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Health-related quality of life of Asian patients with end-stage renal disease (ESRD) in Singapore.
Qual Life Res. 2015 Sep; 24(9):2163-71.QL

Abstract

BACKGROUND

This study aimed to identify factors associated with the health-related quality of life (HRQOL) of multiethnic Asian end-stage renal disease (ESRD) patients treated with dialysis. The role of dialysis modality was also explored.

METHODS

Data used in this study were from two cross-sectional surveys of Singaporean ESRD patients on haemodialysis (HD) or peritoneal dialysis (PD). In both surveys, participants were assessed using the kidney disease quality of life (KDQOL) instrument and questions assessing socio-demographic characteristics. Clinical data including co-morbidity (measured by Charlson comorbidity index [CCI]), albumin level, haemoglobin level, and dialysis-related variables (e.g. dialysis vintage and dialysis adequacy) were retrieved from medical records. The 36-item KDQOL (KDQOL-36) was used to generate three summary scores (physical component summary [PCS], mental component summary [MCS] and kidney disease component summary [KDCS]) and two health utility scores (Short Form 6-dimension [SF-6D] and EuroQol 5-dimension [EQ-5D]). Linear regression analysis was performed to examine the association of factors with each of the HRQOL scale scores.

RESULTS

Five hundred and two patients were included in the study (mean age 57.1 years; male 52.4 %; HD 236, PD 266). Mean [standard deviation (SD)] PCS, MCS and KDCS scores were 37.9 (9.7), 46.4 (10.8) and 57.6 (18.1), respectively. Mean (SD) health utility score was 0.66 (0.12) for SF-6D and 0.60 (0.21) for EQ-5D. In multivariate regression analysis, factors found to be significantly associated with better HRQOL included: young (<45 years) or old age (>60 years), low CCI (<5), high albumin (≥37 g/l) and high haemoglobin (≥11 g/dl) with PCS; long dialysis vintage (≥3.5 years) with MCS; old age, Malay ethnicity and PD modality with KDCS; low CCI, high albumin and high haemoglobin with EQ-5D and high albumin with SF-6D.

CONCLUSIONS

Clinical characteristics are better predictors of HRQOL in ESRD patients than socio-demographics in Singapore. Dialysis modality has no impact on the health utility of those patients.

Authors+Show Affiliations

Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, Singapore, 117549, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25800727

Citation

Yang, F, et al. "Health-related Quality of Life of Asian Patients With End-stage Renal Disease (ESRD) in Singapore." Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, vol. 24, no. 9, 2015, pp. 2163-71.
Yang F, Griva K, Lau T, et al. Health-related quality of life of Asian patients with end-stage renal disease (ESRD) in Singapore. Qual Life Res. 2015;24(9):2163-71.
Yang, F., Griva, K., Lau, T., Vathsala, A., Lee, E., Ng, H. J., Mooppil, N., Foo, M., Newman, S. P., Chia, K. S., & Luo, N. (2015). Health-related quality of life of Asian patients with end-stage renal disease (ESRD) in Singapore. Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 24(9), 2163-71. https://doi.org/10.1007/s11136-015-0964-0
Yang F, et al. Health-related Quality of Life of Asian Patients With End-stage Renal Disease (ESRD) in Singapore. Qual Life Res. 2015;24(9):2163-71. PubMed PMID: 25800727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Health-related quality of life of Asian patients with end-stage renal disease (ESRD) in Singapore. AU - Yang,F, AU - Griva,K, AU - Lau,T, AU - Vathsala,A, AU - Lee,E, AU - Ng,H J, AU - Mooppil,N, AU - Foo,M, AU - Newman,S P, AU - Chia,K S, AU - Luo,N, Y1 - 2015/03/24/ PY - 2015/03/03/accepted PY - 2015/3/25/entrez PY - 2015/3/25/pubmed PY - 2016/3/5/medline SP - 2163 EP - 71 JF - Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation JO - Qual Life Res VL - 24 IS - 9 N2 - BACKGROUND: This study aimed to identify factors associated with the health-related quality of life (HRQOL) of multiethnic Asian end-stage renal disease (ESRD) patients treated with dialysis. The role of dialysis modality was also explored. METHODS: Data used in this study were from two cross-sectional surveys of Singaporean ESRD patients on haemodialysis (HD) or peritoneal dialysis (PD). In both surveys, participants were assessed using the kidney disease quality of life (KDQOL) instrument and questions assessing socio-demographic characteristics. Clinical data including co-morbidity (measured by Charlson comorbidity index [CCI]), albumin level, haemoglobin level, and dialysis-related variables (e.g. dialysis vintage and dialysis adequacy) were retrieved from medical records. The 36-item KDQOL (KDQOL-36) was used to generate three summary scores (physical component summary [PCS], mental component summary [MCS] and kidney disease component summary [KDCS]) and two health utility scores (Short Form 6-dimension [SF-6D] and EuroQol 5-dimension [EQ-5D]). Linear regression analysis was performed to examine the association of factors with each of the HRQOL scale scores. RESULTS: Five hundred and two patients were included in the study (mean age 57.1 years; male 52.4 %; HD 236, PD 266). Mean [standard deviation (SD)] PCS, MCS and KDCS scores were 37.9 (9.7), 46.4 (10.8) and 57.6 (18.1), respectively. Mean (SD) health utility score was 0.66 (0.12) for SF-6D and 0.60 (0.21) for EQ-5D. In multivariate regression analysis, factors found to be significantly associated with better HRQOL included: young (<45 years) or old age (>60 years), low CCI (<5), high albumin (≥37 g/l) and high haemoglobin (≥11 g/dl) with PCS; long dialysis vintage (≥3.5 years) with MCS; old age, Malay ethnicity and PD modality with KDCS; low CCI, high albumin and high haemoglobin with EQ-5D and high albumin with SF-6D. CONCLUSIONS: Clinical characteristics are better predictors of HRQOL in ESRD patients than socio-demographics in Singapore. Dialysis modality has no impact on the health utility of those patients. SN - 1573-2649 UR - https://www.unboundmedicine.com/medline/citation/25800727/Health_related_quality_of_life_of_Asian_patients_with_end_stage_renal_disease__ESRD__in_Singapore_ L2 - https://doi.org/10.1007/s11136-015-0964-0 DB - PRIME DP - Unbound Medicine ER -