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Psychopathological manifestations of joint hypermobility and joint hypermobility syndrome/ Ehlers-Danlos syndrome, hypermobility type: The link between connective tissue and psychological distress revised.
Am J Med Genet C Semin Med Genet 2015; 169C(1):97-106AJ

Abstract

Psychological distress is a known feature of generalized joint hypermobility (gJHM), as well as of its most common syndromic presentation, namely Ehlers-Danlos syndrome, hypermobility type (a.k.a. joint hypermobility syndrome - JHS/EDS-HT), and significantly contributes to the quality of life of affected individuals. Most published articles dealt with the link between gJHM (or JHS/EDS-HT) and anxiety-related conditions, and a novel generation of studies is emerging aimed at investigating the psychopathologic background of such an association. In this paper, literature review was carried out with a semi-systematic approach spanning the entire spectrum of psychopathological findings in gJHM and JHS/EDS-HT. Interestingly, in addition to the confirmation of a tight link between anxiety and gJHM, preliminary connections with depression, attention deficit (and hyperactivity) disorder, autism spectrum disorders, and obsessive-compulsive personality disorder were also found. Few papers investigated the relationship with schizophrenia with contrasting results. The mind-body connections hypothesized on the basis of available data were discussed with focus on somatotype, presumed psychopathology, and involvement of the extracellular matrix in the central nervous system. The hypothesis of positive Beighton score and alteration of interoceptive/proprioceptive/body awareness as possible endophenotypes in families with symptomatic gJHM or JHS/EDS-HT is also suggested. Concluding remarks addressed the implications of the psychopathological features of gJHM and JHS/EDS-HT in clinical practice.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25821094

Citation

Sinibaldi, Lorenzo, et al. "Psychopathological Manifestations of Joint Hypermobility and Joint Hypermobility Syndrome/ Ehlers-Danlos Syndrome, Hypermobility Type: the Link Between Connective Tissue and Psychological Distress Revised." American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, vol. 169C, no. 1, 2015, pp. 97-106.
Sinibaldi L, Ursini G, Castori M. Psychopathological manifestations of joint hypermobility and joint hypermobility syndrome/ Ehlers-Danlos syndrome, hypermobility type: The link between connective tissue and psychological distress revised. Am J Med Genet C Semin Med Genet. 2015;169C(1):97-106.
Sinibaldi, L., Ursini, G., & Castori, M. (2015). Psychopathological manifestations of joint hypermobility and joint hypermobility syndrome/ Ehlers-Danlos syndrome, hypermobility type: The link between connective tissue and psychological distress revised. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 169C(1), pp. 97-106. doi:10.1002/ajmg.c.31430.
Sinibaldi L, Ursini G, Castori M. Psychopathological Manifestations of Joint Hypermobility and Joint Hypermobility Syndrome/ Ehlers-Danlos Syndrome, Hypermobility Type: the Link Between Connective Tissue and Psychological Distress Revised. Am J Med Genet C Semin Med Genet. 2015;169C(1):97-106. PubMed PMID: 25821094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychopathological manifestations of joint hypermobility and joint hypermobility syndrome/ Ehlers-Danlos syndrome, hypermobility type: The link between connective tissue and psychological distress revised. AU - Sinibaldi,Lorenzo, AU - Ursini,Gianluca, AU - Castori,Marco, PY - 2015/3/31/entrez PY - 2015/3/31/pubmed PY - 2015/12/17/medline KW - Ehlers-Danlos syndrome KW - anxiety KW - joint hypermobility KW - psychopathology KW - somatotype SP - 97 EP - 106 JF - American journal of medical genetics. Part C, Seminars in medical genetics JO - Am J Med Genet C Semin Med Genet VL - 169C IS - 1 N2 - Psychological distress is a known feature of generalized joint hypermobility (gJHM), as well as of its most common syndromic presentation, namely Ehlers-Danlos syndrome, hypermobility type (a.k.a. joint hypermobility syndrome - JHS/EDS-HT), and significantly contributes to the quality of life of affected individuals. Most published articles dealt with the link between gJHM (or JHS/EDS-HT) and anxiety-related conditions, and a novel generation of studies is emerging aimed at investigating the psychopathologic background of such an association. In this paper, literature review was carried out with a semi-systematic approach spanning the entire spectrum of psychopathological findings in gJHM and JHS/EDS-HT. Interestingly, in addition to the confirmation of a tight link between anxiety and gJHM, preliminary connections with depression, attention deficit (and hyperactivity) disorder, autism spectrum disorders, and obsessive-compulsive personality disorder were also found. Few papers investigated the relationship with schizophrenia with contrasting results. The mind-body connections hypothesized on the basis of available data were discussed with focus on somatotype, presumed psychopathology, and involvement of the extracellular matrix in the central nervous system. The hypothesis of positive Beighton score and alteration of interoceptive/proprioceptive/body awareness as possible endophenotypes in families with symptomatic gJHM or JHS/EDS-HT is also suggested. Concluding remarks addressed the implications of the psychopathological features of gJHM and JHS/EDS-HT in clinical practice. SN - 1552-4876 UR - https://www.unboundmedicine.com/medline/citation/25821094/Psychopathological_manifestations_of_joint_hypermobility_and_joint_hypermobility_syndrome/_Ehlers_Danlos_syndrome_hypermobility_type:_The_link_between_connective_tissue_and_psychological_distress_revised_ L2 - https://doi.org/10.1002/ajmg.c.31430 DB - PRIME DP - Unbound Medicine ER -