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A study of migraine characteristics in joint hypermobility syndrome a.k.a. Ehlers-Danlos syndrome, hypermobility type.
Neurol Sci 2015; 36(8):1417-24NS

Abstract

Joint hypermobility syndrome (JHS) and Ehlers-Danlos syndrome, hypermobility type (EDS-HT) are two clinically overlapping heritable connective tissue disorders strongly associated with musculoskeletal pain, fatigue and headache. Migraine with or without aura is considered the most common form of headache in JHS/EDS-HT. In this population of chronically ill patients, we investigated whether migraine characteristics were different from those of a control population of migraine patients. The study was carried out on 33 selected JHS/EDS-HT patients, diagnosed according to current criteria. Sixty-six migraine subjects matching age and gender were consecutively selected as controls (MO group) among patients attending our Headache Clinic. JHS/EDS-HT and MO were screened for a series of headache characteristics, such as frequency, intensity, age of onset, level of disability, use of rescue and prophylactic medications. Differences between the two groups were tested by using independent group comparisons. Results showed that in JHS/EDS-HT: (1) migraine has an earlier onset (12.6 vs 17 years of age; p = 0.005); (2) the rate of migraine days/month is higher (15 vs 9.3 days/month; p = 0.01); (3) accompanying symptoms are usually more frequent; (4) HIT-6 and MIDAS scores are higher (p = 0.04 and p = 0.03); (5) efficacy of rescue medication is almost identical, although, total drug consumption is significantly lower (p < 0.04). Joint hypermobility syndrome and Ehlers-Danlos syndrome, hypermobility type patients have a more severe headache syndrome with respect to the MO group, therefore demonstrating that migraine has a very high impact on quality of life in this disease.

Authors+Show Affiliations

Department of Neurology and Psychiatry, Sapienza University of Rome, Viale dell'Università 30, 00185, Rome, Italy, fpuledda@hotmail.it.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25791889

Citation

Puledda, Francesca, et al. "A Study of Migraine Characteristics in Joint Hypermobility Syndrome A.k.a. Ehlers-Danlos Syndrome, Hypermobility Type." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 36, no. 8, 2015, pp. 1417-24.
Puledda F, Viganò A, Celletti C, et al. A study of migraine characteristics in joint hypermobility syndrome a.k.a. Ehlers-Danlos syndrome, hypermobility type. Neurol Sci. 2015;36(8):1417-24.
Puledda, F., Viganò, A., Celletti, C., Petolicchio, B., Toscano, M., Vicenzini, E., ... Di Piero, V. (2015). A study of migraine characteristics in joint hypermobility syndrome a.k.a. Ehlers-Danlos syndrome, hypermobility type. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 36(8), pp. 1417-24. doi:10.1007/s10072-015-2173-6.
Puledda F, et al. A Study of Migraine Characteristics in Joint Hypermobility Syndrome A.k.a. Ehlers-Danlos Syndrome, Hypermobility Type. Neurol Sci. 2015;36(8):1417-24. PubMed PMID: 25791889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A study of migraine characteristics in joint hypermobility syndrome a.k.a. Ehlers-Danlos syndrome, hypermobility type. AU - Puledda,Francesca, AU - Viganò,Alessandro, AU - Celletti,Claudia, AU - Petolicchio,Barbara, AU - Toscano,Massimiliano, AU - Vicenzini,Edoardo, AU - Castori,Marco, AU - Laudani,Guido, AU - Valente,Donatella, AU - Camerota,Filippo, AU - Di Piero,Vittorio, Y1 - 2015/03/20/ PY - 2014/12/29/received PY - 2015/03/13/accepted PY - 2015/3/21/entrez PY - 2015/3/21/pubmed PY - 2016/4/20/medline SP - 1417 EP - 24 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol. Sci. VL - 36 IS - 8 N2 - Joint hypermobility syndrome (JHS) and Ehlers-Danlos syndrome, hypermobility type (EDS-HT) are two clinically overlapping heritable connective tissue disorders strongly associated with musculoskeletal pain, fatigue and headache. Migraine with or without aura is considered the most common form of headache in JHS/EDS-HT. In this population of chronically ill patients, we investigated whether migraine characteristics were different from those of a control population of migraine patients. The study was carried out on 33 selected JHS/EDS-HT patients, diagnosed according to current criteria. Sixty-six migraine subjects matching age and gender were consecutively selected as controls (MO group) among patients attending our Headache Clinic. JHS/EDS-HT and MO were screened for a series of headache characteristics, such as frequency, intensity, age of onset, level of disability, use of rescue and prophylactic medications. Differences between the two groups were tested by using independent group comparisons. Results showed that in JHS/EDS-HT: (1) migraine has an earlier onset (12.6 vs 17 years of age; p = 0.005); (2) the rate of migraine days/month is higher (15 vs 9.3 days/month; p = 0.01); (3) accompanying symptoms are usually more frequent; (4) HIT-6 and MIDAS scores are higher (p = 0.04 and p = 0.03); (5) efficacy of rescue medication is almost identical, although, total drug consumption is significantly lower (p < 0.04). Joint hypermobility syndrome and Ehlers-Danlos syndrome, hypermobility type patients have a more severe headache syndrome with respect to the MO group, therefore demonstrating that migraine has a very high impact on quality of life in this disease. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/25791889/A_study_of_migraine_characteristics_in_joint_hypermobility_syndrome_a_k_a__Ehlers_Danlos_syndrome_hypermobility_type_ L2 - https://dx.doi.org/10.1007/s10072-015-2173-6 DB - PRIME DP - Unbound Medicine ER -