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Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case-control study.
Cancer Causes Control. 2015 Jun; 26(6):871-9.CC

Abstract

PURPOSE

The etiology of childhood brain tumors (CBT) is poorly understood, but dietary factors could be involved. In this case-control study of CBT, the possible associations of childhood intake of dietary and supplemental folate, vitamin B6, and vitamin B12 with the risk of CBT were investigated, along with various food groups.

METHODS

Cases diagnosed between 2005 and 2010 were identified from 10 pediatric oncology centers in Australia and controls by nationwide random-digit dialling. For study children of ages 3-14 years, diet in the year before diagnosis (or recruitment) was assessed using food frequency questionnaires. Folate intake was adjusted for bioavailability, and dietary micronutrient intake was energy-adjusted. Micronutrients and food groups were analyzed using logistic regression adjusting for relevant confounders. Principal components analysis was conducted to assess food group intake patterns for analysis.

RESULTS

Food and micronutrient data were available for 216 cases and 523 controls. Folate intake was associated with a reduced risk of CBT overall (odds ratio for highest tertile vs. lowest: 0.63, 95% confidence interval 0.41, 0.97) and particularly low-grade gliomas (odds ratio for highest tertile vs. lowest: 0.52, 95% confidence interval 0.29, 0.92). Vitamin B6 and B12 intake was not associated with CBT risk, nor was processed meat.

CONCLUSIONS

High folate intake during childhood may reduce the risk of CBT. This potentially important finding needs to be corroborated in other studies. If replicated, these results could have important implications for public health recommendations regarding diet during childhood.

Authors+Show Affiliations

Telethon Kids Institute, University of Western Australia, PO Box 855, West Perth 6872, Perth, WA, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25791129

Citation

Greenop, Kathryn R., et al. "Childhood Folate, B6, B12, and Food Group Intake and the Risk of Childhood Brain Tumors: Results From an Australian Case-control Study." Cancer Causes & Control : CCC, vol. 26, no. 6, 2015, pp. 871-9.
Greenop KR, Miller M, Bailey HD, et al. Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case-control study. Cancer Causes Control. 2015;26(6):871-9.
Greenop, K. R., Miller, M., Bailey, H. D., de Klerk, N. H., Attia, J., Kellie, S. J., Bower, C., Armstrong, B. K., & Milne, E. (2015). Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case-control study. Cancer Causes & Control : CCC, 26(6), 871-9. https://doi.org/10.1007/s10552-015-0562-z
Greenop KR, et al. Childhood Folate, B6, B12, and Food Group Intake and the Risk of Childhood Brain Tumors: Results From an Australian Case-control Study. Cancer Causes Control. 2015;26(6):871-9. PubMed PMID: 25791129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case-control study. AU - Greenop,Kathryn R, AU - Miller,Margaret, AU - Bailey,Helen D, AU - de Klerk,Nicholas H, AU - Attia,John, AU - Kellie,Stewart J, AU - Bower,Carol, AU - Armstrong,Bruce K, AU - Milne,Elizabeth, Y1 - 2015/03/20/ PY - 2014/11/19/received PY - 2015/03/12/accepted PY - 2015/3/21/entrez PY - 2015/3/21/pubmed PY - 2016/4/7/medline SP - 871 EP - 9 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 26 IS - 6 N2 - PURPOSE: The etiology of childhood brain tumors (CBT) is poorly understood, but dietary factors could be involved. In this case-control study of CBT, the possible associations of childhood intake of dietary and supplemental folate, vitamin B6, and vitamin B12 with the risk of CBT were investigated, along with various food groups. METHODS: Cases diagnosed between 2005 and 2010 were identified from 10 pediatric oncology centers in Australia and controls by nationwide random-digit dialling. For study children of ages 3-14 years, diet in the year before diagnosis (or recruitment) was assessed using food frequency questionnaires. Folate intake was adjusted for bioavailability, and dietary micronutrient intake was energy-adjusted. Micronutrients and food groups were analyzed using logistic regression adjusting for relevant confounders. Principal components analysis was conducted to assess food group intake patterns for analysis. RESULTS: Food and micronutrient data were available for 216 cases and 523 controls. Folate intake was associated with a reduced risk of CBT overall (odds ratio for highest tertile vs. lowest: 0.63, 95% confidence interval 0.41, 0.97) and particularly low-grade gliomas (odds ratio for highest tertile vs. lowest: 0.52, 95% confidence interval 0.29, 0.92). Vitamin B6 and B12 intake was not associated with CBT risk, nor was processed meat. CONCLUSIONS: High folate intake during childhood may reduce the risk of CBT. This potentially important finding needs to be corroborated in other studies. If replicated, these results could have important implications for public health recommendations regarding diet during childhood. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/25791129/Childhood_folate_B6_B12_and_food_group_intake_and_the_risk_of_childhood_brain_tumors:_results_from_an_Australian_case_control_study_ L2 - https://doi.org/10.1007/s10552-015-0562-z DB - PRIME DP - Unbound Medicine ER -