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Strategies to overcome statin intolerance.
Expert Opin Drug Metab Toxicol. 2015 Jun; 11(6):851-5.EO

Abstract

This editorial discusses several options to overcome statin intolerance in clinical practice. For example, switching to a different statin, changing statin dosing, using lipid-lowering drugs other than statins (e.g., ezetimibe, bile acid sequestrants and fibrates, alone or in combination), or combining statins with other lipid-lowering drugs. The authors focus on the potential mechanisms involved in statin-related myopathy. New lipid-lowering drugs currently in development (e.g., cholesterol ester transfer protein inhibitors [anacetrapib] and proprotein convertase subtilisin/kexin 9 inhibitors) inhibitors may help in the management of statin intolerance while achieving low-density lipoprotein cholesterol targets as set out by the guidelines.

Authors+Show Affiliations

University of Ioannina, Medical School, Department of Internal Medicine , 45110 Ioannina , Greece.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25786568

Citation

Agouridis, Aris P., et al. "Strategies to Overcome Statin Intolerance." Expert Opinion On Drug Metabolism & Toxicology, vol. 11, no. 6, 2015, pp. 851-5.
Agouridis AP, Nair DR, Mikhailidis DP. Strategies to overcome statin intolerance. Expert Opin Drug Metab Toxicol. 2015;11(6):851-5.
Agouridis, A. P., Nair, D. R., & Mikhailidis, D. P. (2015). Strategies to overcome statin intolerance. Expert Opinion On Drug Metabolism & Toxicology, 11(6), 851-5. https://doi.org/10.1517/17425255.2015.1027685
Agouridis AP, Nair DR, Mikhailidis DP. Strategies to Overcome Statin Intolerance. Expert Opin Drug Metab Toxicol. 2015;11(6):851-5. PubMed PMID: 25786568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Strategies to overcome statin intolerance. AU - Agouridis,Aris P, AU - Nair,Devaki R, AU - Mikhailidis,Dimitri P, Y1 - 2015/03/18/ PY - 2015/3/20/entrez PY - 2015/3/20/pubmed PY - 2016/2/16/medline KW - combination therapy KW - ezetimibe KW - low-density lipoprotein cholesterol targets KW - myopathy KW - statin intolerance SP - 851 EP - 5 JF - Expert opinion on drug metabolism & toxicology JO - Expert Opin Drug Metab Toxicol VL - 11 IS - 6 N2 - This editorial discusses several options to overcome statin intolerance in clinical practice. For example, switching to a different statin, changing statin dosing, using lipid-lowering drugs other than statins (e.g., ezetimibe, bile acid sequestrants and fibrates, alone or in combination), or combining statins with other lipid-lowering drugs. The authors focus on the potential mechanisms involved in statin-related myopathy. New lipid-lowering drugs currently in development (e.g., cholesterol ester transfer protein inhibitors [anacetrapib] and proprotein convertase subtilisin/kexin 9 inhibitors) inhibitors may help in the management of statin intolerance while achieving low-density lipoprotein cholesterol targets as set out by the guidelines. SN - 1744-7607 UR - https://www.unboundmedicine.com/medline/citation/25786568/Strategies_to_overcome_statin_intolerance_ L2 - http://www.tandfonline.com/doi/full/10.1517/17425255.2015.1027685 DB - PRIME DP - Unbound Medicine ER -