Tags

Type your tag names separated by a space and hit enter

Prenatal maternal stress predicts stress reactivity at 2½ years of age: the Iowa Flood Study.
Psychoneuroendocrinology. 2015 Jun; 56:62-78.P

Abstract

Prenatal maternal stress (PNMS) predicts psychosocial development in offspring. It has been hypothesized that during PNMS, glucocorticoids pass the placenta, reaching the foetus, leading to a long-term reprogramming and dysregulation of the foetal hypothalamic-pituitary-adrenal (HPA) axis. However, results are inconsistent across PNMS studies. One problem may be the confounding of objective degrees of hardship due to the stressor and subjective degrees of distress in the mother. The present study investigated the association between objective and subjective PNMS due to a natural disaster, the June 2008 Iowa floods, and stress reactivity in the offspring at 2½ years of age. Women who were pregnant during the floods were recruited, on average, within three months of the floods and their stress levels assessed. Mothers and their toddlers (n = 94 dyads) participated in a brief mother-toddler separation to induce physiological stress responses in the offspring. Salivary cortisol samples were collected four times during the procedure. We computed absolute change in cortisol (baseline to 20-minute post-stressor; baseline to 45-minute post-stressor) and Area Under the Curve with respect to increase and ground (AUCi; AUCg). Objective and subjective PNMS were positively correlated with AUCi, as was timing in gestation: the later in pregnancy the exposure occurred, the greater the cortisol increase. Controlling for objective hardship and other covariates, sex-by-subjective PNMS interactions showed a significant and positive association between subjective PNMS and Absolute Increase (45 min) and AUCi in females only, with little effect in males. These results suggest that PNMS leads to long-term alterations in the functioning of the HPA axis, evident as early as 30-months of age.

Authors+Show Affiliations

Psychosocial Research Division, Douglas Mental Health University Institute, Verdun, QC, Canada.Psychosocial Research Division, Douglas Mental Health University Institute, Verdun, QC, Canada.Psychosocial Research Division, Douglas Mental Health University Institute, Verdun, QC, Canada.Department of Obstetrics and Gynaecology, Salzburger Landeskrankenhaus (SALK), Paracelsus Medical University, Salzburg, Austria.Psychosocial Research Division, Douglas Mental Health University Institute, Verdun, QC, Canada; Department of Psychiatry, McGill University, Montreal, QC, Canada.Department of Psychology, University of Iowa, Iowa City, IA, United States.Psychosocial Research Division, Douglas Mental Health University Institute, Verdun, QC, Canada; Department of Psychiatry, McGill University, Montreal, QC, Canada. Electronic address: suzanne.king@mcgill.ca.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25800150

Citation

Yong Ping, Erin, et al. "Prenatal Maternal Stress Predicts Stress Reactivity at 2½ Years of Age: the Iowa Flood Study." Psychoneuroendocrinology, vol. 56, 2015, pp. 62-78.
Yong Ping E, Laplante DP, Elgbeili G, et al. Prenatal maternal stress predicts stress reactivity at 2½ years of age: the Iowa Flood Study. Psychoneuroendocrinology. 2015;56:62-78.
Yong Ping, E., Laplante, D. P., Elgbeili, G., Hillerer, K. M., Brunet, A., O'Hara, M. W., & King, S. (2015). Prenatal maternal stress predicts stress reactivity at 2½ years of age: the Iowa Flood Study. Psychoneuroendocrinology, 56, 62-78. https://doi.org/10.1016/j.psyneuen.2015.02.015
Yong Ping E, et al. Prenatal Maternal Stress Predicts Stress Reactivity at 2½ Years of Age: the Iowa Flood Study. Psychoneuroendocrinology. 2015;56:62-78. PubMed PMID: 25800150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal maternal stress predicts stress reactivity at 2½ years of age: the Iowa Flood Study. AU - Yong Ping,Erin, AU - Laplante,David P, AU - Elgbeili,Guillaume, AU - Hillerer,Katharina M, AU - Brunet,Alain, AU - O'Hara,Michael W, AU - King,Suzanne, Y1 - 2015/03/02/ PY - 2014/10/15/received PY - 2015/02/19/revised PY - 2015/02/20/accepted PY - 2015/3/25/entrez PY - 2015/3/25/pubmed PY - 2016/1/6/medline KW - Child development KW - Cortisol reactivity KW - Cortisol stress response KW - HPA axis KW - Prenatal stress SP - 62 EP - 78 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 56 N2 - Prenatal maternal stress (PNMS) predicts psychosocial development in offspring. It has been hypothesized that during PNMS, glucocorticoids pass the placenta, reaching the foetus, leading to a long-term reprogramming and dysregulation of the foetal hypothalamic-pituitary-adrenal (HPA) axis. However, results are inconsistent across PNMS studies. One problem may be the confounding of objective degrees of hardship due to the stressor and subjective degrees of distress in the mother. The present study investigated the association between objective and subjective PNMS due to a natural disaster, the June 2008 Iowa floods, and stress reactivity in the offspring at 2½ years of age. Women who were pregnant during the floods were recruited, on average, within three months of the floods and their stress levels assessed. Mothers and their toddlers (n = 94 dyads) participated in a brief mother-toddler separation to induce physiological stress responses in the offspring. Salivary cortisol samples were collected four times during the procedure. We computed absolute change in cortisol (baseline to 20-minute post-stressor; baseline to 45-minute post-stressor) and Area Under the Curve with respect to increase and ground (AUCi; AUCg). Objective and subjective PNMS were positively correlated with AUCi, as was timing in gestation: the later in pregnancy the exposure occurred, the greater the cortisol increase. Controlling for objective hardship and other covariates, sex-by-subjective PNMS interactions showed a significant and positive association between subjective PNMS and Absolute Increase (45 min) and AUCi in females only, with little effect in males. These results suggest that PNMS leads to long-term alterations in the functioning of the HPA axis, evident as early as 30-months of age. SN - 1873-3360 UR - https://www.unboundmedicine.com/medline/citation/25800150/Prenatal_maternal_stress_predicts_stress_reactivity_at_2½_years_of_age:_the_Iowa_Flood_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(15)00076-1 DB - PRIME DP - Unbound Medicine ER -