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In vitro release of metformin from iron (III) cross-linked alginate-carboxymethyl cellulose hydrogel beads.
Int J Biol Macromol. 2015; 77:114-9.IJ

Abstract

In the present study, sodium alginate (NaAlg)/sodium carboxymethyl cellulose (NaCMC) blend hydrogel beads were prepared in ferric chloride solution. The developed hydrogel beads exhibited pH sensitive for deliver Metformin hydrochloride (MH). Preparation conditions of the beads (ferric chloride solution) were significantly affected the encapsulation efficiency, swelling and in vitro release profiles of the beads. Swelling studies were accomplished in gastric and intestine stimuli atmosphere at 37°C. The swelling studies reveal that the beads at pH 7.4 showed higher swelling properties compare to pH 1.2. Exterior morphology of beads was analyzed by scanning electron microscope. SEM indicates the surface of the beads is spherical with smooth surface and size of beads drastically reduced with increasing crosslinker concentration. The crosslinking reaction between NaAlg and NaCMC with ferric chloride was confirmed by FTIR analysis. XRD analysis indicates that MH drug molecularly dispersed in the polymer matrix. In vitro release studies of MH loaded beads showed higher release profiles at pH 7.4 compared to pH 1.2. The polymeric matrices followed slightly deviation with Fickian diffusion and fit for experimental co-relation (r(2)) values.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Swamy BY
Division of Semiconductor and Chemical Engineering, Chonbuk National University, Jeonju, Chonbuk 561-756, Republic of Korea.
Yun YS
Division of Semiconductor and Chemical Engineering, Chonbuk National University, Jeonju, Chonbuk 561-756, Republic of Korea. Electronic address: ysyun@jbnu.ac.kr.

MeSH

AlginatesCarboxymethylcellulose SodiumChloridesDrug CarriersDrug LiberationFerric CompoundsGlucuronic AcidHexuronic AcidsHydrogel, Polyethylene Glycol DimethacrylateIronKineticsMetforminMicrospheres

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25796449

Citation

Swamy, Bala Yerri, and Yeoung-Sang Yun. "In Vitro Release of Metformin From Iron (III) Cross-linked Alginate-carboxymethyl Cellulose Hydrogel Beads." International Journal of Biological Macromolecules, vol. 77, 2015, pp. 114-9.
Swamy BY, Yun YS. In vitro release of metformin from iron (III) cross-linked alginate-carboxymethyl cellulose hydrogel beads. Int J Biol Macromol. 2015;77:114-9.
Swamy, B. Y., & Yun, Y. S. (2015). In vitro release of metformin from iron (III) cross-linked alginate-carboxymethyl cellulose hydrogel beads. International Journal of Biological Macromolecules, 77, 114-9. https://doi.org/10.1016/j.ijbiomac.2015.03.019
Swamy BY, Yun YS. In Vitro Release of Metformin From Iron (III) Cross-linked Alginate-carboxymethyl Cellulose Hydrogel Beads. Int J Biol Macromol. 2015;77:114-9. PubMed PMID: 25796449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro release of metformin from iron (III) cross-linked alginate-carboxymethyl cellulose hydrogel beads. AU - Swamy,Bala Yerri, AU - Yun,Yeoung-Sang, Y1 - 2015/03/19/ PY - 2015/01/30/received PY - 2015/03/09/revised PY - 2015/03/10/accepted PY - 2015/3/23/entrez PY - 2015/3/23/pubmed PY - 2016/2/5/medline KW - Hydrogel beads KW - Metformin hydrochloride (MH) KW - Sodium alginate (NaAlg) KW - Sodium carboxymethyl cellulose (NaCMC) KW - pH sensitive SP - 114 EP - 9 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 77 N2 - In the present study, sodium alginate (NaAlg)/sodium carboxymethyl cellulose (NaCMC) blend hydrogel beads were prepared in ferric chloride solution. The developed hydrogel beads exhibited pH sensitive for deliver Metformin hydrochloride (MH). Preparation conditions of the beads (ferric chloride solution) were significantly affected the encapsulation efficiency, swelling and in vitro release profiles of the beads. Swelling studies were accomplished in gastric and intestine stimuli atmosphere at 37°C. The swelling studies reveal that the beads at pH 7.4 showed higher swelling properties compare to pH 1.2. Exterior morphology of beads was analyzed by scanning electron microscope. SEM indicates the surface of the beads is spherical with smooth surface and size of beads drastically reduced with increasing crosslinker concentration. The crosslinking reaction between NaAlg and NaCMC with ferric chloride was confirmed by FTIR analysis. XRD analysis indicates that MH drug molecularly dispersed in the polymer matrix. In vitro release studies of MH loaded beads showed higher release profiles at pH 7.4 compared to pH 1.2. The polymeric matrices followed slightly deviation with Fickian diffusion and fit for experimental co-relation (r(2)) values. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/25796449/In_vitro_release_of_metformin_from_iron__III__cross_linked_alginate_carboxymethyl_cellulose_hydrogel_beads_ DB - PRIME DP - Unbound Medicine ER -