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Perinatal outcomes of pregnancies complicated by preterm premature rupture of the membranes before 34 weeks of gestation in a tertiary center in China: A retrospective review.
Biosci Trends. 2015 Feb; 9(1):35-41.BT

Abstract

Preterm premature rupture of the membranes (PPROM) remains the leading cause of preterm deliveries and neonatal mortality and morbidity. The current cohort study sought to retrospectively examine perinatal outcomes in cases of PPROM < 34 weeks' gestation that were managed conservatively from 2010 to 2012 and to identify risk factors for short-term neonatal outcomes. Subjects were 510 pregnancies consisting of 114 twin and 396 singleton pregnancies. Clinical chorioamnionitis occurred in 17.8% of the pregnancies. Neonatal mortality was 7.4%, the rate of major neonatal conditions was 40%, and the rate of NICU admission was 72.9%. The latency period exceeded 48 h in 62.5% of the pregnancies and 7 days in 24.3% of the pregnancies. Twin pregnancies had a shorter latency period than singleton pregnancies (median of 2 days versus 4 days, p < 0.001). Pregnancies complicated with early vaginal bleeding had a higher neonatal mortality (13.95% vs. 6.36%, p = 0.013) and morbidity (51.16% vs. 38.32%, p = 0.024), fewer weeks of gestation at PPROM (p = 0.029). Multivariate logistic regression analysis revealed that weeks of gestation at PPROM (OR: 0.953, 95% CI: 0.939-0.966, p < 0.001) and a latency period (OR: 0.948, 95%CI: 0.926-0.970, p < 0.001) were associated with neonatal mortality or morbidity. A twin pregnancy (OR: 0.319, 95% CI: 0.17-0.6, p < 0.001) and weeks of gestation at PPROM (OR: 0.737, 95% CI: 0.66-0.822, p < 0.001) were associated with the latency period. Gestational age at PPROM, a twin pregnancy, and the latency period are associated with neonatal mortality and morbidity.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25787907

Citation

Yu, Haiyan, et al. "Perinatal Outcomes of Pregnancies Complicated By Preterm Premature Rupture of the Membranes Before 34 Weeks of Gestation in a Tertiary Center in China: a Retrospective Review." Bioscience Trends, vol. 9, no. 1, 2015, pp. 35-41.
Yu H, Wang X, Gao H, et al. Perinatal outcomes of pregnancies complicated by preterm premature rupture of the membranes before 34 weeks of gestation in a tertiary center in China: A retrospective review. Biosci Trends. 2015;9(1):35-41.
Yu, H., Wang, X., Gao, H., You, Y., & Xing, A. (2015). Perinatal outcomes of pregnancies complicated by preterm premature rupture of the membranes before 34 weeks of gestation in a tertiary center in China: A retrospective review. Bioscience Trends, 9(1), 35-41. https://doi.org/10.5582/bst.2014.01058
Yu H, et al. Perinatal Outcomes of Pregnancies Complicated By Preterm Premature Rupture of the Membranes Before 34 Weeks of Gestation in a Tertiary Center in China: a Retrospective Review. Biosci Trends. 2015;9(1):35-41. PubMed PMID: 25787907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perinatal outcomes of pregnancies complicated by preterm premature rupture of the membranes before 34 weeks of gestation in a tertiary center in China: A retrospective review. AU - Yu,Haiyan, AU - Wang,Xiaodong, AU - Gao,Haocheng, AU - You,Yong, AU - Xing,Aiyun, PY - 2015/3/20/entrez PY - 2015/3/20/pubmed PY - 2015/12/23/medline SP - 35 EP - 41 JF - Bioscience trends JO - Biosci Trends VL - 9 IS - 1 N2 - Preterm premature rupture of the membranes (PPROM) remains the leading cause of preterm deliveries and neonatal mortality and morbidity. The current cohort study sought to retrospectively examine perinatal outcomes in cases of PPROM < 34 weeks' gestation that were managed conservatively from 2010 to 2012 and to identify risk factors for short-term neonatal outcomes. Subjects were 510 pregnancies consisting of 114 twin and 396 singleton pregnancies. Clinical chorioamnionitis occurred in 17.8% of the pregnancies. Neonatal mortality was 7.4%, the rate of major neonatal conditions was 40%, and the rate of NICU admission was 72.9%. The latency period exceeded 48 h in 62.5% of the pregnancies and 7 days in 24.3% of the pregnancies. Twin pregnancies had a shorter latency period than singleton pregnancies (median of 2 days versus 4 days, p < 0.001). Pregnancies complicated with early vaginal bleeding had a higher neonatal mortality (13.95% vs. 6.36%, p = 0.013) and morbidity (51.16% vs. 38.32%, p = 0.024), fewer weeks of gestation at PPROM (p = 0.029). Multivariate logistic regression analysis revealed that weeks of gestation at PPROM (OR: 0.953, 95% CI: 0.939-0.966, p < 0.001) and a latency period (OR: 0.948, 95%CI: 0.926-0.970, p < 0.001) were associated with neonatal mortality or morbidity. A twin pregnancy (OR: 0.319, 95% CI: 0.17-0.6, p < 0.001) and weeks of gestation at PPROM (OR: 0.737, 95% CI: 0.66-0.822, p < 0.001) were associated with the latency period. Gestational age at PPROM, a twin pregnancy, and the latency period are associated with neonatal mortality and morbidity. SN - 1881-7823 UR - https://www.unboundmedicine.com/medline/citation/25787907/Perinatal_outcomes_of_pregnancies_complicated_by_preterm_premature_rupture_of_the_membranes_before_34_weeks_of_gestation_in_a_tertiary_center_in_China:_A_retrospective_review_ L2 - https://dx.doi.org/10.5582/bst.2014.01058 DB - PRIME DP - Unbound Medicine ER -