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Persistence of pathological distribution of NK cells in HIV-infected patients with prolonged use of HAART and a sustained immune response.
PLoS One 2015; 10(3):e0121019Plos

Abstract

OBJECTIVE

A prospective analysis of the distribution of NK subsets and natural cytotoxicity receptors (NKp30/NKp46) in HIV patients with long-term HAART use and sustained virological and immunological response.

METHODS

The main inclusion criteria were: at least 3 years' receipt of HAART; current CD4+ count ≥ 500 cells/mm3; undetectable viral load for at least 24 months; no hepatotropic virus co-infection. Percentages of CD56dim, CD56bright NK cells and CD56neg CD16+ cells were obtained. Expression of the NCRs, NKp30 and NKp46 was analysed in CD56+ cells. Thirty-nine infected patients and sixteen healthy donors were included in the study.

RESULTS

The percentages of total CD56+ and CD56dim NK cells were significantly lower in HIV-infected patients than in healthy donors (70.4 vs. 50.3 and 80.9 vs. 66.1 respectively). The percentage of total CD56+ NK cells expressing NCR receptors was lower in HIV patients than in healthy donors (NKp30: 25.20 vs. 58.63; NKp46: 24.8 vs. 50.59). This was also observed for CD56dim and CD56bright NK cells. Length of time with undetectable HIV viral load was identified as an independent factor associated with higher expression of NKp30 and NKp46.

CONCLUSION

Despite the prolonged and effective use of HAART, HIV-infected patients do not fully reconstitute the distribution of NK cells. Length of time with an undetectable viral load was related to greater recovery of NKp30/NKp46 receptors.

Authors+Show Affiliations

Infectious Diseases Unit, Hospital Universitario Reina Sofia de Córdoba, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Cordoba, Spain.Infectious Diseases Unit, Hospital Universitario Reina Sofia de Córdoba, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Cordoba, Spain.Infectious Diseases Unit, Hospital Universitario Reina Sofia de Córdoba, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Cordoba, Spain.Infectious Diseases Unit, Hospital Universitario Reina Sofia de Córdoba, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Cordoba, Spain.Infectious Diseases Unit, Hospital Universitario Reina Sofia de Córdoba, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Cordoba, Spain.Infectious Diseases Unit, Hospital Universitario Reina Sofia de Córdoba, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Cordoba, Spain.Infectious Diseases Unit, Hospital Universitario Reina Sofia de Córdoba, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Cordoba, Spain.Immunology Unit, Hospital Universitario Reina Sofia de Córdoba, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Cordoba, Spain.Infectious Diseases Unit, Hospital Universitario Reina Sofia de Córdoba, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Cordoba, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25811634

Citation

Frias, Mario, et al. "Persistence of Pathological Distribution of NK Cells in HIV-infected Patients With Prolonged Use of HAART and a Sustained Immune Response." PloS One, vol. 10, no. 3, 2015, pp. e0121019.
Frias M, Rivero-Juarez A, Gordon A, et al. Persistence of pathological distribution of NK cells in HIV-infected patients with prolonged use of HAART and a sustained immune response. PLoS ONE. 2015;10(3):e0121019.
Frias, M., Rivero-Juarez, A., Gordon, A., Camacho, A., Cantisan, S., Cuenca-Lopez, F., ... Rivero, A. (2015). Persistence of pathological distribution of NK cells in HIV-infected patients with prolonged use of HAART and a sustained immune response. PloS One, 10(3), pp. e0121019. doi:10.1371/journal.pone.0121019.
Frias M, et al. Persistence of Pathological Distribution of NK Cells in HIV-infected Patients With Prolonged Use of HAART and a Sustained Immune Response. PLoS ONE. 2015;10(3):e0121019. PubMed PMID: 25811634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Persistence of pathological distribution of NK cells in HIV-infected patients with prolonged use of HAART and a sustained immune response. AU - Frias,Mario, AU - Rivero-Juarez,Antonio, AU - Gordon,Ana, AU - Camacho,Angela, AU - Cantisan,Sara, AU - Cuenca-Lopez,Francisca, AU - Torre-Cisneros,Julian, AU - Peña,Jose, AU - Rivero,Antonio, Y1 - 2015/03/26/ PY - 2014/10/15/received PY - 2015/02/09/accepted PY - 2015/3/27/entrez PY - 2015/3/27/pubmed PY - 2016/3/2/medline SP - e0121019 EP - e0121019 JF - PloS one JO - PLoS ONE VL - 10 IS - 3 N2 - OBJECTIVE: A prospective analysis of the distribution of NK subsets and natural cytotoxicity receptors (NKp30/NKp46) in HIV patients with long-term HAART use and sustained virological and immunological response. METHODS: The main inclusion criteria were: at least 3 years' receipt of HAART; current CD4+ count ≥ 500 cells/mm3; undetectable viral load for at least 24 months; no hepatotropic virus co-infection. Percentages of CD56dim, CD56bright NK cells and CD56neg CD16+ cells were obtained. Expression of the NCRs, NKp30 and NKp46 was analysed in CD56+ cells. Thirty-nine infected patients and sixteen healthy donors were included in the study. RESULTS: The percentages of total CD56+ and CD56dim NK cells were significantly lower in HIV-infected patients than in healthy donors (70.4 vs. 50.3 and 80.9 vs. 66.1 respectively). The percentage of total CD56+ NK cells expressing NCR receptors was lower in HIV patients than in healthy donors (NKp30: 25.20 vs. 58.63; NKp46: 24.8 vs. 50.59). This was also observed for CD56dim and CD56bright NK cells. Length of time with undetectable HIV viral load was identified as an independent factor associated with higher expression of NKp30 and NKp46. CONCLUSION: Despite the prolonged and effective use of HAART, HIV-infected patients do not fully reconstitute the distribution of NK cells. Length of time with an undetectable viral load was related to greater recovery of NKp30/NKp46 receptors. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25811634/Persistence_of_pathological_distribution_of_NK_cells_in_HIV_infected_patients_with_prolonged_use_of_HAART_and_a_sustained_immune_response_ L2 - http://dx.plos.org/10.1371/journal.pone.0121019 DB - PRIME DP - Unbound Medicine ER -