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Reduced Symptoms of Inattention after Dietary Omega-3 Fatty Acid Supplementation in Boys with and without Attention Deficit/Hyperactivity Disorder.
Neuropsychopharmacology 2015; 40(10):2298-306N

Abstract

Attention deficit/hyperactivity disorder (ADHD) is one of the most common child psychiatric disorders, and is often treated with stimulant medication. Nonpharmacological treatments include dietary supplementation with omega-3 fatty acids, although their effectiveness remains to be shown conclusively. In this study, we investigated the effects of dietary omega-3 fatty acid supplementation on ADHD symptoms and cognitive control in young boys with and without ADHD. A total of 40 boys with ADHD, aged 8-14 years, and 39 matched, typically developing controls participated in a 16-week double-blind randomized placebo-controlled trial. Participants consumed 10 g of margarine daily, enriched with either 650 mg of eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) each or placebo. Baseline and follow-up assessments addressed ADHD symptoms, fMRI of cognitive control, urine homovanillic acid, and cheek cell phospholipid sampling. EPA/DHA supplementation improved parent-rated attention in both children with ADHD and typically developing children. Phospholipid DHA level at follow-up was higher for children receiving EPA/DHA supplements than placebo. There was no effect of EPA/DHA supplementation on cognitive control or on fMRI measures of brain activity. This study shows that dietary supplementation with omega-3 fatty acids reduces symptoms of ADHD, both for individuals with ADHD and typically developing children. This effect does not appear to be mediated by cognitive control systems in the brain, as no effect of supplementation was found here. Nonetheless, this study offers support that omega-3 supplementation may be an effective augmentation for pharmacological treatments of ADHD (NCT01554462: The Effects of EPA/DHA Supplementation on Cognitive Control in Children with ADHD; http://clinicaltrials.gov/show/NCT01554462).

Authors+Show Affiliations

NICHE Lab, Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.NICHE Lab, Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.NICHE Lab, Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.NICHE Lab, Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.NICHE Lab, Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.Division of Metabolic and Nutritional Medicine, University of Munich Medical Center, Dr von Hauner Children's Hospital, Munich, Germany.Division of Metabolic and Nutritional Medicine, University of Munich Medical Center, Dr von Hauner Children's Hospital, Munich, Germany.Department of Medical Genetics and Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.Unilever Research & Development, Vlaardingen, The Netherlands.Unilever Research & Development, Vlaardingen, The Netherlands.NICHE Lab, Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25790022

Citation

Bos, Dienke J., et al. "Reduced Symptoms of Inattention After Dietary Omega-3 Fatty Acid Supplementation in Boys With and Without Attention Deficit/Hyperactivity Disorder." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 40, no. 10, 2015, pp. 2298-306.
Bos DJ, Oranje B, Veerhoek ES, et al. Reduced Symptoms of Inattention after Dietary Omega-3 Fatty Acid Supplementation in Boys with and without Attention Deficit/Hyperactivity Disorder. Neuropsychopharmacology. 2015;40(10):2298-306.
Bos, D. J., Oranje, B., Veerhoek, E. S., Van Diepen, R. M., Weusten, J. M., Demmelmair, H., ... Durston, S. (2015). Reduced Symptoms of Inattention after Dietary Omega-3 Fatty Acid Supplementation in Boys with and without Attention Deficit/Hyperactivity Disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 40(10), pp. 2298-306. doi:10.1038/npp.2015.73.
Bos DJ, et al. Reduced Symptoms of Inattention After Dietary Omega-3 Fatty Acid Supplementation in Boys With and Without Attention Deficit/Hyperactivity Disorder. Neuropsychopharmacology. 2015;40(10):2298-306. PubMed PMID: 25790022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced Symptoms of Inattention after Dietary Omega-3 Fatty Acid Supplementation in Boys with and without Attention Deficit/Hyperactivity Disorder. AU - Bos,Dienke J, AU - Oranje,Bob, AU - Veerhoek,E Sanne, AU - Van Diepen,Rosanne M, AU - Weusten,Juliette Mh, AU - Demmelmair,Hans, AU - Koletzko,Berthold, AU - de Sain-van der Velden,Monique Gm, AU - Eilander,Ans, AU - Hoeksma,Marco, AU - Durston,Sarah, Y1 - 2015/03/19/ PY - 2014/11/05/received PY - 2014/12/17/revised PY - 2015/03/10/accepted PY - 2015/3/20/entrez PY - 2015/3/20/pubmed PY - 2016/5/10/medline SP - 2298 EP - 306 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 40 IS - 10 N2 - Attention deficit/hyperactivity disorder (ADHD) is one of the most common child psychiatric disorders, and is often treated with stimulant medication. Nonpharmacological treatments include dietary supplementation with omega-3 fatty acids, although their effectiveness remains to be shown conclusively. In this study, we investigated the effects of dietary omega-3 fatty acid supplementation on ADHD symptoms and cognitive control in young boys with and without ADHD. A total of 40 boys with ADHD, aged 8-14 years, and 39 matched, typically developing controls participated in a 16-week double-blind randomized placebo-controlled trial. Participants consumed 10 g of margarine daily, enriched with either 650 mg of eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) each or placebo. Baseline and follow-up assessments addressed ADHD symptoms, fMRI of cognitive control, urine homovanillic acid, and cheek cell phospholipid sampling. EPA/DHA supplementation improved parent-rated attention in both children with ADHD and typically developing children. Phospholipid DHA level at follow-up was higher for children receiving EPA/DHA supplements than placebo. There was no effect of EPA/DHA supplementation on cognitive control or on fMRI measures of brain activity. This study shows that dietary supplementation with omega-3 fatty acids reduces symptoms of ADHD, both for individuals with ADHD and typically developing children. This effect does not appear to be mediated by cognitive control systems in the brain, as no effect of supplementation was found here. Nonetheless, this study offers support that omega-3 supplementation may be an effective augmentation for pharmacological treatments of ADHD (NCT01554462: The Effects of EPA/DHA Supplementation on Cognitive Control in Children with ADHD; http://clinicaltrials.gov/show/NCT01554462). SN - 1740-634X UR - https://www.unboundmedicine.com/medline/citation/25790022/Reduced_Symptoms_of_Inattention_after_Dietary_Omega_3_Fatty_Acid_Supplementation_in_Boys_with_and_without_Attention_Deficit/Hyperactivity_Disorder_ L2 - http://dx.doi.org/10.1038/npp.2015.73 DB - PRIME DP - Unbound Medicine ER -