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Effect of Lactobacillus plantarum NCU116 on loperamide-induced constipation in mice.
Int J Food Sci Nutr. 2015; 66(5):533-8.IJ

Abstract

Lactobacillus plantarum, as a probiotic, has many functional properties in human intestinal tract. This study examined the effects of L. plantarum NCU116 on loperamide-induced constipation in a mouse model. Loperamide (5 mg kg(-1)) was injected subcutaneously to induce constipation. Animals were divided to five groups: normal group, constipation group, constipation plus three doses of L. plantarum NCU116 groups (NCU116-L, 10(7) CFU/mL; NCU116-M, 10(8) CFU/mL; NCU116-H, 10(9) CFU/mL; respectively). Mice were treated with the probiotic for 15 d to assess the anti-constipation effects. Fecal parameters, intestinal transit ratio and the production of fecal short chain fatty acids, histological of colon and immunohistochemical in colonic interstitial cells of Cajal (ICC) by c-kit were all improved in L. plantarum NCU116-treated mice as compared to the constipation group. These results demonstrate that L. plantarum NCU116 enhanced gastrointestinal transit and alleviated in mice with loperamide-induced constipation.

Authors+Show Affiliations

State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang , China and.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25822005

Citation

Li, Chuan, et al. "Effect of Lactobacillus Plantarum NCU116 On Loperamide-induced Constipation in Mice." International Journal of Food Sciences and Nutrition, vol. 66, no. 5, 2015, pp. 533-8.
Li C, Nie SP, Zhu KX, et al. Effect of Lactobacillus plantarum NCU116 on loperamide-induced constipation in mice. Int J Food Sci Nutr. 2015;66(5):533-8.
Li, C., Nie, S. P., Zhu, K. X., Xiong, T., Li, C., Gong, J., & Xie, M. Y. (2015). Effect of Lactobacillus plantarum NCU116 on loperamide-induced constipation in mice. International Journal of Food Sciences and Nutrition, 66(5), 533-8. https://doi.org/10.3109/09637486.2015.1024204
Li C, et al. Effect of Lactobacillus Plantarum NCU116 On Loperamide-induced Constipation in Mice. Int J Food Sci Nutr. 2015;66(5):533-8. PubMed PMID: 25822005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Lactobacillus plantarum NCU116 on loperamide-induced constipation in mice. AU - Li,Chuan, AU - Nie,Shao-Ping, AU - Zhu,Ke-Xue, AU - Xiong,Tao, AU - Li,Chang, AU - Gong,Joshua, AU - Xie,Ming-Yong, Y1 - 2015/03/30/ PY - 2015/3/31/entrez PY - 2015/3/31/pubmed PY - 2016/5/3/medline KW - Constipation KW - Lactobacillus plantarum NCU116 KW - histological findings KW - loperamide KW - short chain fatty acids SP - 533 EP - 8 JF - International journal of food sciences and nutrition JO - Int J Food Sci Nutr VL - 66 IS - 5 N2 - Lactobacillus plantarum, as a probiotic, has many functional properties in human intestinal tract. This study examined the effects of L. plantarum NCU116 on loperamide-induced constipation in a mouse model. Loperamide (5 mg kg(-1)) was injected subcutaneously to induce constipation. Animals were divided to five groups: normal group, constipation group, constipation plus three doses of L. plantarum NCU116 groups (NCU116-L, 10(7) CFU/mL; NCU116-M, 10(8) CFU/mL; NCU116-H, 10(9) CFU/mL; respectively). Mice were treated with the probiotic for 15 d to assess the anti-constipation effects. Fecal parameters, intestinal transit ratio and the production of fecal short chain fatty acids, histological of colon and immunohistochemical in colonic interstitial cells of Cajal (ICC) by c-kit were all improved in L. plantarum NCU116-treated mice as compared to the constipation group. These results demonstrate that L. plantarum NCU116 enhanced gastrointestinal transit and alleviated in mice with loperamide-induced constipation. SN - 1465-3478 UR - https://www.unboundmedicine.com/medline/citation/25822005/Effect_of_Lactobacillus_plantarum_NCU116_on_loperamide_induced_constipation_in_mice_ DB - PRIME DP - Unbound Medicine ER -