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Oxidative damage of naphthenic acids on the Eisenia fetida earthworm.
Environ Toxicol. 2016 Nov; 31(11):1337-1343.ET

Abstract

Naphthenic acids (NAs) have been gaining recognition in recent years as potentially harmful environmental contaminants. Few studies have focused on the potential ecotoxicity of NAs to terrestrial environment. In this study, the responses of antioxidant system and lipid peroxidation and DNA damage were investigated after exposing Eisenia fetida to soil contaminated with NAs. The results indicated that NAs induced a significant increase (p < 0.05) in superoxide dismutase and catalase enzyme activities. The glutathione peroxidase enzyme activities were significantly inhibited (p < 0.05) in the medium and high dose treatments. An increase in malondialidehyde indicated that NAs could cause cellular lipid peroxidation in the tested earthworms. The percentage of DNA in the tail of comet assay of coelomocytes as an indication of DNA damage increased after treatment with different doses of NAs, and a dose-dependent DNA damage of coelomocytes was found. In conclusion, oxidative stress caused by NAs exposure induces physiological responses and genotoxicity on earthworms. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1337-1343, 2016.

Authors+Show Affiliations

State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China. yhuang@pku.edu.cn.State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25809073

Citation

Wang, Jie, et al. "Oxidative Damage of Naphthenic Acids On the Eisenia Fetida Earthworm." Environmental Toxicology, vol. 31, no. 11, 2016, pp. 1337-1343.
Wang J, Cao X, Chai L, et al. Oxidative damage of naphthenic acids on the Eisenia fetida earthworm. Environ Toxicol. 2016;31(11):1337-1343.
Wang, J., Cao, X., Chai, L., Liao, J., Huang, Y., & Tang, X. (2016). Oxidative damage of naphthenic acids on the Eisenia fetida earthworm. Environmental Toxicology, 31(11), 1337-1343. https://doi.org/10.1002/tox.22139
Wang J, et al. Oxidative Damage of Naphthenic Acids On the Eisenia Fetida Earthworm. Environ Toxicol. 2016;31(11):1337-1343. PubMed PMID: 25809073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative damage of naphthenic acids on the Eisenia fetida earthworm. AU - Wang,Jie, AU - Cao,Xiaofeng, AU - Chai,Liwei, AU - Liao,Jingqiu, AU - Huang,Yi, AU - Tang,Xiaoyan, Y1 - 2015/03/24/ PY - 2014/10/21/received PY - 2015/02/16/revised PY - 2015/03/07/accepted PY - 2016/10/19/pubmed PY - 2017/3/3/medline PY - 2015/3/27/entrez KW - antioxidant enzyme KW - genotoxicity KW - lipid peroxidation KW - naphthenic acids KW - oxidative stress SP - 1337 EP - 1343 JF - Environmental toxicology JO - Environ Toxicol VL - 31 IS - 11 N2 - Naphthenic acids (NAs) have been gaining recognition in recent years as potentially harmful environmental contaminants. Few studies have focused on the potential ecotoxicity of NAs to terrestrial environment. In this study, the responses of antioxidant system and lipid peroxidation and DNA damage were investigated after exposing Eisenia fetida to soil contaminated with NAs. The results indicated that NAs induced a significant increase (p < 0.05) in superoxide dismutase and catalase enzyme activities. The glutathione peroxidase enzyme activities were significantly inhibited (p < 0.05) in the medium and high dose treatments. An increase in malondialidehyde indicated that NAs could cause cellular lipid peroxidation in the tested earthworms. The percentage of DNA in the tail of comet assay of coelomocytes as an indication of DNA damage increased after treatment with different doses of NAs, and a dose-dependent DNA damage of coelomocytes was found. In conclusion, oxidative stress caused by NAs exposure induces physiological responses and genotoxicity on earthworms. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1337-1343, 2016. SN - 1522-7278 UR - https://www.unboundmedicine.com/medline/citation/25809073/Oxidative_damage_of_naphthenic_acids_on_the_Eisenia_fetida_earthworm_ L2 - https://doi.org/10.1002/tox.22139 DB - PRIME DP - Unbound Medicine ER -