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Identification and bioactivity of compounds from the fungus Penicillium sp. CYE-87 isolated from a marine tunicate.
Mar Drugs. 2015 Mar 25; 13(4):1698-709.MD

Abstract

In the course of our continuous interest in identifying bioactive compounds from marine microbes, we have investigated a tunicate-derived fungus, Penicillium sp. CYE-87. A new compound with the 1,4-diazepane skeleton, terretrione D (2), together with the known compounds, methyl-2-([2-(1H-indol-3-yl)ethyl]carbamoyl)acetate (1), tryptamine (3), indole-3-carbaldehyde (4), 3,6-diisobutylpyrazin-2(1H)-one (5) and terretrione C (6), were isolated from Penicillium sp. CYE-87. The structures of the isolated compounds were established by spectral analysis, including 1D (1H, 13C) and 2D (COSY, multiplicity edited-HSQC and HMBC) NMR and HRESIMS, as well as comparison of their NMR data with those in the literature. The compounds were evaluated for their antimigratory activity against the human breast cancer cell line (MDA-MB-231) and their antiproliferation activity against HeLa cells. Compounds 2 and 6 showed significant antimigratory activity against MDA-MB-231, as well as antifungal activity against C. albicans.

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Authors+Show Affiliations

Shaala LA
Natural Products Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia. lshalla@kau.edu.sa. Suez Canal University Hospital, Suez Canal University, Ismailia 51522, Egypt. lshalla@kau.edu.sa.
Youssef DT
Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. dyoussef@kau.edu.sa.

MeSH

AlkaloidsAnimalsAntibiotics, AntineoplasticAntifungal AgentsAquatic OrganismsAzepinesCandida albicansCell Line, TumorCell MovementCell ProliferationCulture Media, ConditionedDrug DiscoveryEgyptHumansMolecular StructureMyceliumNeoplasmsPenicilliumSeawaterStereoisomerismTropoloneUrochordata

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25815893

Citation

Shaala, Lamiaa A., and Diaa T A. Youssef. "Identification and Bioactivity of Compounds From the Fungus Penicillium Sp. CYE-87 Isolated From a Marine Tunicate." Marine Drugs, vol. 13, no. 4, 2015, pp. 1698-709.
Shaala LA, Youssef DT. Identification and bioactivity of compounds from the fungus Penicillium sp. CYE-87 isolated from a marine tunicate. Mar Drugs. 2015;13(4):1698-709.
Shaala, L. A., & Youssef, D. T. (2015). Identification and bioactivity of compounds from the fungus Penicillium sp. CYE-87 isolated from a marine tunicate. Marine Drugs, 13(4), 1698-709. https://doi.org/10.3390/md13041698
Shaala LA, Youssef DT. Identification and Bioactivity of Compounds From the Fungus Penicillium Sp. CYE-87 Isolated From a Marine Tunicate. Mar Drugs. 2015 Mar 25;13(4):1698-709. PubMed PMID: 25815893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification and bioactivity of compounds from the fungus Penicillium sp. CYE-87 isolated from a marine tunicate. AU - Shaala,Lamiaa A, AU - Youssef,Diaa T A, Y1 - 2015/03/25/ PY - 2014/12/26/received PY - 2015/03/13/revised PY - 2015/03/18/accepted PY - 2015/3/28/entrez PY - 2015/3/31/pubmed PY - 2015/12/31/medline SP - 1698 EP - 709 JF - Marine drugs JO - Mar Drugs VL - 13 IS - 4 N2 - In the course of our continuous interest in identifying bioactive compounds from marine microbes, we have investigated a tunicate-derived fungus, Penicillium sp. CYE-87. A new compound with the 1,4-diazepane skeleton, terretrione D (2), together with the known compounds, methyl-2-([2-(1H-indol-3-yl)ethyl]carbamoyl)acetate (1), tryptamine (3), indole-3-carbaldehyde (4), 3,6-diisobutylpyrazin-2(1H)-one (5) and terretrione C (6), were isolated from Penicillium sp. CYE-87. The structures of the isolated compounds were established by spectral analysis, including 1D (1H, 13C) and 2D (COSY, multiplicity edited-HSQC and HMBC) NMR and HRESIMS, as well as comparison of their NMR data with those in the literature. The compounds were evaluated for their antimigratory activity against the human breast cancer cell line (MDA-MB-231) and their antiproliferation activity against HeLa cells. Compounds 2 and 6 showed significant antimigratory activity against MDA-MB-231, as well as antifungal activity against C. albicans. SN - 1660-3397 UR - https://www.unboundmedicine.com/medline/citation/25815893/Identification_and_bioactivity_of_compounds_from_the_fungus_Penicillium_sp__CYE_87_isolated_from_a_marine_tunicate_ DB - PRIME DP - Unbound Medicine ER -