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Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome (AIDS). Diagnosis with bronchial brushings, biopsy, and bronchoalveolar lavage.
Chest. 1985 May; 87(5):603-7.Chest

Abstract

Sixty-one diagnostic biopsies for Pneumocystis carinii pneumonia were performed on 40 homosexual male patients with acquired immunodeficiency syndrome (AIDS), using flexible fiberoptic bronchoscopy. Bronchial brushings and bronchoalveolar lavage were performed in conjunction with the biopsy in 58 and 29 bronchoscopies, respectively. Using a rapid methenamine silver stain, P carinii pneumonia was diagnosed in 27 (68 percent) of the patients. Twenty of these patients had a repeat biopsy one or more times for evaluation of therapy. Eighteen of the biopsies following two to three weeks of therapy were positive. There was an 84 percent correlation between findings on transbronchial brushing and biopsy (89 percent on initial biopsy before treatment) and an 86 percent correlation between bronchoalveolar lavage and biopsy. Additionally, transbronchial brushing permitted demonstration of Pneumocystis organisms in four follow-up bronchoscopies in which the biopsy was negative or inadequate. Rapid methenamine silver stain of transbronchial brushings permits diagnosis of P carinii pneumonia in patients with AIDS within one-half hour of bronchoscopy.

Authors

Hartman B
No affiliation info available
Koss M
No affiliation info available
Hui A
No affiliation info available
Baumann W
No affiliation info available
Athos L
No affiliation info available
Boylen T
No affiliation info available

MeSH

Acquired Immunodeficiency SyndromeAdultBiopsyBronchiBronchoscopyHomosexualityHumansLungMaleMiddle AgedPneumonia, PneumocystisPulmonary AlveoliSilverStaining and LabelingTherapeutic Irrigation

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2580669

Citation

Hartman, B, et al. "Pneumocystis Carinii Pneumonia in the Acquired Immunodeficiency Syndrome (AIDS). Diagnosis With Bronchial Brushings, Biopsy, and Bronchoalveolar Lavage." Chest, vol. 87, no. 5, 1985, pp. 603-7.
Hartman B, Koss M, Hui A, et al. Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome (AIDS). Diagnosis with bronchial brushings, biopsy, and bronchoalveolar lavage. Chest. 1985;87(5):603-7.
Hartman, B., Koss, M., Hui, A., Baumann, W., Athos, L., & Boylen, T. (1985). Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome (AIDS). Diagnosis with bronchial brushings, biopsy, and bronchoalveolar lavage. Chest, 87(5), 603-7.
Hartman B, et al. Pneumocystis Carinii Pneumonia in the Acquired Immunodeficiency Syndrome (AIDS). Diagnosis With Bronchial Brushings, Biopsy, and Bronchoalveolar Lavage. Chest. 1985;87(5):603-7. PubMed PMID: 2580669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome (AIDS). Diagnosis with bronchial brushings, biopsy, and bronchoalveolar lavage. AU - Hartman,B, AU - Koss,M, AU - Hui,A, AU - Baumann,W, AU - Athos,L, AU - Boylen,T, PY - 1985/5/1/pubmed PY - 1985/5/1/medline PY - 1985/5/1/entrez SP - 603 EP - 7 JF - Chest JO - Chest VL - 87 IS - 5 N2 - Sixty-one diagnostic biopsies for Pneumocystis carinii pneumonia were performed on 40 homosexual male patients with acquired immunodeficiency syndrome (AIDS), using flexible fiberoptic bronchoscopy. Bronchial brushings and bronchoalveolar lavage were performed in conjunction with the biopsy in 58 and 29 bronchoscopies, respectively. Using a rapid methenamine silver stain, P carinii pneumonia was diagnosed in 27 (68 percent) of the patients. Twenty of these patients had a repeat biopsy one or more times for evaluation of therapy. Eighteen of the biopsies following two to three weeks of therapy were positive. There was an 84 percent correlation between findings on transbronchial brushing and biopsy (89 percent on initial biopsy before treatment) and an 86 percent correlation between bronchoalveolar lavage and biopsy. Additionally, transbronchial brushing permitted demonstration of Pneumocystis organisms in four follow-up bronchoscopies in which the biopsy was negative or inadequate. Rapid methenamine silver stain of transbronchial brushings permits diagnosis of P carinii pneumonia in patients with AIDS within one-half hour of bronchoscopy. SN - 0012-3692 UR - https://www.unboundmedicine.com/medline/citation/2580669/Pneumocystis_carinii_pneumonia_in_the_acquired_immunodeficiency_syndrome__AIDS___Diagnosis_with_bronchial_brushings_biopsy_and_bronchoalveolar_lavage_ DB - PRIME DP - Unbound Medicine ER -