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[Effect of tobacco smoking on albumin concentration and β-glucuronidase activity in urine of smelters].
Przegl Lek 2014; 71(11):581-4PL

Abstract

The aim of present study was to estimate the nephrotoxicity of occupational exposure to heavy metals on albumin concentration and β-glucuronidase activity in the urine of smoking and non-smoking smelters. The study was performed in urine of 101 smoking and non-smoking smelters as well as 65 smoking and non-smoking male subjects unexposed to heavy metals. Section into smoking and non-smoking groups was made on basis on direct personal interview and by determination of serum cotinine concentration. The concentration of albumin in urine was measured with commercial test (Micro-Albumin ELISA Cat. No 5MA 74212, ORGENTEC Diagnostika Gmbh, Germany). The activity of β-glucuronidase in urine were determined in urine using 4-nitrophenyl β D-glucuronide (Cat. No 73677, Sigma Aldrich, Germany) as a substrate. We have observed higher albumin concentration and β-glucuronidase activity in urine of smoking and non-smoking smelters when compared to control groups. We have also found the influence of tobacco smoke as well as amount of cigarettes smoked on albumin concentration in urine of smoking smelters. A statistically significant difference was detected between activity of β-glucuronidase in urine of smoking and non-smoking smelters, which suggest as additional negative factor of exposure to tobacco smoke. Analyzing the impact of smoking intensity we have found higher albumin concentration and β-glucuronidase activity in urine of smelters smoking ≥20 cigarettes per day when compared to smelters smoking <20 cigarettes per day. The elevation of albumin concentration and β-glucuronidase activity in urine of workers occupational exposure to heavy metals and tobacco smoke indicated, that environmental exposure on these factors can disorders kidney functions.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
English Abstract
Journal Article

Language

pol

PubMed ID

25799848

Citation

Bizonń, Anna, et al. "[Effect of Tobacco Smoking On Albumin Concentration and Β-glucuronidase Activity in Urine of Smelters]." Przeglad Lekarski, vol. 71, no. 11, 2014, pp. 581-4.
Bizonń A, Witt K, Milnerowicz M, et al. [Effect of tobacco smoking on albumin concentration and β-glucuronidase activity in urine of smelters]. Prz Lek. 2014;71(11):581-4.
Bizonń, A., Witt, K., Milnerowicz, M., & Milnerowicz, H. (2014). [Effect of tobacco smoking on albumin concentration and β-glucuronidase activity in urine of smelters]. Przeglad Lekarski, 71(11), pp. 581-4.
Bizonń A, et al. [Effect of Tobacco Smoking On Albumin Concentration and Β-glucuronidase Activity in Urine of Smelters]. Prz Lek. 2014;71(11):581-4. PubMed PMID: 25799848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of tobacco smoking on albumin concentration and β-glucuronidase activity in urine of smelters]. AU - Bizonń,Anna, AU - Witt,Katarzyna, AU - Milnerowicz,Malgorzata, AU - Milnerowicz,Halina, PY - 2015/3/25/entrez PY - 2014/1/1/pubmed PY - 2015/4/10/medline SP - 581 EP - 4 JF - Przeglad lekarski JO - Prz. Lek. VL - 71 IS - 11 N2 - The aim of present study was to estimate the nephrotoxicity of occupational exposure to heavy metals on albumin concentration and β-glucuronidase activity in the urine of smoking and non-smoking smelters. The study was performed in urine of 101 smoking and non-smoking smelters as well as 65 smoking and non-smoking male subjects unexposed to heavy metals. Section into smoking and non-smoking groups was made on basis on direct personal interview and by determination of serum cotinine concentration. The concentration of albumin in urine was measured with commercial test (Micro-Albumin ELISA Cat. No 5MA 74212, ORGENTEC Diagnostika Gmbh, Germany). The activity of β-glucuronidase in urine were determined in urine using 4-nitrophenyl β D-glucuronide (Cat. No 73677, Sigma Aldrich, Germany) as a substrate. We have observed higher albumin concentration and β-glucuronidase activity in urine of smoking and non-smoking smelters when compared to control groups. We have also found the influence of tobacco smoke as well as amount of cigarettes smoked on albumin concentration in urine of smoking smelters. A statistically significant difference was detected between activity of β-glucuronidase in urine of smoking and non-smoking smelters, which suggest as additional negative factor of exposure to tobacco smoke. Analyzing the impact of smoking intensity we have found higher albumin concentration and β-glucuronidase activity in urine of smelters smoking ≥20 cigarettes per day when compared to smelters smoking <20 cigarettes per day. The elevation of albumin concentration and β-glucuronidase activity in urine of workers occupational exposure to heavy metals and tobacco smoke indicated, that environmental exposure on these factors can disorders kidney functions. SN - 0033-2240 UR - https://www.unboundmedicine.com/medline/citation/25799848/[Effect_of_tobacco_smoking_on_albumin_concentration_and_β_glucuronidase_activity_in_urine_of_smelters]_ L2 - https://medlineplus.gov/occupationalhealth.html DB - PRIME DP - Unbound Medicine ER -