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Migraine and risk of ischaemic heart disease: a systematic review and meta-analysis of observational studies.

Abstract

BACKGROUND AND PURPOSE

Several studies have assessed the risk of ischaemic heart diseases in migraineurs, drawing different conclusions. To define and update the issue, a systematic review and meta-analysis of the available observational studies was performed.

METHODS

PubMed and EMBASE were systematically searched up to April 2014 for observational studies dealing with the risk of any form of ischaemic heart disease in migraineurs. Studies assessing migraine as exposure and several types of ischaemic heart disease as outcomes were included in the analysis. A random effects model was used to pool the effect sizes.

RESULTS

Out of 3348 records, 15 studies (one case-control, one cross-sectional and 13 cohort studies) were identified and were included in the meta-analysis. The pooled analysis indicated an increased risk of myocardial infarction (pooled adjusted effect estimate 1.33, 95% confidence interval 1.08-1.64; P = 0.007) and of angina (pooled adjusted effect estimate 1.29, 95% confidence interval 1.17-1.43; P < 0.0001) in migraineurs compared to non-migraineurs.

CONCLUSIONS

Based on our data indicating an association of migraine with myocardial infarction and angina and on previous data showing an association of migraine, and particularly migraine with aura, with an increased risk for stroke, migraine can be appropriately considered an overall risk factor for cardiovascular diseases.

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  • Authors+Show Affiliations

    ,

    Department of Applied Clinical Sciences and Biotechnology, Institute of Neurology, University of L'Aquila, L'Aquila, Italy.

    , , , , ,

    Source

    European journal of neurology 22:6 2015 Jun pg 1001-11

    MeSH

    Angina Pectoris
    Comorbidity
    Humans
    Migraine Disorders
    Myocardial Infarction

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    25808832

    Citation

    Sacco, S, et al. "Migraine and Risk of Ischaemic Heart Disease: a Systematic Review and Meta-analysis of Observational Studies." European Journal of Neurology, vol. 22, no. 6, 2015, pp. 1001-11.
    Sacco S, Ornello R, Ripa P, et al. Migraine and risk of ischaemic heart disease: a systematic review and meta-analysis of observational studies. Eur J Neurol. 2015;22(6):1001-11.
    Sacco, S., Ornello, R., Ripa, P., Tiseo, C., Degan, D., Pistoia, F., & Carolei, A. (2015). Migraine and risk of ischaemic heart disease: a systematic review and meta-analysis of observational studies. European Journal of Neurology, 22(6), pp. 1001-11. doi:10.1111/ene.12701.
    Sacco S, et al. Migraine and Risk of Ischaemic Heart Disease: a Systematic Review and Meta-analysis of Observational Studies. Eur J Neurol. 2015;22(6):1001-11. PubMed PMID: 25808832.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Migraine and risk of ischaemic heart disease: a systematic review and meta-analysis of observational studies. AU - Sacco,S, AU - Ornello,R, AU - Ripa,P, AU - Tiseo,C, AU - Degan,D, AU - Pistoia,F, AU - Carolei,A, Y1 - 2015/03/25/ PY - 2014/10/28/received PY - 2015/02/06/accepted PY - 2015/3/27/entrez PY - 2015/3/27/pubmed PY - 2015/12/23/medline KW - cardiovascular disease KW - headache disorders KW - ischaemic heart disease KW - meta-analysis KW - migraine SP - 1001 EP - 11 JF - European journal of neurology JO - Eur. J. Neurol. VL - 22 IS - 6 N2 - BACKGROUND AND PURPOSE: Several studies have assessed the risk of ischaemic heart diseases in migraineurs, drawing different conclusions. To define and update the issue, a systematic review and meta-analysis of the available observational studies was performed. METHODS: PubMed and EMBASE were systematically searched up to April 2014 for observational studies dealing with the risk of any form of ischaemic heart disease in migraineurs. Studies assessing migraine as exposure and several types of ischaemic heart disease as outcomes were included in the analysis. A random effects model was used to pool the effect sizes. RESULTS: Out of 3348 records, 15 studies (one case-control, one cross-sectional and 13 cohort studies) were identified and were included in the meta-analysis. The pooled analysis indicated an increased risk of myocardial infarction (pooled adjusted effect estimate 1.33, 95% confidence interval 1.08-1.64; P = 0.007) and of angina (pooled adjusted effect estimate 1.29, 95% confidence interval 1.17-1.43; P < 0.0001) in migraineurs compared to non-migraineurs. CONCLUSIONS: Based on our data indicating an association of migraine with myocardial infarction and angina and on previous data showing an association of migraine, and particularly migraine with aura, with an increased risk for stroke, migraine can be appropriately considered an overall risk factor for cardiovascular diseases. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/25808832/Migraine_and_risk_of_ischaemic_heart_disease:_a_systematic_review_and_meta_analysis_of_observational_studies_ L2 - https://doi.org/10.1111/ene.12701 DB - PRIME DP - Unbound Medicine ER -