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Analysis of the contributing factors to airway hyperresponsiveness by a forced oscillation technique in patients with asthma.
Osaka City Med J. 2014 Dec; 60(2):53-62.OC

Abstract

BACKGROUND

Forced oscillation technique (FOT) is increasingly used to obtain much information on the state of the respiratory system. However, there are little data about FOT parameters on methacholine provocation test in adult asthma. This study was designed to determine the physiological implications of FOT parameters during methacholine provocation and analyze the major contributing factors to airway hyperresponsiveness (AHR) in asthma.

METHODS

Spirometry and FOT were performed in 22 asthmatic patients and 21 normal control subjects before and after provocation with a maximal dose of methacholine.

RESULTS

In asthmatic patients, the percent increase in resistance at 5 Hz (R5) and resistance at 20 Hz (R20) after the methacholine provocation was 70 [45-93] % and 16 [5-23] %. The percent change in R20 was not significantly correlated with the percent change in FVC or FEV1. Similarly, the percent change in R5 was not significantly correlated with the percent change in FEV1, but was significantly correlated with the percent change in FVC. Moreover, the percent change in R5 was significantly correlated with the closing index (r = 0.55, p = 0.01). In addition, AHR to methacholine was closely correlated with the percent change in R5 (r = -0.71, p = 0.001).

CONCLUSIONS

Simultaneous measurement of FOT and bronchial challenge test provide meaningful information, and greater change in R5 may represent exaggerated response of small airways in asthmatic patients. This study will provide new insights into the physiological implications of each FOT parameter in asthmatic patients.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25803880

Citation

Imahashi, Yumiko, et al. "Analysis of the Contributing Factors to Airway Hyperresponsiveness By a Forced Oscillation Technique in Patients With Asthma." Osaka City Medical Journal, vol. 60, no. 2, 2014, pp. 53-62.
Imahashi Y, Kanazawa H, Ijiri N, et al. Analysis of the contributing factors to airway hyperresponsiveness by a forced oscillation technique in patients with asthma. Osaka City Med J. 2014;60(2):53-62.
Imahashi, Y., Kanazawa, H., Ijiri, N., Yoshii, N., Tamagaki, G., Asai, K., Tochino, Y., & Hirata, K. (2014). Analysis of the contributing factors to airway hyperresponsiveness by a forced oscillation technique in patients with asthma. Osaka City Medical Journal, 60(2), 53-62.
Imahashi Y, et al. Analysis of the Contributing Factors to Airway Hyperresponsiveness By a Forced Oscillation Technique in Patients With Asthma. Osaka City Med J. 2014;60(2):53-62. PubMed PMID: 25803880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of the contributing factors to airway hyperresponsiveness by a forced oscillation technique in patients with asthma. AU - Imahashi,Yumiko, AU - Kanazawa,Hiroshi, AU - Ijiri,Naoki, AU - Yoshii,Naoko, AU - Tamagaki,Gakuya, AU - Asai,Kazuhisa, AU - Tochino,Yoshihiro, AU - Hirata,Kazuto, PY - 2015/3/26/entrez PY - 2015/3/26/pubmed PY - 2015/5/1/medline SP - 53 EP - 62 JF - Osaka city medical journal JO - Osaka City Med J VL - 60 IS - 2 N2 - BACKGROUND: Forced oscillation technique (FOT) is increasingly used to obtain much information on the state of the respiratory system. However, there are little data about FOT parameters on methacholine provocation test in adult asthma. This study was designed to determine the physiological implications of FOT parameters during methacholine provocation and analyze the major contributing factors to airway hyperresponsiveness (AHR) in asthma. METHODS: Spirometry and FOT were performed in 22 asthmatic patients and 21 normal control subjects before and after provocation with a maximal dose of methacholine. RESULTS: In asthmatic patients, the percent increase in resistance at 5 Hz (R5) and resistance at 20 Hz (R20) after the methacholine provocation was 70 [45-93] % and 16 [5-23] %. The percent change in R20 was not significantly correlated with the percent change in FVC or FEV1. Similarly, the percent change in R5 was not significantly correlated with the percent change in FEV1, but was significantly correlated with the percent change in FVC. Moreover, the percent change in R5 was significantly correlated with the closing index (r = 0.55, p = 0.01). In addition, AHR to methacholine was closely correlated with the percent change in R5 (r = -0.71, p = 0.001). CONCLUSIONS: Simultaneous measurement of FOT and bronchial challenge test provide meaningful information, and greater change in R5 may represent exaggerated response of small airways in asthmatic patients. This study will provide new insights into the physiological implications of each FOT parameter in asthmatic patients. SN - 0030-6096 UR - https://www.unboundmedicine.com/medline/citation/25803880/Analysis_of_the_contributing_factors_to_airway_hyperresponsiveness_by_a_forced_oscillation_technique_in_patients_with_asthma_ L2 - http://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -