13/received PY - 2015/03/04/accepted PY - 2015/3/19/entrez PY - 2015/3/19/pubmed PY - 2015/10/27/medline KW - antigenic site KW - clade KW - genomic sequencing KW - hemagglutination inhibition KW - influenza KW - influenza A subtype KW - influenza B lineage KW - influenza vaccine KW - vaccine effectiveness SP - 726 EP - 39 JF - The Journal of infectious diseases JO - J Infect Dis VL - 212 IS - 5 N2 - BACKGROUND: Canada's Sentinel Physician Surveillance Network links genetic, antigenic, and vaccine effectiveness (VE) measures in an integrated platform of influenza monitoring, described here for the 2013-2014 influenza season of resurgent A(H1N1)pdm09 and late-season type B activity. METHODS: VE was estimated as [1 - odds ratio] × 100% and compared vaccination status between individuals who tested positive (cases) and those who tested negative (controls) for influenza virus. Vaccine-virus relatedness was assessed by genomic sequence analysis and hemagglutination inhibition assays. RESULTS: Analyses included 1037 controls (of whom 33% were vaccinated) and 663 cases (of whom 14% were vaccinated). A total of 415 cases tested positive for A(H1N1)pdm09 virus, 15 tested positive for A(H3N2) virus, 191 tested positive for B/Yamagata-lineage virus, 6 tested positive for B/Victoria-lineage virus, and 36 tested positive for viruses of unknown subtype or lineage. A(H1N1)pdm09 viruses belonged to clade 6B, distinguished by a K163Q substitution, but remained antigenically similar to the A/California/07/2009-like vaccine strain, with an adjusted VE of 71% (95% confidence interval [CI], 58%-80%). Most B/Yamagata-lineage viruses (83%) clustered phylogenetically with the prior (ie, 2012-2013) season's B/Wisconsin/01/2010-like clade 3 vaccine strain, while only 17% clustered with the current (ie, 2013-2014) season's B/Massachusetts/02/2012-like clade 2 vaccine strain. The adjusted VE for B/Yamagata-lineage virus was 73% (95% CI, 57%-84%), with a lower VE obtained after partial calendar-time adjustment for clade-mismatched B/Wisconsin/01/2010-like virus (VE, 63%; 95% CI, 41%-77%), compared with that for clade-matched B/Massachusetts/02/2012-like virus (VE, 88%; 95% CI, 48%-97%). No A(H3N2) viruses clustered with the A/Texas/50/2012-like clade 3C.1 vaccine strain, and more than half were antigenically mismatched, but sparse data did not support VE estimation. CONCLUSIONS: VE corresponded with antigenically conserved A(H1N1)pdm09 and lineage-matched B/Yamagata viruses with clade-level variation. Surveillance linking genotypic, phenotypic, and epidemiologic measures of vaccine-virus relatedness and effectiveness could better inform predictions of vaccine performance and reformulation. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/25784728/Integrated_Sentinel_Surveillance_Linking_Genetic_Antigenic_and_Epidemiologic_Monitoring_of_Influenza_Vaccine_Virus_Relatedness_and_Effectiveness_During_the_2013_2014_Influenza_Season_ DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓43]

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