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Altered attention networks in benign childhood epilepsy with centrotemporal spikes (BECTS): A resting-state fMRI study.
Epilepsy Behav. 2015 Apr; 45:234-41.EB

Abstract

It is noteworthy that some children with benign childhood epilepsy with centrotemporal spikes (BECTS) show attention problems despite their favorable seizure outcome. Resting-state functional magnetic resonance imaging (fMRI) is a method widely used to detect brain network alterations in neuropsychiatric diseases. We used resting-state functional magnetic resonance imaging (fMRI) to investigate specific brain networks related to attention deficit in children with BECTS. Resting-state fMRI was performed in patients with BECTS with ADHD (n=15) and those with BECTS without ADHD (n=15) and in healthy controls (n=15). Unbiased seed-based whole-brain functional connectivity analysis was used to study the connectivity pattern of three resting-state networks, including the ventral attention network (VAN) and the dorsal attention network (DAN) and the default mode network (DMN). Patients with BECTS with ADHD displayed decreased functional connectivity in the DAN compared with other two groups, while patients with BECTS without ADHD showed increased functional connectivity in the DAN. Moreover, we found increased functional connectivity in the VAN and in the DMN in patients with BECTS with or without ADHD when comparing with controls. These results showed that the newly-diagnosed children with BECTS displayed brain activity alterations in the ventral and dorsal attention networks. The difference in the extent of impairment in the dorsal attention network of patients with BECTS with ADHD and patients with BECTS without ADHD may lead to improved understanding of the underlying neuropathophysiology and treatment of BECTS with ADHD and BECTS without ADHD.

Authors+Show Affiliations

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: zhoudong66@yahoo.de.Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: qiyonggong@hmrrc.org.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25825370

Citation

Xiao, Fenglai, et al. "Altered Attention Networks in Benign Childhood Epilepsy With Centrotemporal Spikes (BECTS): a Resting-state fMRI Study." Epilepsy & Behavior : E&B, vol. 45, 2015, pp. 234-41.
Xiao F, Li L, An D, et al. Altered attention networks in benign childhood epilepsy with centrotemporal spikes (BECTS): A resting-state fMRI study. Epilepsy Behav. 2015;45:234-41.
Xiao, F., Li, L., An, D., Lei, D., Tang, Y., Yang, T., Ren, J., Chen, S., Huang, X., Gong, Q., & Zhou, D. (2015). Altered attention networks in benign childhood epilepsy with centrotemporal spikes (BECTS): A resting-state fMRI study. Epilepsy & Behavior : E&B, 45, 234-41. https://doi.org/10.1016/j.yebeh.2015.01.016
Xiao F, et al. Altered Attention Networks in Benign Childhood Epilepsy With Centrotemporal Spikes (BECTS): a Resting-state fMRI Study. Epilepsy Behav. 2015;45:234-41. PubMed PMID: 25825370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered attention networks in benign childhood epilepsy with centrotemporal spikes (BECTS): A resting-state fMRI study. AU - Xiao,Fenglai, AU - Li,Lei, AU - An,Dongmei, AU - Lei,Du, AU - Tang,Yingying, AU - Yang,Tianhua, AU - Ren,Jiechuan, AU - Chen,Sihan, AU - Huang,Xiaoqi, AU - Gong,Qiyong, AU - Zhou,Dong, Y1 - 2015/03/29/ PY - 2014/12/02/received PY - 2015/01/03/revised PY - 2015/01/12/accepted PY - 2015/4/1/entrez PY - 2015/4/1/pubmed PY - 2015/12/15/medline KW - Attention deficit and hyperactivity disorder KW - Benign childhood epilepsy with centrotemporal spikes KW - Functional connectivity KW - fMRI SP - 234 EP - 41 JF - Epilepsy & behavior : E&B JO - Epilepsy Behav VL - 45 N2 - It is noteworthy that some children with benign childhood epilepsy with centrotemporal spikes (BECTS) show attention problems despite their favorable seizure outcome. Resting-state functional magnetic resonance imaging (fMRI) is a method widely used to detect brain network alterations in neuropsychiatric diseases. We used resting-state functional magnetic resonance imaging (fMRI) to investigate specific brain networks related to attention deficit in children with BECTS. Resting-state fMRI was performed in patients with BECTS with ADHD (n=15) and those with BECTS without ADHD (n=15) and in healthy controls (n=15). Unbiased seed-based whole-brain functional connectivity analysis was used to study the connectivity pattern of three resting-state networks, including the ventral attention network (VAN) and the dorsal attention network (DAN) and the default mode network (DMN). Patients with BECTS with ADHD displayed decreased functional connectivity in the DAN compared with other two groups, while patients with BECTS without ADHD showed increased functional connectivity in the DAN. Moreover, we found increased functional connectivity in the VAN and in the DMN in patients with BECTS with or without ADHD when comparing with controls. These results showed that the newly-diagnosed children with BECTS displayed brain activity alterations in the ventral and dorsal attention networks. The difference in the extent of impairment in the dorsal attention network of patients with BECTS with ADHD and patients with BECTS without ADHD may lead to improved understanding of the underlying neuropathophysiology and treatment of BECTS with ADHD and BECTS without ADHD. SN - 1525-5069 UR - https://www.unboundmedicine.com/medline/citation/25825370/Altered_attention_networks_in_benign_childhood_epilepsy_with_centrotemporal_spikes__BECTS_:_A_resting_state_fMRI_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1525-5050(15)00023-2 DB - PRIME DP - Unbound Medicine ER -