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Gestational urinary bisphenol A and maternal and newborn thyroid hormone concentrations: the HOME Study.
Environ Res. 2015 Apr; 138:453-60.ER

Abstract

Bisphenol A (BPA), an endocrine disruptor used in consumer products, may perturb thyroid function. Prenatal BPA exposure may have sex-specific effects on thyroid hormones (THs). Our objectives were to investigate whether maternal urinary BPA concentrations during pregnancy were associated with THs in maternal or cord serum, and whether these associations differed by newborn sex or maternal iodine status. We measured urinary BPA concentrations at 16 and 26 weeks gestation among pregnant women in the HOME Study (2003-2006, Cincinnati, Ohio). Thyroid stimulating hormone (TSH) and free and total thyroxine (T4) and triiodothyronine (T3) were measured in maternal serum at 16 weeks (n=181) and cord serum at delivery (n=249). Associations between BPA concentrations and maternal or cord serum TH levels were estimated by multivariable linear regression. Mean maternal urinary BPA was not associated with cord THs in all newborns, but a 10-fold increase in mean BPA was associated with lower cord TSH in girls (percent change=-36.0%; 95% confidence interval (CI): -58.4, -1.7%), but not boys (7.8%; 95% CI: -28.5, 62.7%; p-for-effect modification=0.09). We observed no significant associations between 16-week BPA and THs in maternal or cord serum, but 26-week maternal BPA was inversely associated with TSH in girls (-42.9%; 95% CI: -59.9, -18.5%), but not boys (7.6%; 95% CI: -17.3, 40.2%; p-for-effect modification=0.005) at birth. The inverse BPA-TSH relation among girls was stronger, but less precise, among iodine deficient versus sufficient mothers. Prenatal BPA exposure may reduce TSH among newborn girls, particularly when exposure occurs later in gestation.

Authors+Show Affiliations

Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA. Electronic address: megan_romano@brown.edu.Child and Family Research Institute, BC Children's and Women's Hospital and Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada.Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA.Department of Biology, University of Massachusetts, Amherst, MA, USA.Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA.Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.Children's Environmental Health and Disease Prevention Research Center and Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.Division of General and Community Pediatrics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.Child and Family Research Institute, BC Children's and Women's Hospital and Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada.Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25794847

Citation

Romano, Megan E., et al. "Gestational Urinary Bisphenol a and Maternal and Newborn Thyroid Hormone Concentrations: the HOME Study." Environmental Research, vol. 138, 2015, pp. 453-60.
Romano ME, Webster GM, Vuong AM, et al. Gestational urinary bisphenol A and maternal and newborn thyroid hormone concentrations: the HOME Study. Environ Res. 2015;138:453-60.
Romano, M. E., Webster, G. M., Vuong, A. M., Thomas Zoeller, R., Chen, A., Hoofnagle, A. N., Calafat, A. M., Karagas, M. R., Yolton, K., Lanphear, B. P., & Braun, J. M. (2015). Gestational urinary bisphenol A and maternal and newborn thyroid hormone concentrations: the HOME Study. Environmental Research, 138, 453-60. https://doi.org/10.1016/j.envres.2015.03.003
Romano ME, et al. Gestational Urinary Bisphenol a and Maternal and Newborn Thyroid Hormone Concentrations: the HOME Study. Environ Res. 2015;138:453-60. PubMed PMID: 25794847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gestational urinary bisphenol A and maternal and newborn thyroid hormone concentrations: the HOME Study. AU - Romano,Megan E, AU - Webster,Glenys M, AU - Vuong,Ann M, AU - Thomas Zoeller,R, AU - Chen,Aimin, AU - Hoofnagle,Andrew N, AU - Calafat,Antonia M, AU - Karagas,Margaret R, AU - Yolton,Kimberly, AU - Lanphear,Bruce P, AU - Braun,Joseph M, Y1 - 2015/03/17/ PY - 2014/12/01/received PY - 2015/02/14/revised PY - 2015/03/08/accepted PY - 2015/3/22/entrez PY - 2015/3/22/pubmed PY - 2015/6/16/medline KW - Bisphenol A KW - Endocrine disruptors KW - Epidemiology KW - Newborns KW - Pregnant women KW - Thyroid hormones KW - Thyroid stimulating hormone KW - Thyroxine KW - Triiodothyronine SP - 453 EP - 60 JF - Environmental research JO - Environ. Res. VL - 138 N2 - Bisphenol A (BPA), an endocrine disruptor used in consumer products, may perturb thyroid function. Prenatal BPA exposure may have sex-specific effects on thyroid hormones (THs). Our objectives were to investigate whether maternal urinary BPA concentrations during pregnancy were associated with THs in maternal or cord serum, and whether these associations differed by newborn sex or maternal iodine status. We measured urinary BPA concentrations at 16 and 26 weeks gestation among pregnant women in the HOME Study (2003-2006, Cincinnati, Ohio). Thyroid stimulating hormone (TSH) and free and total thyroxine (T4) and triiodothyronine (T3) were measured in maternal serum at 16 weeks (n=181) and cord serum at delivery (n=249). Associations between BPA concentrations and maternal or cord serum TH levels were estimated by multivariable linear regression. Mean maternal urinary BPA was not associated with cord THs in all newborns, but a 10-fold increase in mean BPA was associated with lower cord TSH in girls (percent change=-36.0%; 95% confidence interval (CI): -58.4, -1.7%), but not boys (7.8%; 95% CI: -28.5, 62.7%; p-for-effect modification=0.09). We observed no significant associations between 16-week BPA and THs in maternal or cord serum, but 26-week maternal BPA was inversely associated with TSH in girls (-42.9%; 95% CI: -59.9, -18.5%), but not boys (7.6%; 95% CI: -17.3, 40.2%; p-for-effect modification=0.005) at birth. The inverse BPA-TSH relation among girls was stronger, but less precise, among iodine deficient versus sufficient mothers. Prenatal BPA exposure may reduce TSH among newborn girls, particularly when exposure occurs later in gestation. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/25794847/Gestational_urinary_bisphenol_A_and_maternal_and_newborn_thyroid_hormone_concentrations:_the_HOME_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(15)00074-2 DB - PRIME DP - Unbound Medicine ER -