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Tracheobronchial brush cytology and bronchoalveolar lavage in dogs and cats with chronic cough: 45 cases (2012-2014).
J Vet Intern Med. 2015 Mar-Apr; 29(2):526-32.JV

Abstract

BACKGROUND

Animals with chronic cough can have normal bronchoalveolar lavage fluid cytology when small airway disease is absent. Cytology of a tracheobronchial brushing can detect inflammation in larger airways; however, evaluation of this technique has been limited in veterinary medicine.

OBJECTIVE

To compare airway brush cytology to bronchoalveolar lavage fluid analysis in dogs and cats with chronic cough.

ANIMALS

Forty dogs and five cats undergoing bronchoscopic investigation of chronic cough.

METHODS

Prospective study. Bronchoscopy and bronchoalveolar lavage were performed followed by tracheobronchial brushing of central airways. Results of cytologic assessment of BAL fluid and brush cytology were compared for the presence or absence of inflammation and concordance of inflammatory cell type.

RESULTS

Brush cytology detected central airway inflammation in 34 of 40 (85%) dogs with inflammatory BAL fluid. However, the type of inflammation reported differed in 23 of 34 dogs. In five cats with inflammation in BAL fluid, brush cytology detected inflammation in four; the type of inflammation was discordant in all cats.

CONCLUSIONS AND CLINICAL RELEVANCE

Brush cytology has good agreement with BAL regarding the presence of inflammation, although the type of inflammation detected with the different sampling techniques commonly varies. Brush cytology can provide supplementary information to BAL, and additional studies will provide further information on the role of tracheobronchial brush cytology in the diagnosis and management of respiratory conditions.

Authors+Show Affiliations

William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25818208

Citation

Zhu, B Y., et al. "Tracheobronchial Brush Cytology and Bronchoalveolar Lavage in Dogs and Cats With Chronic Cough: 45 Cases (2012-2014)." Journal of Veterinary Internal Medicine, vol. 29, no. 2, 2015, pp. 526-32.
Zhu BY, Johnson LR, Vernau W. Tracheobronchial brush cytology and bronchoalveolar lavage in dogs and cats with chronic cough: 45 cases (2012-2014). J Vet Intern Med. 2015;29(2):526-32.
Zhu, B. Y., Johnson, L. R., & Vernau, W. (2015). Tracheobronchial brush cytology and bronchoalveolar lavage in dogs and cats with chronic cough: 45 cases (2012-2014). Journal of Veterinary Internal Medicine, 29(2), 526-32. https://doi.org/10.1111/jvim.12566
Zhu BY, Johnson LR, Vernau W. Tracheobronchial Brush Cytology and Bronchoalveolar Lavage in Dogs and Cats With Chronic Cough: 45 Cases (2012-2014). J Vet Intern Med. 2015 Mar-Apr;29(2):526-32. PubMed PMID: 25818208.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tracheobronchial brush cytology and bronchoalveolar lavage in dogs and cats with chronic cough: 45 cases (2012-2014). AU - Zhu,B Y, AU - Johnson,L R, AU - Vernau,W, PY - 2014/08/23/received PY - 2014/12/18/revised PY - 2015/01/29/accepted PY - 2015/3/31/entrez PY - 2015/3/31/pubmed PY - 2015/12/17/medline KW - Bronchi KW - Cat KW - Dog KW - Endoscopy KW - Respiratory tract SP - 526 EP - 32 JF - Journal of veterinary internal medicine JO - J Vet Intern Med VL - 29 IS - 2 N2 - BACKGROUND: Animals with chronic cough can have normal bronchoalveolar lavage fluid cytology when small airway disease is absent. Cytology of a tracheobronchial brushing can detect inflammation in larger airways; however, evaluation of this technique has been limited in veterinary medicine. OBJECTIVE: To compare airway brush cytology to bronchoalveolar lavage fluid analysis in dogs and cats with chronic cough. ANIMALS: Forty dogs and five cats undergoing bronchoscopic investigation of chronic cough. METHODS: Prospective study. Bronchoscopy and bronchoalveolar lavage were performed followed by tracheobronchial brushing of central airways. Results of cytologic assessment of BAL fluid and brush cytology were compared for the presence or absence of inflammation and concordance of inflammatory cell type. RESULTS: Brush cytology detected central airway inflammation in 34 of 40 (85%) dogs with inflammatory BAL fluid. However, the type of inflammation reported differed in 23 of 34 dogs. In five cats with inflammation in BAL fluid, brush cytology detected inflammation in four; the type of inflammation was discordant in all cats. CONCLUSIONS AND CLINICAL RELEVANCE: Brush cytology has good agreement with BAL regarding the presence of inflammation, although the type of inflammation detected with the different sampling techniques commonly varies. Brush cytology can provide supplementary information to BAL, and additional studies will provide further information on the role of tracheobronchial brush cytology in the diagnosis and management of respiratory conditions. SN - 1939-1676 UR - https://www.unboundmedicine.com/medline/citation/25818208/Tracheobronchial_brush_cytology_and_bronchoalveolar_lavage_in_dogs_and_cats_with_chronic_cough:_45_cases__2012_2014__ L2 - https://doi.org/10.1111/jvim.12566 DB - PRIME DP - Unbound Medicine ER -