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Epileptic encephalopathy with electrical status epilepticus: an electroclinical study of 59 patients.
Seizure. 2015 Mar; 26:86-93.S

Abstract

PURPOSE

To evaluate the electroclinical features, treatment effectiveness, and outcome of 59 patients with epileptic encephalopathy with electrical status epilepticus during sleep.

METHODS

Medical-files of 59 patients with electrical status epilepticus during sleep were retrospectively evaluated for data concerning: history, physical and neurological examinations, sleep and awake EEG's, psychometric tests and brain MRI.

RESULTS

A total of 31 boys and 28 girls were identified. Patients were evaluated in two groups: symptomatic/structural and idiopathic group. There was no significant difference between the etiological groups in term of mean age at ESES onset, mean interval between the first seizure and the onset of ESES. The mean age at seizure onset was earlier in the symptomatic/structural group than the idiopathic ones. The mean follow-up time after the ESES onset was 4.5 years for all patients. The most effective antiepileptic drugs in our series were clobazam and levetiracetam. In refractory patients, steroid treatment was found effective during the early course of the disease. In the idiopathic group, cognitive decline has improved. However in the symptomatic group, patients did not respond to the treatment and cognitive deterioration did not improve in one third of the group.

CONCLUSION

The long-term outcome of ESES is highly variable and usually depends on etiology and the duration of ESES. The most efficious antiepileptic drugs in our study are clobazam and levetiracetam.

Authors+Show Affiliations

Gazi University Faculty of Medicine, Pediatric Neurology, Turkey. Electronic address: mehmetarhan@gmail.com.Gazi University Faculty of Medicine, Pediatric Neurology, Turkey.Gazi University Faculty of Medicine, Pediatric Neurology, Turkey.Gazi University Faculty of Medicine, Pediatric Neurology, Turkey.Gazi University Faculty of Medicine, Pediatric Neurology, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25799908

Citation

Arhan, Ebru, et al. "Epileptic Encephalopathy With Electrical Status Epilepticus: an Electroclinical Study of 59 Patients." Seizure, vol. 26, 2015, pp. 86-93.
Arhan E, Serdaroglu A, Aydin K, et al. Epileptic encephalopathy with electrical status epilepticus: an electroclinical study of 59 patients. Seizure. 2015;26:86-93.
Arhan, E., Serdaroglu, A., Aydin, K., Hırfanoglu, T., & Soysal, A. S. (2015). Epileptic encephalopathy with electrical status epilepticus: an electroclinical study of 59 patients. Seizure, 26, 86-93. https://doi.org/10.1016/j.seizure.2015.01.008
Arhan E, et al. Epileptic Encephalopathy With Electrical Status Epilepticus: an Electroclinical Study of 59 Patients. Seizure. 2015;26:86-93. PubMed PMID: 25799908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epileptic encephalopathy with electrical status epilepticus: an electroclinical study of 59 patients. AU - Arhan,Ebru, AU - Serdaroglu,Ayse, AU - Aydin,Kursad, AU - Hırfanoglu,Tugba, AU - Soysal,A Sebnem, Y1 - 2015/02/04/ PY - 2014/10/28/received PY - 2015/01/09/revised PY - 2015/01/10/accepted PY - 2015/3/25/entrez PY - 2015/3/25/pubmed PY - 2015/12/15/medline KW - Epileptic encephalopathy with electrical status epilepticus during sleep KW - Neuropsychological aspects KW - Symptomatic and idiopathic KW - Treatment SP - 86 EP - 93 JF - Seizure JO - Seizure VL - 26 N2 - PURPOSE: To evaluate the electroclinical features, treatment effectiveness, and outcome of 59 patients with epileptic encephalopathy with electrical status epilepticus during sleep. METHODS: Medical-files of 59 patients with electrical status epilepticus during sleep were retrospectively evaluated for data concerning: history, physical and neurological examinations, sleep and awake EEG's, psychometric tests and brain MRI. RESULTS: A total of 31 boys and 28 girls were identified. Patients were evaluated in two groups: symptomatic/structural and idiopathic group. There was no significant difference between the etiological groups in term of mean age at ESES onset, mean interval between the first seizure and the onset of ESES. The mean age at seizure onset was earlier in the symptomatic/structural group than the idiopathic ones. The mean follow-up time after the ESES onset was 4.5 years for all patients. The most effective antiepileptic drugs in our series were clobazam and levetiracetam. In refractory patients, steroid treatment was found effective during the early course of the disease. In the idiopathic group, cognitive decline has improved. However in the symptomatic group, patients did not respond to the treatment and cognitive deterioration did not improve in one third of the group. CONCLUSION: The long-term outcome of ESES is highly variable and usually depends on etiology and the duration of ESES. The most efficious antiepileptic drugs in our study are clobazam and levetiracetam. SN - 1532-2688 UR - https://www.unboundmedicine.com/medline/citation/25799908/Epileptic_encephalopathy_with_electrical_status_epilepticus:_an_electroclinical_study_of_59_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1059-1311(15)00009-6 DB - PRIME DP - Unbound Medicine ER -