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Association of Parkinson's Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case-Control Study in France.
Environ Health Perspect. 2015 Nov; 123(11):1123-9.EH

Abstract

BACKGROUND

Pesticides have been associated with Parkinson's disease (PD), but there are few data on important exposure characteristics such as dose-effect relations. It is unknown whether associations depend on clinical PD subtypes.

OBJECTIVES

We examined quantitative aspects of occupational pesticide exposure associated with PD and investigated whether associations were similar across PD subtypes.

METHODS

As part of a French population-based case-control study including men enrolled in the health insurance plan for farmers and agricultural workers, cases with clinically confirmed PD were identified through antiparkinsonian drug claims. Two controls were matched to each case. Using a comprehensive occupational questionnaire, we computed indicators for different dimensions of exposure (duration, cumulative exposure, intensity). We used conditional logistic regression to compute odds ratios (ORs) and 95% confidence intervals (CIs) among exposed male farmers (133 cases, 298 controls). We examined the relation between pesticides and PD subtypes (tremor dominant/non-tremor dominant) using polytomous logistic regression.

RESULTS

There appeared to be a stronger association with intensity than duration of pesticide exposure based on separate models, as well as a synergistic interaction between duration and intensity (p-interaction = 0.04). High-intensity exposure to insecticides was positively associated with PD among those with low-intensity exposure to fungicides and vice versa, suggesting independent effects. Pesticide exposure in farms that specialized in vineyards was associated with PD (OR = 2.56; 95% CI: 1.31, 4.98). The association with intensity of pesticide use was stronger, although not significantly (p-heterogeneity = 0.60), for tremor-dominant (p-trend < 0.01) than for non-tremor-dominant PD (p-trend = 0.24).

CONCLUSIONS

This study helps to better characterize different aspects of pesticide exposure associated with PD, and shows a significant association of pesticides with tremor-dominant PD in men, the most typical PD presentation.

CITATION

Moisan F, Spinosi J, Delabre L, Gourlet V, Mazurie JL, Bénatru I, Goldberg M, Weisskopf MG, Imbernon E, Tzourio C, Elbaz A. 2015. Association of Parkinson's disease and its subtypes with agricultural pesticide exposures in men: a case-control study in France. Environ Health Perspect 123:1123-1129; http://dx.doi.org/10.1289/ehp.1307970.

Authors+Show Affiliations

Département santé travail, Institut de veille sanitaire, Saint-Maurice, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25815770

Citation

Moisan, Frédéric, et al. "Association of Parkinson's Disease and Its Subtypes With Agricultural Pesticide Exposures in Men: a Case-Control Study in France." Environmental Health Perspectives, vol. 123, no. 11, 2015, pp. 1123-9.
Moisan F, Spinosi J, Delabre L, et al. Association of Parkinson's Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case-Control Study in France. Environ Health Perspect. 2015;123(11):1123-9.
Moisan, F., Spinosi, J., Delabre, L., Gourlet, V., Mazurie, J. L., Bénatru, I., Goldberg, M., Weisskopf, M. G., Imbernon, E., Tzourio, C., & Elbaz, A. (2015). Association of Parkinson's Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case-Control Study in France. Environmental Health Perspectives, 123(11), 1123-9. https://doi.org/10.1289/ehp.1307970
Moisan F, et al. Association of Parkinson's Disease and Its Subtypes With Agricultural Pesticide Exposures in Men: a Case-Control Study in France. Environ Health Perspect. 2015;123(11):1123-9. PubMed PMID: 25815770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Parkinson's Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case-Control Study in France. AU - Moisan,Frédéric, AU - Spinosi,Johan, AU - Delabre,Laurène, AU - Gourlet,Véronique, AU - Mazurie,Jean-Louis, AU - Bénatru,Isabelle, AU - Goldberg,Marcel, AU - Weisskopf,Marc G, AU - Imbernon,Ellen, AU - Tzourio,Christophe, AU - Elbaz,Alexis, Y1 - 2015/03/27/ PY - 2013/12/06/received PY - 2015/03/25/accepted PY - 2015/3/28/entrez PY - 2015/3/31/pubmed PY - 2016/9/27/medline SP - 1123 EP - 9 JF - Environmental health perspectives JO - Environ Health Perspect VL - 123 IS - 11 N2 - BACKGROUND: Pesticides have been associated with Parkinson's disease (PD), but there are few data on important exposure characteristics such as dose-effect relations. It is unknown whether associations depend on clinical PD subtypes. OBJECTIVES: We examined quantitative aspects of occupational pesticide exposure associated with PD and investigated whether associations were similar across PD subtypes. METHODS: As part of a French population-based case-control study including men enrolled in the health insurance plan for farmers and agricultural workers, cases with clinically confirmed PD were identified through antiparkinsonian drug claims. Two controls were matched to each case. Using a comprehensive occupational questionnaire, we computed indicators for different dimensions of exposure (duration, cumulative exposure, intensity). We used conditional logistic regression to compute odds ratios (ORs) and 95% confidence intervals (CIs) among exposed male farmers (133 cases, 298 controls). We examined the relation between pesticides and PD subtypes (tremor dominant/non-tremor dominant) using polytomous logistic regression. RESULTS: There appeared to be a stronger association with intensity than duration of pesticide exposure based on separate models, as well as a synergistic interaction between duration and intensity (p-interaction = 0.04). High-intensity exposure to insecticides was positively associated with PD among those with low-intensity exposure to fungicides and vice versa, suggesting independent effects. Pesticide exposure in farms that specialized in vineyards was associated with PD (OR = 2.56; 95% CI: 1.31, 4.98). The association with intensity of pesticide use was stronger, although not significantly (p-heterogeneity = 0.60), for tremor-dominant (p-trend < 0.01) than for non-tremor-dominant PD (p-trend = 0.24). CONCLUSIONS: This study helps to better characterize different aspects of pesticide exposure associated with PD, and shows a significant association of pesticides with tremor-dominant PD in men, the most typical PD presentation. CITATION: Moisan F, Spinosi J, Delabre L, Gourlet V, Mazurie JL, Bénatru I, Goldberg M, Weisskopf MG, Imbernon E, Tzourio C, Elbaz A. 2015. Association of Parkinson's disease and its subtypes with agricultural pesticide exposures in men: a case-control study in France. Environ Health Perspect 123:1123-1129; http://dx.doi.org/10.1289/ehp.1307970. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/25815770/Association_of_Parkinson's_Disease_and_Its_Subtypes_with_Agricultural_Pesticide_Exposures_in_Men:_A_Case_Control_Study_in_France_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/ehp.1307970?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -