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Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men.
Atherosclerosis. 2015 May; 240(1):272-7.A

Abstract

OBJECTIVE

We investigated the association of various lipoprotein traits, apolipoproteins and their ratios with the deterioration of glycemia, incident type 2 diabetes, insulin resistance and insulin secretion in a large population-based Metabolic Syndrome Men (METSIM) Study.

RESEARCH DESIGN AND METHODS

The METSIM Study includes 10,197 Finnish men, aged 45-73 years, and examined in 2005-2010. From 6607 non-diabetic participants without statin treatment at baseline, 386 developed incident type 2 diabetes during a 5.9-year follow-up. A total of 3330 non-diabetic participants without statin treatment had both baseline and follow-up visit data, and were included in statistical analyses of the worsening of glycemia.

RESULTS

Compared to single lipid and lipoprotein measurements, lipoprotein and apolipoprotein ratios were better predictors of the glucose area under the curve and incident type 2 diabetes after adjustment for confounding factors. The apolipoprotein B/LDL cholesterol ratio was the strongest predictor of the worsening of glycemia, whereas the apolipoprotein A1/HDL cholesterol ratio was the strongest predictor of incident type 2 diabetes. The associations of lipoprotein traits, apolipoproteins and their ratios with insulin sensitivity were stronger than those with insulin secretion.

CONCLUSIONS

The apolipoprotein B/LDL cholesterol and apolipoprotein A1/HDL cholesterol ratios were the strongest predictors of the worsening of glycemia and incident type 2 diabetes, respectively.

Authors+Show Affiliations

Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.Internal Medicine, Kuopio University Hospital, Kuopio, Finland.Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland.Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland; Internal Medicine, Kuopio University Hospital, Kuopio, Finland.Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland; Oulu University Hospital, Oulu, Finland; Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland; Internal Medicine, Kuopio University Hospital, Kuopio, Finland.Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland. Electronic address: alena.stancakova@uef.fi.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25818853

Citation

Fizelova, Maria, et al. "Associations of Multiple Lipoprotein and Apolipoprotein Measures With Worsening of Glycemia and Incident Type 2 Diabetes in 6607 Non-diabetic Finnish Men." Atherosclerosis, vol. 240, no. 1, 2015, pp. 272-7.
Fizelova M, Miilunpohja M, Kangas AJ, et al. Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men. Atherosclerosis. 2015;240(1):272-7.
Fizelova, M., Miilunpohja, M., Kangas, A. J., Soininen, P., Kuusisto, J., Ala-Korpela, M., Laakso, M., & Stančáková, A. (2015). Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men. Atherosclerosis, 240(1), 272-7. https://doi.org/10.1016/j.atherosclerosis.2015.03.034
Fizelova M, et al. Associations of Multiple Lipoprotein and Apolipoprotein Measures With Worsening of Glycemia and Incident Type 2 Diabetes in 6607 Non-diabetic Finnish Men. Atherosclerosis. 2015;240(1):272-7. PubMed PMID: 25818853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men. AU - Fizelova,Maria, AU - Miilunpohja,Manna, AU - Kangas,Antti J, AU - Soininen,Pasi, AU - Kuusisto,Johanna, AU - Ala-Korpela,Mika, AU - Laakso,Markku, AU - Stančáková,Alena, Y1 - 2015/03/23/ PY - 2015/02/18/received PY - 2015/03/16/revised PY - 2015/03/20/accepted PY - 2015/3/31/entrez PY - 2015/3/31/pubmed PY - 2016/1/5/medline KW - Apolipoproteins KW - Atherogenic indices KW - Hyperglycemia KW - Insulin resistance KW - Insulin secretion KW - Lipoproteins KW - Type 2 diabetes SP - 272 EP - 7 JF - Atherosclerosis JO - Atherosclerosis VL - 240 IS - 1 N2 - OBJECTIVE: We investigated the association of various lipoprotein traits, apolipoproteins and their ratios with the deterioration of glycemia, incident type 2 diabetes, insulin resistance and insulin secretion in a large population-based Metabolic Syndrome Men (METSIM) Study. RESEARCH DESIGN AND METHODS: The METSIM Study includes 10,197 Finnish men, aged 45-73 years, and examined in 2005-2010. From 6607 non-diabetic participants without statin treatment at baseline, 386 developed incident type 2 diabetes during a 5.9-year follow-up. A total of 3330 non-diabetic participants without statin treatment had both baseline and follow-up visit data, and were included in statistical analyses of the worsening of glycemia. RESULTS: Compared to single lipid and lipoprotein measurements, lipoprotein and apolipoprotein ratios were better predictors of the glucose area under the curve and incident type 2 diabetes after adjustment for confounding factors. The apolipoprotein B/LDL cholesterol ratio was the strongest predictor of the worsening of glycemia, whereas the apolipoprotein A1/HDL cholesterol ratio was the strongest predictor of incident type 2 diabetes. The associations of lipoprotein traits, apolipoproteins and their ratios with insulin sensitivity were stronger than those with insulin secretion. CONCLUSIONS: The apolipoprotein B/LDL cholesterol and apolipoprotein A1/HDL cholesterol ratios were the strongest predictors of the worsening of glycemia and incident type 2 diabetes, respectively. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/25818853/Associations_of_multiple_lipoprotein_and_apolipoprotein_measures_with_worsening_of_glycemia_and_incident_type_2_diabetes_in_6607_non_diabetic_Finnish_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(15)00194-X DB - PRIME DP - Unbound Medicine ER -