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Conjunctival flap covering combined with antiviral and steroid therapy for severe herpes simplex virus necrotizing stromal keratitis.
ScientificWorldJournal 2015; 2015:565964S

Abstract

Herpes simplex virus (HSV) necrotizing stromal keratitis is a common type of herpetic stromal keratitis (HSK). Antiviral medication alone cannot control the disease, and corticosteroid eye drops may aggravate the ulcer and result in corneal perforation. Amniotic membrane transplantation effectively treats superficial corneal ulcer resulting from necrotizing stromal HSK. However, the efficacy of this approach seems to be limited for more serious cases. This study presented the clinical treatment of severe HSV necrotizing stromal keratitis (ulcer depth greater than half of the corneal stroma) by conjunctival flap covering surgery in 25 patients (25 eyes) combined with antivirus and corticosteroid treatment at Shandong Eye Hospital from January 2007 to December 2013. Clinical results showed that the mean best spectacle-corrected visual acuity improved from preoperative 20/333 to postoperative 20/40 (P < 0.05). All patients recovered ocular surface stabilization. There was recurrence in two eyes, which was cured with antiviral medication. Conjunctival flap covering combined with antivirus and corticosteroid treatment is effective in treating severe HSV necrotizing stromal keratitis.

Authors+Show Affiliations

Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, 372 Jingsi Road, Jinan 250021, China ; Bascom Palmer Eye Institute, University of Miami, 1638 NW 10th Avenue, Miami, FL, USA.Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, 372 Jingsi Road, Jinan 250021, China.Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, 372 Jingsi Road, Jinan 250021, China.Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, 372 Jingsi Road, Jinan 250021, China.Bascom Palmer Eye Institute, University of Miami, 1638 NW 10th Avenue, Miami, FL, USA.Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, 372 Jingsi Road, Jinan 250021, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25785282

Citation

Gao, Hua, et al. "Conjunctival Flap Covering Combined With Antiviral and Steroid Therapy for Severe Herpes Simplex Virus Necrotizing Stromal Keratitis." TheScientificWorldJournal, vol. 2015, 2015, p. 565964.
Gao H, Jia Y, Li S, et al. Conjunctival flap covering combined with antiviral and steroid therapy for severe herpes simplex virus necrotizing stromal keratitis. ScientificWorldJournal. 2015;2015:565964.
Gao, H., Jia, Y., Li, S., Wang, T., Tan, Y., & Shi, W. (2015). Conjunctival flap covering combined with antiviral and steroid therapy for severe herpes simplex virus necrotizing stromal keratitis. TheScientificWorldJournal, 2015, p. 565964. doi:10.1155/2015/565964.
Gao H, et al. Conjunctival Flap Covering Combined With Antiviral and Steroid Therapy for Severe Herpes Simplex Virus Necrotizing Stromal Keratitis. ScientificWorldJournal. 2015;2015:565964. PubMed PMID: 25785282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Conjunctival flap covering combined with antiviral and steroid therapy for severe herpes simplex virus necrotizing stromal keratitis. AU - Gao,Hua, AU - Jia,Yanni, AU - Li,Suxia, AU - Wang,Ting, AU - Tan,Yaohong, AU - Shi,Weiyun, Y1 - 2015/02/15/ PY - 2014/07/07/received PY - 2015/01/26/revised PY - 2015/01/27/accepted PY - 2015/3/19/entrez PY - 2015/3/19/pubmed PY - 2016/4/23/medline SP - 565964 EP - 565964 JF - TheScientificWorldJournal JO - ScientificWorldJournal VL - 2015 N2 - Herpes simplex virus (HSV) necrotizing stromal keratitis is a common type of herpetic stromal keratitis (HSK). Antiviral medication alone cannot control the disease, and corticosteroid eye drops may aggravate the ulcer and result in corneal perforation. Amniotic membrane transplantation effectively treats superficial corneal ulcer resulting from necrotizing stromal HSK. However, the efficacy of this approach seems to be limited for more serious cases. This study presented the clinical treatment of severe HSV necrotizing stromal keratitis (ulcer depth greater than half of the corneal stroma) by conjunctival flap covering surgery in 25 patients (25 eyes) combined with antivirus and corticosteroid treatment at Shandong Eye Hospital from January 2007 to December 2013. Clinical results showed that the mean best spectacle-corrected visual acuity improved from preoperative 20/333 to postoperative 20/40 (P < 0.05). All patients recovered ocular surface stabilization. There was recurrence in two eyes, which was cured with antiviral medication. Conjunctival flap covering combined with antivirus and corticosteroid treatment is effective in treating severe HSV necrotizing stromal keratitis. SN - 1537-744X UR - https://www.unboundmedicine.com/medline/citation/25785282/Conjunctival_flap_covering_combined_with_antiviral_and_steroid_therapy_for_severe_herpes_simplex_virus_necrotizing_stromal_keratitis_ L2 - https://dx.doi.org/10.1155/2015/565964 DB - PRIME DP - Unbound Medicine ER -