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Association between respiratory viruses and exacerbation of COPD: a case-control study.
Infect Dis (Lond) 2015; 47(8):523-9ID

Abstract

BACKGROUND

Respiratory viral infection is the main cause of exacerbations of chronic obstructive pulmonary disease (COPD) in all age groups. The present study aimed to find out the association between viral infection in exacerbated and stable patients with COPD as well as evaluating the frequency of respiratory viruses in the Iranian exacerbated patients.

METHODS

The study included 170 patients as the sample group with acute exacerbations and a control group consisting of 96 stable patients over a period of 3 years. Reverse transcription- nested polymerase chain reaction (RT-nested PCR) and nested PCR methods were used to diagnose the presence of 16 respiratory viruses.

RESULTS

Viral infection was detected in 81 (47.6%) exacerbations and 24 (25%) stable patients (p < 0.05). Adenovirus was more frequent among the exacerbated patients than the stable patients (p < 0.05). Furthermore, influenza virus, respiratory syncytial virus, and enterovirus turned out to be the most common viruses in both groups. Moreover, respiratory viral co-infection has a possible role in exacerbation, severity, and longer hospitalization. Muscle pain and fever were found as significant symptoms in the infected patients with exacerbations.

CONCLUSIONS

The current study investigated the probable roles of the respiratory viruses, and dual infections during acute exacerbations of COPD. Since climate-dependent respiratory viral incidence patterns in Iran are often dissimilar, preparing a comprehensive global model of respiratory infections with seasonal details in different geographical zones might decrease the morbidity and mortality rate in exacerbations of COPD.

Authors+Show Affiliations

From the Department of Microbiology, North Tehran Branch, Islamic Azad University , Tehran , Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25800059

Citation

Hosseini, Seyedeh Somayeh, et al. "Association Between Respiratory Viruses and Exacerbation of COPD: a Case-control Study." Infectious Diseases (London, England), vol. 47, no. 8, 2015, pp. 523-9.
Hosseini SS, Ghasemian E, Jamaati H, et al. Association between respiratory viruses and exacerbation of COPD: a case-control study. Infect Dis (Lond). 2015;47(8):523-9.
Hosseini, S. S., Ghasemian, E., Jamaati, H., Tabaraie, B., Amini, Z., & Cox, K. (2015). Association between respiratory viruses and exacerbation of COPD: a case-control study. Infectious Diseases (London, England), 47(8), pp. 523-9. doi:10.3109/23744235.2015.1022873.
Hosseini SS, et al. Association Between Respiratory Viruses and Exacerbation of COPD: a Case-control Study. Infect Dis (Lond). 2015;47(8):523-9. PubMed PMID: 25800059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between respiratory viruses and exacerbation of COPD: a case-control study. AU - Hosseini,Seyedeh Somayeh, AU - Ghasemian,Ehsan, AU - Jamaati,Hamidreza, AU - Tabaraie,Bahman, AU - Amini,Zeynab, AU - Cox,Kelsey, Y1 - 2015/03/24/ PY - 2015/3/25/entrez PY - 2015/3/25/pubmed PY - 2016/4/30/medline KW - Iran KW - Viral infection KW - adenovirus KW - polymerase chain reaction SP - 523 EP - 9 JF - Infectious diseases (London, England) JO - Infect Dis (Lond) VL - 47 IS - 8 N2 - BACKGROUND: Respiratory viral infection is the main cause of exacerbations of chronic obstructive pulmonary disease (COPD) in all age groups. The present study aimed to find out the association between viral infection in exacerbated and stable patients with COPD as well as evaluating the frequency of respiratory viruses in the Iranian exacerbated patients. METHODS: The study included 170 patients as the sample group with acute exacerbations and a control group consisting of 96 stable patients over a period of 3 years. Reverse transcription- nested polymerase chain reaction (RT-nested PCR) and nested PCR methods were used to diagnose the presence of 16 respiratory viruses. RESULTS: Viral infection was detected in 81 (47.6%) exacerbations and 24 (25%) stable patients (p < 0.05). Adenovirus was more frequent among the exacerbated patients than the stable patients (p < 0.05). Furthermore, influenza virus, respiratory syncytial virus, and enterovirus turned out to be the most common viruses in both groups. Moreover, respiratory viral co-infection has a possible role in exacerbation, severity, and longer hospitalization. Muscle pain and fever were found as significant symptoms in the infected patients with exacerbations. CONCLUSIONS: The current study investigated the probable roles of the respiratory viruses, and dual infections during acute exacerbations of COPD. Since climate-dependent respiratory viral incidence patterns in Iran are often dissimilar, preparing a comprehensive global model of respiratory infections with seasonal details in different geographical zones might decrease the morbidity and mortality rate in exacerbations of COPD. SN - 2374-4243 UR - https://www.unboundmedicine.com/medline/citation/25800059/Association_between_respiratory_viruses_and_exacerbation_of_COPD:_a_case_control_study_ L2 - http://www.tandfonline.com/doi/abs/10.3109/23744235.2015.1022873 DB - PRIME DP - Unbound Medicine ER -